Overexpression of nm23 protein assessed by color video image analysis in metastatic colorectal cancer: Correlation with reduced patient survival

World Journal of Surgery

Volumn 22, Issue 5, 1998, Pages 484-490

  Berney, Christophe R ^a   Yang, Jia Lin ^b   Fisher, Richard J ^a   Russell, Pamela J ^a   Crowe, Philip J ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION;

ANTIGENS, NEOPLASM; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; MONOMERIC GTP-BINDING PROTEINS; NUCLEOSIDE-DIPHOSPHATE KINASE; PROGNOSIS; SURVIVAL RATE; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0031917961     PISSN: 03642313     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002689900421     Document Type: Article

References (39)

1. Parker, S.L., Tong, T., Bolden, S., Wingo, P.A.: Cancer statistics, 1996. CA Cancer J. Clin. 46:5, 1996
2. Liotta, L.A., Steeg, P.S., Stetler-Stevenson, W.G.: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64:327, 1991
3. Blood, C.H., Zetter, B.R.: Tumor interactions with the vasculature: angiogenesis and tumor metastasis. Biochim. Biophys. Acta 1032:89, 1990
4. Folkman, J.: What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer Inst. 82:4, 1990
5. Duffy, M.J.: The role of proteolytic enzymes in cancer invasion and metastasis. Clin. Exp. Metastasis 70:144, 1992
6. Sinicrope, F.A., Ruan, S.B., Cleary, K.R., Stephens, L.C., Lee, J.J., Levin, B.: bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res. 55:237, 1995
7. Kern, S.E., Fearon, E.R., Tersmette, K.W.F., Enterline, J.P., Leppert, M., Nakamura, Y., White, R., Vogelstein, B., Hamilton, S.R.: Allelic loss in colorectal carcinoma. J.A.M.A. 267:3099, 1989
8. Fearon, E.R., Vogelstein, B.: A genetic model for colorectal tumorigenesis. Cell 67:759, 1990
9. Steeg, P.S., Bevilacqua, G., Kopper, L., Thorgeirsson, U.P., Talmadge, J.E., Liotta, L.A., Sobel, M.E.: Evidence for a novel gene associated with low tumor metastatic potential. J. Natl. Cancer Inst. 80:200, 1988
10. Baker, J.M., Mendola, C.E., Kovesdi, L, Fairhurst, J.L., O'Hara, B., Eddy, R.L., Jr., Shows, T.B., Mathew, S., Murty, V.V.V.S., Chaganti, R.S.K.: Chromosomal localisation and nucleoside diphosphate kinase activity of human metastasis-suppressor genes nm23-l and nm23-2. Oncogene S:497, 1993
11. Gilles, A.M., Presecan, E., Vonica, A., Lascu, I.: Nucleoside diphosphate kinase from human erythrocytes: structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme. J. Biol. Chem. 266:8784, 1991
12. Kantor, J.D., McCormick, B., Steeg, P.S., Zetter, B.R.: Inhibition of cell motility after nm23 transfection of human and murine tumour cells. Cancer Res. 53:1971, 1993
13. Urano, T., Furukawa, K., Shiku, H.: Expression of nm23/NDP kinase proteins on the cell surface. Oncogene 8:1371, 1993
14. Howlett, A.R., Petersen, O.W., Steeg, P.S., Bissell, M.J.: A novel function for the nm23-Hl gene: overexpression in human breast carcinoma cells leads to the formation of basement membrane and growth arrest. J. Natl. Cancer Inst. 86:1838, 1994
15. Barnes, R., Masood, S., Barker, E., Rosengard, A.M., Coggin, D.L., Crowell, T., Richter King, C, Porter-Jordan, K., Wargotz, E.S., Liotta, L.A., Steeg, P.S.: Low nm23 protein expression in infiltrating ductal breast carcinomas correlates with reduced patient survival. Am. J. Pathol. 739:245, 1991
16. Nakayama, H., Yasui, W., Yokozaki, H., Tahara, E.: Reduced expression of nm23 is associated with metastasis of human gastric carcinomas. Jpn. J. Cancer Res. 84:184, 1993
17. Florenes, V.A., Aamdal, S., Myklebost, O., Maelandsmo, G.M., Bruland, O.S., Fodstad, O.: Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression. Cancer Res. 52:6088, 1992
18. Nakayama, T., Ohtsuru, A., Nakao, K., Shima, M., Nakata, K., Watanabe, K., Ishii, N., Kimura, N., Nagataki, S.: Expression in human hepatocellular carcinoma of nucleoside diphosphate kinase, a homologue of the nm23 gene product. J. Natl. Cancer Inst. 84:1349, 1992
19. Zou, M., Shi, Y., Al-Sedairy, S., Farid, N.R.: High levels of nm23 gene expression in advanced stage of thyroid carcinomas. Br. J. Cancer 68:385, 1993
20. Engel, M., Theisinger, B., Seib, T., Seitz, G., Huwer, H., Zang, K.D., Welter, C, Dooley, S.: High levels of nm23-Hl and nm23-H2 messenger RNA in human squamous-cell lung carcinoma are associated with poor differentiation and advanced tumor stages. Int. J. Cancer 55:375, 1993
21. Ayhan, A., Yasui, W., Yokozaki, H., Kitadai, Y., Tahara, E.: Reduced expression of nm23 protein is associated with advanced tumour stage and distant metastases in human colorectal carcinomas. Virchows Arch. [Cell Pathol.] 63:213, 1993
22. Tannapfel, A., Köckerling, F., Katalinic, A., Wittekind, C.: Expression of nm23-Hl predicts lymph node involvement in colorectal carcinoma. Dis. Colon Rectum 38:651, 1995
23. Yamaguchi, A., Urano, T., Fushida, S., Furukawa, K., Nishimura, G., Yonemura, Y., Miyazaki, I., Nakagawara, G., Shiku, H.: Inverse association of nm23-H1 expression by colorectal cancer with liver metastasis. Br. J. Cancer 6S:1020, 1993
24. Okada, K., Urano, T., Goi, T., Baba, H., Yamaguchi, A., Furukawa, K., Shiku, H.: Isolation of human nm23 genomes and analysis of loss of heterozygosity in primary colorectal carcinomas using a specific genomic probe. Cancer Res. 54:3979, 1994
25. Cohn, K.H., Wang, F., Desoto-Lapaix, F., Solomon, W.B., Patterson, L.G., Arnold, M.R., Weimar, J., Feldman, J.G., Levy, A.T., Leone, A., Steeg, P.S.: Association of nm23-Hl allelic deletions with distant metastases in colorectal carcinoma. Lancet 338:122, 1991
26. Leggett, B., Young, J., Buttenshaw, R., Thomas, L., Young, B., Chenevix-Trench, G., Searle, J., Ward, M.: Colorectal carcinomas show frequent allelic loss on the long arm of chromosome 17 with evidence for specific target region. Br. J. Cancer 77:1070, 1995
27. Wang, L., Patel, U., Ghosh, L., Chen, H-C, Banerjee, S.: Mutation in the nm23 gene is associated with metastasis in colorectal cancer. Cancer Res. 53:717, 1993
28. Bafico, A., Varesco, L., De Benedetti, L., Caligo, M.A., Gismondi, V., Sciallero, S., Aste, H., Ferrara, G.B., Bevilacqua, G.: Genomic PCR-SSCP analysis of the metastasis associated nm23-Hl (NME1) gene: a study on colorectal cancer. Anticancer Res. 73:2149, 1993
29. Heide, I., Thiede, C., Poppe, K., de Kant, E., Huhn, C, Rochlitz, C.: Expression and mutational analysis of nm23-Hl in liver metastases of colorectal cancer. Br. J. Cancer 70:1267, 1994
30. Whitelaw, S.C., Northover, J.M.: The nm23 gene and colorectal cancer. Gut 35:141, 1994
31. Cawkwell, L., Lewis, F.A., Quirke, P.: Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction. Br. J. Cancer 70:813, 1994
32. Myeroff, L.L., Markowitz, S.D.: Increased nm23-Hl and nm23-H2 messenger RNA expression and absence of mutations in colon carcinomas of low and high metastatic potential. J. Natl. Cancer Inst. 85:147, 1993
33. Yang, J-L., Ow, K.T., Ham, J.M., Russell, P.J., Crowe, P.J.: Higher expression of oncoproteins c-myc, c-erbB-2/neu, PCNA and p53 in metastasising tumors. Ann. Surg. Oncol. 3:514, 1996
34. Skinner, J.M., Zhao, Y., Coventry, B., Bradley, J.: Video image analysis in pathology. Dis. Markers 77:53, 1993
35. Hermanek, P., Sobin, L.H.: UICC, TNM Classification of Malignant Tumours (4th ed., 2nd rev.). Berlin, Springer, 1992, pp. 47-49
36. Bland, J.M., Douglas, G.A.: Multiple significance tests: the Bonferroni method. B.M.J. 370:170, 1995
37. Bacus, S., Flowers, J.L., Press, M.F., Bacus, J.W., McCarty, K.S.: The evaluation of estrogen receptor in primary breast carcinoma by computer-assisted image analysis. Am. J. Clin. Pathol. 90:233, 1988
38. McClelland, R.A., Finlay, P., Walker, K.J., Nicholson, D., Robertson, J.F.R., Blarney, R.W., Nicholson, R.I.: Automated quantitation of immunocytochemically localized estrogen receptors in human breast cancer. Cancer Res. 50:3545, 1990
39. Tilley, W.D., Lim-Tio, S.S., Horsfall, D.J., Aspinall, J.O., Marshall, V.R., Skinner, J.M.: Detection of discrete androgen receptor epitopes in prostate cancer by immunostaining: measuement by color video image analysis. Cancer Res. 54:4096, 1994