Hepatic immunopotentiation by galactose-entrapped liposomal IL-2 compound in the treatment of liver metastases

Surgery Today

Volumn 28, Issue 1, 1998, Pages 64-69

  Okuno, Kiyotaka ^a   Nakamura, Katsuhito ^a   Tanaka, Akira ^a   Yachi, Kiyoto ^b   Yasutomi, Masayuki ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Galactose residue; Hepatic immunity; Interleukin 2; Liposome; Liver Metastasis

Indexed keywords

GALACTOSE; IMMUNOLIPOSOME; RECEPTOR PROTEIN; RECOMBINANT INTERLEUKIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLON ADENOCARCINOMA; COLORECTAL CANCER; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG FORMULATION; IMMUNOPOTENTIATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER METASTASIS; LIVER SINUSOID; LYMPHOCYTE; MALE; MOUSE; NONHUMAN;

EID: 0031917397     PISSN: 09411291     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02483610     Document Type: Article

References (13)

1. Okuno K, Hirohata T, Nakamura K, Jinnai H, Shigeoka H, Koh K, Shindo K, Yasutomi M (1993) Hepatic arterial infusions of interleukin-2 (IL-2)-hased immunochemotherapy in the treatment of unresectable liver metastases from colorectal cancer. Clin Ther 15:672-683
2. Okuno K, Yasutomi M (1995) Locoregional immunochemotherapy in liver carcinoma. Present and future. Hepato-Gastroenterol 42:578-586
3. Yachi K, Harashima H, Kikuchi H, Sudo R, Yamauchi H, Ebihara K, Matsuo K, Funato K, Kiwada H (1996) Biopharmaceutical evaluation of the liposomes prepared by rehydration of freeze-dried empty liposomes with an aqueous solution of a drug. Biochim Drug Disposit 17:589-605
4. Olson F, Hunt CA, Szoka FC, Vail WJ, Papahadjopoulos D (1979) Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes. Biochim Biophys Acta 557:9-28
5. Yamauchi H, Kikuchi H, Sawada M, Tomikawa M, Hirota S (1994) Characterization and tissue distribution of liposomes containing lactose mono-fatty acid derivatives. J Microencapsulat 11:179-188
6. Bouwens L, Jacobs R, Remels L, Wisse E (1989) Natural cytotoxicity of rat hepatic natural killer cells and macrophages against a syngeneic colon carcinoma. Cancer Immunol Immunother 27: 137-141
7. Okuno K, Takagi H, Nakamura T, Nakamura Y, Iwasa Z, Yasutomi M (1986) Treatment for unresectable hepatome via selective hepatic arterial infusion of lymphokine-activated killer cells generated from autologous spleen cells. Cancer 58:1001-1006
8. Okuno K, Jinnai H, Lee YS, Nakamura K, Hirohata T, Shigeoka H, Yasutomi M (1995) A high level of prostaglandin E2 in the portal vein suppresses liver-associated immunity and promotes liver metastases. Surg Today 25:954-958
9. Anderson PM, Katsanis E, Leonard AS, Schow D, Loffler CM, Goldstein MB, Ochoa AC (1990) Increased local antitumor effects of interleukin-2 liposomes in mice with MCA-106 sarcoma pulmonary metastases. Cancer Res 50:1853-1856
10. Konno H, Yamashita A, Tadakuma T, Sakaguchi S (1991) Inhibition of growth of rat hepatoma by local injection of liposomes containing recombinant interleukin-2. Biotherapy 3:211-218
11. Ashwell G, Morewell AG (1974) The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins. Adv Enzymol 41:99-128
12. Ghosh P, Kantdas P, Bachhawat BK (1982) Targeting of liposomes towards different cell types of rat liver through the involvements of liposomal surface glycosides. Arch Biochem Biophys 926:266-270
13. Dragsten PR, Mitchell DB, Covert G, Baker T (1987) Drug delivery using vesicles targeted to the hepatic asialoglycoprotein receptor. Biochim Biophys Acta 926:270-279