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Volumn 26, Issue 4, 1998, Pages 299-305

Development of a non-high pressure liquid chromatography assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 ISOENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TESTOSTERONE; TESTOSTERONE DERIVATIVE;

EID: 0031917613     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (40)

References (24)
  • 1
    • 0015520624 scopus 로고
    • On the rate limiting step in microsomal hydroxylation of steroids
    • Bjorkhem I (1972) On the rate limiting step in microsomal hydroxylation of steroids. Eur J Biochem 27:354-363.
    • (1972) Eur J Biochem , vol.27 , pp. 354-363
    • Bjorkhem, I.1
  • 2
    • 0024603850 scopus 로고
    • Metabolism of cyclosporin A: Purification and identification of the rifampin-inducible human liver cytocfarome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily
    • Combalbert J, Fabre I, Dalet I, Derancourt J, Cano J and Maurel P (1989) Metabolism of cyclosporin A: Purification and identification of the rifampin-inducible human liver cytocfarome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily. Drug Metab Dispos 17:197-207.
    • (1989) Drug Metab Dispos , vol.17 , pp. 197-207
    • Combalbert, J.1    Fabre, I.2    Dalet, I.3    Derancourt, J.4    Cano, J.5    Maurel, P.6
  • 3
    • 0025067462 scopus 로고
    • Molecular genetics of the P450 superfamily
    • Gonzalez FJ (1990) Molecular genetics of the P450 superfamily. Pharmacol Ther 45:1-38.
    • (1990) Pharmacol Ther , vol.45 , pp. 1-38
    • Gonzalez, F.J.1
  • 4
    • 0026507870 scopus 로고
    • Human cytochrome P-450 enzymes
    • Guengerich FP (1992) Human cytochrome P-450 enzymes. Life Sci 50:1471-1478.
    • (1992) Life Sci , vol.50 , pp. 1471-1478
    • Guengerich, F.P.1
  • 5
    • 0022998708 scopus 로고
    • Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
    • Guengerich FP, Martin MV, Beaune PH, Kremers P, Wolff T and Waxman DJ (1986) Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. J Biol Chem 261:5051-5060.
    • (1986) J Biol Chem , vol.261 , pp. 5051-5060
    • Guengerich, F.P.1    Martin, M.V.2    Beaune, P.H.3    Kremers, P.4    Wolff, T.5    Waxman, D.J.6
  • 6
    • 0027996327 scopus 로고
    • Terfenadine metabolism in human liver: In vitro inhibition by macrolide antibiotics and azoic antifungals
    • Jurima-Romet M, Crawford K, Cyr T and Inaba T (1994) Terfenadine metabolism in human liver: in vitro inhibition by macrolide antibiotics and azoic antifungals. Drug Metab Dispos 22:849-857.
    • (1994) Drug Metab Dispos , vol.22 , pp. 849-857
    • Jurima-Romet, M.1    Crawford, K.2    Cyr, T.3    Inaba, T.4
  • 8
    • 0023921505 scopus 로고
    • Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs
    • Kronbach T, Fischer V and Meyer UA (1988) Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clin Pharmacol Ther 43:630-635.
    • (1988) Clin Pharmacol Ther , vol.43 , pp. 630-635
    • Kronbach, T.1    Fischer, V.2    Meyer, U.A.3
  • 9
  • 14
    • 0029124814 scopus 로고
    • In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase: Comparison to human liver microsomes and precision-cut liver tissue slices
    • Rodrigues AD, Mulford DJ, Lee RD, Surber BW, Kukulka MJ, Ferrero JL, Thomas SB, Shet MS and Estabrook RW (1995) In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase: Comparison to human liver microsomes and precision-cut liver tissue slices. Drug Metab Dispos 23:765-775.
    • (1995) Drug Metab Dispos , vol.23 , pp. 765-775
    • Rodrigues, A.D.1    Mulford, D.J.2    Lee, R.D.3    Surber, B.W.4    Kukulka, M.J.5    Ferrero, J.L.6    Thomas, S.B.7    Shet, M.S.8    Estabrook, R.W.9
  • 15
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens, and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y and Guengerich FP (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens, and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 270:414-423.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 16
    • 0023778344 scopus 로고
    • Inhibition of steroid 5α-reductase and its effects on testosterone hydroxylation by rat liver microsomal cytochrome P-450
    • Sonderfan AJ and Parkinson A (1988) Inhibition of steroid 5α-reductase and its effects on testosterone hydroxylation by rat liver microsomal cytochrome P-450. Arch Biochem Biophys 265:208-218.
    • (1988) Arch Biochem Biophys , vol.265 , pp. 208-218
    • Sonderfan, A.J.1    Parkinson, A.2
  • 18
    • 0017194085 scopus 로고
    • A highly sensitive radiometric assay for zoxazolamine hydroxylation by liver microsomal cytochrome P-450 and P-448: Properties of the membrane-bound and purified reconstituted system
    • Tomaszewski JE, Jerina DM, Levin W and Conney AH (1976) A highly sensitive radiometric assay for zoxazolamine hydroxylation by liver microsomal cytochrome P-450 and P-448: Properties of the membrane-bound and purified reconstituted system. Arch Biochem Biophys 176:788-798.
    • (1976) Arch Biochem Biophys , vol.176 , pp. 788-798
    • Tomaszewski, J.E.1    Jerina, D.M.2    Levin, W.3    Conney, A.H.4
  • 19
    • 0023929834 scopus 로고
    • Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P450 enzyme
    • Waxman DJ, Attisano C, Guengerich FP and Lapenson DP (1988) Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P450 enzyme. Arch Biochem Biophys 263:424-436.
    • (1988) Arch Biochem Biophys , vol.263 , pp. 424-436
    • Waxman, D.J.1    Attisano, C.2    Guengerich, F.P.3    Lapenson, D.P.4
  • 21
    • 0021112308 scopus 로고
    • 19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes
    • 19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes. J Biol Chem 258:8839-8847
    • (1983) J Biol Chem , vol.258 , pp. 8839-8847
    • Wood, A.W.1    Ryan, D.E.2    Thomas, P.E.3    Levin, W.4
  • 22
    • 0026750647 scopus 로고
    • The human hepatic cytochromes P450 involved in drug metabolism
    • Wrighton SA and Stevens JC (1992) The human hepatic cytochromes P450 involved in drug metabolism. Crit Rev Toxicol 22:1-21.
    • (1992) Crit Rev Toxicol , vol.22 , pp. 1-21
    • Wrighton, S.A.1    Stevens, J.C.2
  • 24
    • 0027168405 scopus 로고
    • Oxidation of the antihistaminic drug terfenadine in human liver microsomes: Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation
    • Yun C-H, Okerholm RA and Guengerich FP (1993) Oxidation of the antihistaminic drug terfenadine in human liver microsomes: Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation. Drug Metab Dispos 21:403-409.
    • (1993) Drug Metab Dispos , vol.21 , pp. 403-409
    • Yun, C.-H.1    Okerholm, R.A.2    Guengerich, F.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.