Does muscle creatine phosphokinase have access to the total pool of phosphocreatine plus creatine?

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 274, Issue 3 43-3, 1998, Pages

  Hochachka, Peter W ^a   Mossey, Mark K P ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Creatine compartmentalization; Creatine shuttles; Fish muscle phosphagen; Muscle energetics; Muscle phosphagen

Indexed keywords

CARBON 14; CREATINE; CREATINE KINASE; CREATINE PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXERCISE; EXHAUSTION; FAST MUSCLE; FEMALE; MALE; METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAINBOW TROUT; SWIMMING;

EID: 0031918210     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.274.3.r868     Document Type: Article

References (30)

1. Arthur, P. G., T. G. West, R. W. Brill, P. M. Schulte, and P. W. Hochachka. Recovery metabolism in tuna white muscle: rapid and parallel changes of lactate and phosphocreatine after exercise. Can. J. Zool. 70: 1230-1239, 1992.
2. Bangsbo, J., L. Johansen, B. Quistorff, and B. Saltin. NMR and analytic biochemical evaluation of creatine phosphate and nucleotides in the human calf muscle during muscle contraction. J. Appl. Physiol. 74: 2034-2039, 1993.
3. Bessman, S. P., and P. J. Geiger. Transport of energy in muscle: the phosphorylcreatine shuttle. Science 211: 448-452, 1981.
4. Buck, L. T., S. C. Land, and P. W. Hochachka. Anoxia-tolerant hepatocytes: a model system for the study of reversible metabolic suppression. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R49-R56, 1993.
5. Connett, R. J. Analysis of metabolic control: new insights using scaled creatine kinase model. Am. J. Physiol. 254 (Regulatory Integrative Comp. Physiol. 23): R949-R959, 1988.
6. Coombs, C. A., and W. R. Ellington. Graded intracellular acidosis produces extensive and reversible reductions in the effective free energy of ATP hydrolysis in a molluscan muscle. J. Comp. Physiol. [B] 165: 203-212, 1995.
7. Danulat, E., and P. W. Hochachka. Creatine turnover in fish. Fish Physiol. Biochem. 6: 1-9, 1989.
8. Dobson, G. P., W. S. Parkhouse, and P. W. Hochachka. Regulation of anaerobic ATP-generating pathways in trout fast-twitch skeletal muscle. Am. J. Physiol. 253 (Regulatory Integrative Comp. Physiol. 22): R186-R194, 1987.
9. 1H-NMR spectroscopy of small volume elements in human brain at 1.5T. Magn. Reson. Med. 15: 320-326, 1990.
10. Kreis, R., R. Slotboom, J. Felblinger, B. Jung, and C. Boesch. Can proton MRS detect changes in phosphocreatine? (Abstract). Proc. Int. Soc. Magn. Res. Med. 2: 1338, 1997.
11. Kreis, R., and C. Boesch. Liquid-crystal-like structures of human muscle demonstrated by in vivo observations of direct dipolar coupling in localized proton magnetic resonance spectroscopy. J. Magn. Reson. B 104: 189-192, 1994.
12. ++ on the Keq of the creatine kinase reaction and other phosphate hydrolyses and the phosphate transfer reactions. J. Biol. Chem. 254: 6528-6537, 1979.
13. Lee, Y. C. P., and M. B. Visscher. On the state of creatine in heart muscle. Proc. Natl. Acad. Sci. USA 47: 1510-1515, 1961.
14. 31P-NMR study of Andean natives and lowlanders. J. Appl. Physiol. 70: 1963-1976, 1991.
15. Meyer, R. A., M. J. Kushmerick, and T. R. Brown. Phosphorus nuclear magnetic resonance of fast- and slow-twitch muscle. Am. J. Physiol. 242 (Cell Physiol. 11): C1-C11, 1982.
16. + exchange with the environment after exhaustive exercise in the rainbow trout. J. Exp. Biol. 123: 93-121, 1986.
17. Moyes, C. D., P. M. Schlute, and P. W. Hochachka. Recovery metabolism of trout white muscle: role of the mitochondria. Am. J. Physiol. 262 (Regulatory Integrative Comp. Physiol. 31): R295-R304, 1992.
18. Saks, V., and R. Ventura-Clapier (Editors). Role of coupled creatine kinases. Mol. Cell. Biochem. 133/134: 1-346, 1994.
19. Savabi, F. Free creatine available to the creatine-phosphocreatine shuttle in isolated rat atria. Proc. Natl. Acad. Sci. USA 85: 7476-7480, 1988.
20. Schulte, P. M., C. D. Moyes, and P. W. Hochachka. Integrating metabolic pathways in post-exercise recovery of white muscle. J. Exp. Biol. 166: 181-195, 1992.
21. Shen, D., C. D. Gregory, and M. Dawson. Observation and quantitation of lactate in oxidative and glycolytic fibers of skeletal muscles. Magn. Reson. Med. 36: 30-38, 1996.
22. 1H-creatine signal from human skeletal muscle (Abstract). Proc. Int. Soc. Magn. Res. Med. 2: 1890, 1995.
23. 1H-MRS evaluation of the phosphocreatine-creatine (PCr/Cr) pool in human muscle (Abstract). Proc. Int. Soc. Magn. Res. Med. 2: 1337, 1997.
24. 31P-NMR. Biochim. Biophys. Acta 1133: 115-120, 1992.
25. 31P-NMR during anoxia and recovery. Am. J. Physiol. 256 (Regulatory Integrative Comp. Physiol. 25): R922-R929, 1989.
26. 31P-NMR-measured creatine kinase reaction flux in muscle: a caveat! J. Muscle Res. Cell Motil. 17: 177-181, 1996.
27. Wallimann, T., M. Wyss, D. Brdiczka, K. Nicolay, and H. M. Eppenberger. Intracellular compartmentation, structure, and function of creatine kinase isozymes in tissues with high and fluctuating energy demands: the "phosphocreatine circuit" for cellular energy homeostasis. Biochem. J. 281: 21-40, 1992.
28. 31P-NMR spectroscopy. J. Comp. Physiol. [A] 161: 247-256, 1991.
29. 31P-NMR spectroscopy. Biochim. Biophys. Acta 1276: 71-79, 1996.
30. 31P-NMR studies using creatine analogs. J. Biol. Chem. 270: 12428-12438, 1995.