Retinoic acid receptor-γ in human epidermis preferentially traps All- trans retinoic acid as its ligand rather than 9-cis retinoic acid

Journal of Investigative Dermatology

Volumn 110, Issue 3, 1998, Pages 297-300

  Fisher, Gary J ^a,b   Datta, Subhash C ^a   Voorhees, John J ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Isomerization; RAR ; RAR ; Retinoids

Indexed keywords

RETINOIC ACID; RETINOIC ACID RECEPTOR; TRANSCRIPTION FACTOR;

ARTICLE; BINDING AFFINITY; CELL GROWTH; CELL MATURATION; EPIDERMIS; EPIDERMIS CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOMERISM; LIGAND BINDING; PRIORITY JOURNAL; SKIN;

EID: 0031918356     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1998.00112.x     Document Type: Article

References (22)

1. Allenby G, Bocquel M-T, Saunders M, et al: Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci USA 90:30-34, 1993
2. Allenby G, Janocha R, Kaziner S, Speck J, Grippo JF, Levin AA: Binding of 9-cis retinoic acid and all-trans, retinoic acid to retinoic acid receptors α. β. and γ J Biol Chem 269: 16689-16695, 1994
3. Chambon P: Function of retinoic acid receptor gamma in the mouse. Cell 73 (4):643 658, 1993
4. Chambon P: A decade of molecular biology of retinoic acid receptors. FASEB J 10 (9):940-954, 1996
5. Duell EA, Kang S, Voorhees JJ: Retinoic acid isomers applied to human skin in vivo each induce a 4-hydroxylase that inactivates only all-trans retinoic acid. J Invest Dermatol 106:316-320, 1996
6. Evans RM: The steroid and thyroid hormone receptor superfamily. Sci 240:889 895, 1988
7. Fisher GJ, Esmann J, Griffiths CEM, et al: Cellular, immunologic and biochemical characterization of topical retinoic acid-treated human skin. J Invest Dermatol 96:699-707, 1991
8. Fisher GJ, Talwar HS, Xiao J-H, et al: Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin. J Biol Chem 269:20629-20635, 1994
9. Green S, Chambon P: Nuclear receptors enhance our understanding of transcription regulation. Trends Genet 4:309-341, 1988
10. Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM, Thaller C: 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 68:397 406, 1992
11. Kang S, Duell EA, Fisher GJ, et al: Application of retinol to human skin in vivo induces epidermal hyperlasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J Invest Dermatol 105:549 556, 1995
12. Kurlandsky SB, Xiao JH, Duell EA, Voorhees JJ, Fisher GJ: Biological activity of all-trans retinol requires metabolic converstion to all-trans retinoic acid is mediated through activation of nuclear retinoid receptors in human keratinocytes. J Biol Chem 269:32821 32827, 1994
13. Lehmann JM, Jong L, Fanjul A, et al: Retinoids selective for retinoid X receptor response pathways. Science 258:1944-1946, 1992
14. Leid M, Kastner P, Chambon P: Multiplicity generates diversity in the retinoic acid signaling pathways. Trends Biochem Sci 17:427-433, 1992
15. Levin AA, Sturzenbecker LJ, Kazmer S, et al: 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR-α. Nature 355:359 361, 1992
16. Mangelsdorf DJ, Umesono K, Evans RM: The retinoid receptors. In: Sporn MB, Robert AB, Goodman DS (eds.) The Retinoids: Biology, Chemistry, and Medicine, 2nd edn. Raven Press, New York, 1994, pp. 319-349
17. Roberts AB, Sporn MB: Cellular biology and biochemistry of the retinoids. In Sporn MB, Roberts AB, Goodman DS (eds). The Retinoids. Academic Press, Orlando, 1984, pp. 209-286
18. Smith SM, Levy NS, Hayes CE: Impaired immunity in vitamin A-deficient mice. J Nutr 117:857 865, 1987
19. Tate BF, Allenby G, Janocha R, et al: Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of retinoid receptor alpha. Mol Cell Biol 14 (4):2323-2330, 1994
20. Thaller C., Eichele G: Identification and spatial distribution of retinoids in the developing chick limb bud. Nature 327:625-628, 1987
21. Thomson JN, Howell JM, Pitt GAJ: Vitamin A and reproduction in rats. Proc R Soc London Biol Sci 159:510 535, 1964
22. Zelent A, Petkovich M, Mendelsohn C, Leroy P, Krust A, Kastner P, Chambon P: The family of retinoic acid nuclear receptors. In: Saurat J-H (ed.). Retinoids Ten Years On. S Karger, Basel, 1991, pp. 10-27.