Sphingosylphosphorylcholine stimulates proliferation and upregulates cell surface-associated plasminogen activator activity in cultured human keratinocytes

Journal of Investigative Dermatology

Volumn 110, Issue 3, 1998, Pages 253-258

  Wakita, Hisashi ^a   Matsushita, Kayo ^a   Nishimura, Kenji ^b   Tokura, Yoshiki ^a   Furukawa, Fukumi ^a   Takigawa, Masahiro ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KEIO UNIVERSITY   (Japan)

Author keywords

Sphingolipid; Urokinase; Urokinase receptor

Indexed keywords

PLASMINOGEN ACTIVATOR; SPHINGOLIPID; SPHINGOSINE; UROKINASE; UROKINASE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; DNA SYNTHESIS; EPITHELIZATION; GRANULATION TISSUE; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WOUND HEALING;

EID: 0031917776     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1998.00120.x     Document Type: Article

References (29)

1. Allan EH, Martin TJ: Prostaglandin E2 regulates production of plasminogen activator isoenzymes, urokinase receptor, and plasminogen activator inhibitor-1 in primary cultures of rat calvarial osteoblasts. J Cell Physiol 165:521-529, 1995
2. Coleman DL: Diabetes-obesity syndromes in mice. Diabetes 31:1-6, 1982
3. Del Rosso M, Fibbi G, Dini G, et al: Role of specific membrane receptors in urokinase-dependent migration of human keratinocytes. J Invest Dermatol 94:310-316, 1990
4. Desai NN, Spiegel S: Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines. Biochem Biophys Res Commun 181:361-366, 1991
5. Desai NN, Carlson RO, Mattie ME, et al: Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts. J Cell Biol 121:1385-1395, 1993
6. Gaver RC, Sweeley CC:. Chemistry and metabolism of sphingolipds. 3-axo derivatives of N-acetylsphingosine and N-acetyldihydrosphingosine. J Am Chem Soc 88:3643-3647, 1966
7. Grondahl-Hansen J, Lund LR, Raltkiaer E, Ottevanger V, Dano K: Urokinase- and tissue-type plasminogen activators in keratinocytes during wound reepithelialization in vivo. J Invest Dermatol 90:790-795, 1988
8. Hannun YA: Functions of ceramide in coordinating cellular responses to stress. Sci 274:1855-1859, 1996
9. van Hinsbergh VW, Koolwijk P, Hanemaaijer R: Role of fibrin and plasminogen activators in repair-associated angiogenesis: in vitro studies with human endothelial cells. EXS 79:391-411, 1997
10. Ji L, Zhang G, Uematsu S, Akahori Y, Hirabayashi Y: Induction of apoptotic DNA fragmentation and cell death by natural ceramide. FEBS Lett 358:211-214, 1995
11. Kheradmand F, Folkesson HG, Shum L, Derynk R, Pytela R, Matthay MA: Transforming growtb factor-alpha enhances alveolar epithelial cell repair in a new in vitro model. Am J Physiol 267:L728-L738, 1994
12. Kramer MD, Schaefer B, Reinartz J: Plasminogen activation by human keratinocytes: molecular pathways and cell-biological consequences. Biol Chem Hoppe-Seyler 376:131-141, 1995
13. McNeill H, Jensen PJ: A high-affinity receptor for urokinase plasminogen activator on human keratinocytes: characterization and potential modulation during migration. Cell Regulation 1:843-852, 1990
14. Merrill AH Jr, Nimkar S, Menaldino D, et al: Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochem 28:3138-3145, 1989
15. Morioka S, Lazarus GS, Baird JL, Jensen PJ: Migrating keratinocytes express urokinase-type plasminogen activator. J Invest Dermatol 88:418-423, 1987
16. Osada H, Yamada C, Miwa K, Kono T, Oh-hira M: An assay system for the modulators of plasminogen activation on the cell surface. Thromb Res 62:519-530, 1991
17. Ossowski L: Effect of antisense inhibition of Urokinase receptor on malignancy. Curr Topics Microbiol Immunol 213:101-112, 1996
18. Pepper MS, Montesano R: Proteolytic balance and capillary morphogenesis. Cell Differ Dev 32:319-327, 1990
19. Quax PHA, Boxman ILA, van Kesteren CAM, Verheijen JH, Ponec M: Plasminogen activators are involved in keratinocyte and fibroblast migration in wounded cultutes in vitro. Fibrinolysis 8:221-228, 1994
20. Redlitz A, Plow EF: Receptors for plasminogen and t-PA. An update. Baillieres Clin Haematol 8:313-327, 1995
21. Romer J, Bugge TH, Pyke C, Lund LR, Flick MJ, Degen JL, Dano K: Impaired wound healing in mice with a disrupted plasminogen gene. Nature 2:287-292, 1996
22. Seishima M, Takagi H, Okano Y, Mori S, Nozawa Y: Ganglioside-induced terminal differentiation of human keratinocytes: early biochemical events in signal transduction. Arch Dermatol Res 285:397-401, 1993
23. Spiegel S, Milstien S: Sphingolipid metabolites: members of a new class of lipid second messengers. J Memb Biol 146:225-237, 1995
24. Sun L, Xu L, Henry FA, Spiegel S, Nielsen TB: A new wound healing agent - sphingosylphosphorylcholine. J Invest Dermatol 106:232-237, 1996
25. Tuschil A, Lam C, Haslberger A, Lindley I: Interleukin-8 stimulates calcium transients and promotes epidermal cell proliferation. J Invest Dermatol 9:294-298, 1992
26. Wakita H, Nishimura K, Takigawa M: Composition of tree long-chain (sphingoid) bases in stratum corneum of normal and pathologic human skin conditions. J Invest Dermatol 99:617-622, 1992
27. Wakita H, Tokura Y, Furukawa F, Takigawa M: Staphylococcal enterotoxin B upregulates expression of ICAM-1 molecules on IFN-gamma-treated keratinocytes and keratinocyte cell lines. J Invest Dermatol 105:536-542, 1995
28. Zhang H, Buckley NE, Gibson K, Spiegel S: Sphingosine stimulates cellular proliferation via a PKC-independent pathway. J Biol Chem 265:76-81, 1990
29. Zhang H, Desai NN, Olivera A, Seki T, Brooker G, Spiegel S: Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J Cell Biol 114:155-167, 1991