Effects of 2-chlorodeoxyadenosine and gold sodium thiomalate on human bcl-2 gene expression

Immunopharmacology and Immunotoxicology

Volumn 20, Issue 1, 1998, Pages 63-77

  Sfikakis, P P ^a,d   Dimopoulos, M A ^b   Souliotis, V L ^c   Charalambopoulos, D ^a   Mavrikakis, M ^b   Panayiotidis, P ^a  

^a LAIKO GENERAL HOSPITAL   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c INSTITUTE OF BIOLOGY   (Greece)

^d NONE   (Greece)

Author keywords

2 chlorodeoxyadenosine; Apoptosis; Bcl 2; Gold salts; Interleukin 2; Lymphocytes

Indexed keywords

AUROTHIOMALATE; CLADRIBINE;

ARTICLE; AUTOIMMUNE DISEASE; CANCER; CELL DEATH; CHEMICAL CARCINOGENESIS; DRUG DNA INTERACTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; PATHOGENESIS; PRIORITY JOURNAL; SUPPRESSOR GENE;

EID: 0031919092     PISSN: 08923973     EISSN: None     Source Type: Journal    
DOI: 10.3109/08923979809034809     Document Type: Article

References (40)

1. Aringer, M., Wintersberger, W., Steiner, C. W., Kiener, H., Presteri, E., Jaeger, U., Smolen, J. S., Graninger, W. B. High levels of bcl-2 protein in circulating T lymphocytes, but not B lymphocytes, of patients with systemic lupus erythematosus. Arthritis Rheum. 1994 ; 37: 1423.
2. 1) lymphocytes. II. Glucocorticoid and antiTac-induced inhibition of human T lymphocyte proliferation. J. Immunol ., 1984 ; 132: 261.
3. Carrera, C. J., Terai, C., Curd, J. G., Piro, L. D., Beutler, E., Carson, D. A. Potent toxicity of 2-chloro-deoxyadenosine toward human monocytes in vitro and in vivo. J. Clin. Invest., 1990; 86: 1480.
4. Carrera, C. J., Weisman, M., Amox, D., Clason, M., Carson, D. A. Oral 2-chlorodeoxyadenosine treatment for rheumatoid arthritis. Arthritis Rheum., 1994 ; 37: No 9, (suppl.) S421.
5. Carson, D. A., Wasson, D. B., Esparza, L. M., Carrera, C.J., Kipps, T.J., Cottam H., B. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2-arabino-fluoro-2-deoxyadenosine. Proc. Natl. Acad. Sci., 1992 ; 89: 2970.
6. Dimopoulos, M. A. Kantarjian, H., Estey, E., O'Brien, S., DelaSalle, K., Keating, M. J., Freirich, E. J., Alexanian, R. Treatment of Waldenstrom's macroglobulinemia with 2-chlorodeoxyadenosine. Ann. Intern. Med. 1993 ; 118: 195.
7. Eibschutz, B., Baird, S. M., Weisman, M. H., Amox, D. G., Spellman, M., Piacquadio, D., Carrera, C.J., Carson, D. A. Oral 2-chlorodeoxyadenosine in psoriatic arthritis. Arthritis Rheum. 1995 ; 38: 1604.
8. Firestein, G. S., Yeo, M., Zvaifler, N. J. Apoptosis in rheumatoid arthritis synovium. J. Clin. Invest., 1995 ; 96 : 1631
9. Gorski, A., Grieb, P., Makula, J., Stepien-Sopniewska, B., Mrowiec, T. & Nowaczyk, M. 2-chloro-2-deoxyadenosine: a novel immunosuppressive agent. Transplantation, 1993a ; 56 : 1253.
10. Gorski, A., Grieb, P., Korczak-Kowalska, G., Wierzbicki, P., Stepien-Sopniewska, B., Mrowiec, T. Cladribine (2-chloro-deoxyadenosine, CDA): an inhibitor of human B and T cell activation in vitro. Immunopharmacology, 1993b ; 26: 197.
11. Gottlieb, N. L. Comparative pharmacokinetics of parenteral and oral gold compounds. J. Rheumatol., 1982 ; (suppl. 9) : 99.
12. Hashimoto, K., Whitehurst, C. E., Matsubara, T., Hirohata, K., Lipsky, P. E. Immunomodulatory effects of therapeutic gold compounds: gold sodium thiomalate inhibits the activity of T cell protein kinase C. J. Clin. Invest., 1992; 89: 1839.
13. Hawkins, C. J., Vaux, D. L. Analysis of the role of bcl-2 in apoptosis. Immunol. Reviews, 1994; 142 : 127.
14. Hearth-Holmes, M., Holcombe, R. F., Elder, C., Wolf, R.E. 2-chlorodeoxyadenosine (2-CdA) in patients wth systemic lupus erythematosus and other autoimmune diseases. Arthritis Rheum., 1995 ; 38 : No 9 (suppl.) S304.
15. Huang, M. C., Ashmun, R. A., Avery, T. L., Kuehl, M., Blakley, R. L. Effects and cytotoxicity of 2-chloro-2′-deoxyadenosine and 2-bromo-2′-deoxyadenosine on cell growth, clonogenicity, DNA synthesis, and cell cycle kinetics. Cancer Res., 1986; 46: 2362.
16. Lipsky, P. E. Mechanisms of action of slow acting drugs in rheumatoid arthritis. Clin. Exp. Rheumatol., 1989; 3: 177.
17. Massarotti, E. M., Liu, N. Y., Mier, J., Atkins, M. B. Chronic inflammatory arthritis after treatment with high-dose interleukin-2 for malignancy. Am. J. Med., 1992; 92 : 693.
18. Moreland, L. W., Sewell, K. L., Trentham, D. E., Bucy, R. P., Sullivan, W. F., Schrohenloher, R. E., Shmerling, R. H., Parker, K. C., Swartz, W. G., Woodworth, G., Koopman, W. J. Interleukin-2 diphtheria fusion protein (DAB 486IL-2) in refractory rheumatoid arthritis. Arthritis Rheum., 1995; 38: 1177.
19. Mountz, J. D, Wy, J., Cheng, J., Zhou, T. Autoimmune disease. A problem of defective apoptosis. Arthritis Rheum., 1991 ; 37: 1415.
20. Muller-Laduer, U., Kriegsman, J., Gay, R. F., Mountz, J. D., Nishioka K., Talal N., Gay, S. Upregulation of bcl-2 mRNA in synovium of patients with Rheumatoid Arthritis. Arthritis Rheum., 1994 ; 37: No 9 (suppl) S163.
21. Nakayama, K.-I., Nakayama, K., Negishi, I., Kuida, K., Shinkai, Y., Louie, M. C., Fields, L.E., Lucas, P. J., Stewart, V., Alt, F. W., Loh, D.Y. Disappearance of the lymphoid system in bcl-2 homozygous mutant himeric mice. Science, 1993; 261: 1584.
22. Panayi, G. S., Lanchbury, J.S, Kingsley, G.H. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis (editorial). Arthritis Rheum., 1992; 35:729.
23. Panayiotidis, P., Kanagasabai, G., Jabbar, S. A. B., Hoffbrand, A.V. Interleukin-4 inhibits apoptotic cell death and loss of the bcl-2 protein in B-chronic lymphocytic leukemia cells in vitro. Br. J. Haematol., 1993; 85: 439.
24. Piro, L. D., Carrera, C. J., Beutler, E., Carson, D. A. Lasting remission in hairy cell leukemia-like induced by a single infusion of 2-chlorodeoxyadenosine. N Engl. J. Med., 1990; 322 : 1117.
25. Reed, J. C., Tsujimoto, Y., Alpers, J.D., Croce, C. M., Nowell, P. Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation. Science, 1987; 236, 1295.
26. Reed, J. C. Bcl-2 family proteins and mechanisms of chemoresistance in lymphomas and leukemias. Adv Leukemia Lymphoma 1995; 5, No3: 3.
27. Robertson, L. E., Shubb, S., Meyen, R.E., Story, M., Ford, R., Hittelman, W. N., Plunkett, W. Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2′deoxyadenosine and 9-β-Darabinosyl-2-fluoroandenine. Blood, 1992; 81: 143.
28. Santana, V. M., Hurwitz, C.A., Blakley, R. L., Crom, W.R., Luo, X., Roberts, W.M., Ribeiro, R., Mahmoud, H., Krance, R. A. Complete hematologic remissions induced by 2-chlorodeoxyadenosine in children with newly diagnosed acute myeloid leukemia. Blood, 1994; 84: 1237.
29. Sipe, J.C., Romine, J.S., Koziot, J.A. Cladribine in treatment of chronic progressive multiple sclerosis. Lancet , 1994; 344 : 9.
30. Sfikakis, P. P., Souliotis, V., Panayotides, P. P. Suppression of Interleukin-2 and Interleukin-2 receptor biosynthesis by gold compounds in in vitro activated human peripheral blood mononuclear cells. Arthritis Rheum., 1993 ; 36 : 208.
31. Sfikakis, P.P., Panayiotides, P. Suppression of Interleukin-2 and Interleukin-2 receptor biosynthesis by gold compounds in in vitro activated human peripheral blood mononuclear cells. Letter Arthritis Rheum., 1994; 37: 147.
32. Sfikakis, P.P., Souliotis, V., Katsilambros, N., Markakis, K., Vaiopoulos, G., Tsokos, G.C., Panayotidis, P. P. Down-regulation of Interleukin-2 and a-chain Interleukin-2 receptor biosynthesis by cisplatin in human peripheral lymphocytes. Clin Immunol. Immunopathol ., 1996a; 79: 43.
33. Sfikakis, P.P., Souliotis V., Akbar, A. N., Katsilambros N., Hoffbrand, V. A., Panayotides, P. P. Regulation of bcl-2 and fas expression in primary activation of human peripheral lymphocytes is not sensitive to dexamethasone or cyclosporin-A. Human Immunol., 1996b ; 50: 121.
34. Strasser, A., Harris, A. W., Cory, S. BCL-2 transgene inhibits T cell death and perturbs thymic self-sensorchip. Cell, 1991a ; 67: 889.
35. Strasser, A., Whittingham, S., Vaux, D. L., Bath, M. L., Adams, J. M., Cory, S., Harris, A. W. Enforced BCL-2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl. Acad. Sci., 1991b; 88, 8661.
36. Tanghe, A., Delforge, A., Bernier, M., Massy, M., De Leeuw, N., Bron, D., Stryckmans, P. Apoptosis of B-chronic lymphocytic leukemia (CLL) cells in presence of various agents and modulation by Interleukin-4. Blood, 1994; 84 :(Suppl 1 to No 10) 451a.
37. Taniguchi, T., Minami, Y. The IL-2/IL-2 receptor system: a current overview. Cell, 1993; 73: 5.
38. Theofilopoulos, A.N. The basis of autoimmunity: Part II Genetic predisposition, Immunol. Today, 1995; 16 : 150.
39. Ugai, K., Ziff, M., Lipsky, P. E. Gold-induced changes in the morphology and functional capabilities of human monocytes. Arthritis Rheum., 1979; 22 : 1352.
40. Wolf, R. E., Hall, V. C. Inhibition of in vitro proliferation response of cultured T lymphocytes to interleukin-2 by gold sodium thiomalate. Arthritis Rheum., 1988; 31: 176.