Bone morphogenetic protein 2-coated porous poly-L-lactic acid scaffolds: Release kinetics and induction of pluripotent C3H10T1/2 cells

Tissue Engineering

Volumn 4, Issue 1, 1998, Pages 35-51

  Kim, Hyun D ^a   Smith, Jonathan G ^a   Valentini, Robert F ^a,b,c  

^a Department of Molecular Pharmacology ^*  (United States)

^b BROWN UNIVERSITY   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN GEL; COLLAGEN TYPE 1; OSTEOCALCIN; POLYLACTIC ACID; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; IMMUNOFLUORESCENCE; IN VITRO STUDY; LEACHING; MESENCHYME CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SPONGE; STEM CELL;

EID: 0031917396     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.1998.4.35     Document Type: Article

References (39)

1. Hollinger, J.O., and Battistone, G.C. Biodegradable bone repair materials, synthetic polymers and ceramics. Clin. Orthoped. Relat. Res. 207, 290, 1986.
2. Coombes, A.G., and Meikle, M.C. Resorbable synthetic polymers as replacements for bone graft. Clin. Mater. 17, 35, 1995.
3. Migliaresi, C., Fambri, L., and Cohn, D. A study on the in vitro degradation of poly-lactic acid. J. Biomater. Sci. Polymer. Educ. 5, 591, 1994.
4. Mikos, A.G., Sarakinos, G., Leite, S.M., Vacanti, J.P., and Langer, R. Laminated three-dimensional biodegradable foams for use in tissue engineering. Biomaterials 14, 323, 1993.
5. Mikos, A.G., Thorsen, A.J., Czerwonka, L.A., Bao, Y., Langer, R., Winslow, D.N., and Vacanti, J.P. Preparation and characterization of poly(L-lactic acid) foams. Polymer 35, 1068, 1994.
6. Lo, H., Ponticello, M.S., and Leong, K.W. Fabrication of controlled release biodegradable foams by phase separation. Tissue Eng. 1, 15, 1995.
7. Devin, J.E., Attawia, M.A., and Laurencin, C.T. Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair. J. Biomater. Sci. Polym. Ed. 7, 661, 1996.
8. Freed, L.E., Marquis, J.C., Nohria, A., Emmanual, J., Mikos, A.G., and Langer, R. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. J. Biomed. Mater. Res. 27, 11, 1993.
9. Kim, W.S., Vacanti, C.A., Upton, J., and Vacanti, J.P. Bone defect repair with tissue engineered cartilage. Plast. Reconstr. Surg. 94, 580, 1994.
10. Schugens, C., Grandfils, C., Jerome, R., Teyssie, P., Delree, P., Malgrange, B., and Moonen, G. Preparation of a macroporous biodegradable polylactide implant for neuronal transplantation. J. Biomed. Mater. Res. 29, 1349, 1995.
11. Wald, H.L., Sarakinos, G., Lyman, M.D., Mikos, A.G., Vacanti, J.P., and Langer, R. Cell seeding in porous transplantation devices. Biomaterials 14, 270, 1993.
12. Mooney, D.J., Kaufmann, P.M., Sano, K., McNamara, K., Vacanti, J.P., and Langer, R. Transplantation of hepatocytes using porous, biodegradable sponges. Transplant. Proc. 26, 3425, 1994.
13. Wake, M.C., Partick, C.W., and Mikos, A.G. Pore morphology effects in the fibrovascular tissue ingrowth in porous polymer substrates. Cell Transplant. 3, 339, 1994.
14. Mooney, D.J., Organ, G., Vacanti, J.P., and Langer, R. Design and fabrication of biodegradable polymer devices to engineer tubular tissues. Cell Transplant. 3, 203, 1994.
15. Rivard, C.H., Chaput, C.J., DesRosiers, E.A., Yahia, L.H., and Selmani, A. Fibroblast seeding and culture in biodegradable porous substrates. J. Appl. Biomater. 6, 65, 1995.
16. Yaszemski, M.J., Payne, R.G., Hayes, W.C., Langer, R.S., Aufdemorte, T.B., and Mikos, A.G. The ingrowth of new bone tissue and initial mechanical properties of a degrading polymeric composite scaffold. Tissue Eng. 1, 41, 1995.
17. Laurencin, C.T., Norman, M.E., Elgendy, H.M., el-Amin, S.F., Allcock, H.R., Pucher, S.R., and Ambrosio, A.A. Use of polyphosphazenes for skeletal tissue regeneration. J. Biomed. Mater. Res. 27, 963, 1993.
18. Luyten, F.P., Chen, P., Paralkar, V., and Reddi, A.H. Recombinant bone morphogenetic protein-4, transforming growth factor-β1, and activin a enhance the cartilage phenotype of articular chondrocytes in vitro. Exp. Cell Res. 210, 224, 1994.
19. Gitelman, S.E., Kirk, M., Ye, J.Q., Filvaroff, E.H., Kahn, A.J., and Derynck, R. Vgr-l/BMP-6 induces osteoblastic differentiation of pluripotent mesenchymal cells. Cell Growth Differentiation 6, 827, 1995.
20. Paralkar, V.M., Weeks, B.S., Yu, Y.M., Kleinman, H.K., Reddi, A.H. Recombinant human bone morphogenetic protein 2b stimulates PC12 cell differentiation: Potentiation and binding to type IV collagen. J. Cell Biol. 119, 1721, 1992.
21. Wang, E.A., Rosen, V., D'Alessandro, J.S., Baundy, M., Cordes, P., Harada, T., Israel, D.I., Hewick, R.M., Kerns, K.M., LaPan, P., et al., Recombinant human bone morphogenetic protein induces bone formation. Proc. Natl. Acad. Sci. U.S.A. 87, 2220, 1990.
22. Lee, S.C., Shea, M., Battle, M.A., Kozitza, K., Ron, E., Turek, T., Schaub, R.G., and Hayes, W.C. Healing of large segmental defects in rat femura is aided by rhBMP-2 in PLGA matrix. J. Biomed. Mater. Res. 28, 1149, 1994.
23. Yasko, A.W., Lane, J.M., Fellinger, E.J., Rosen, V., Wozney, J.M., and Wang, E.A. The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). J. Bone Joint Surg. Am. 74-A, 659, 1992.
24. Mayer, M., Hollinger, J., Ron, E., and Wozney, J. Maxillary alveolar cleft repair in dogs using recombinant human bone morphogenetic protein-2 and a polymer carrier. Plast. Reconstr. Surg. 98, 247, 1996.
25. Kenley, R., Marden, L., Turek, T., Jin, L., Ron, E., and Hollinger, J.O. Osseous regeneration in the rat calvarium using novel delivery systems for recombinant human bone morphogenetic protein-2. J. Biomed. Mater. Res. 28, 1139, 1994.
26. Chen, T.L., Bates, R.L., Dudley, A., Hammonds, R.G., and Amento, E.P. Bone morphogenetic protein-2b stimulation of growth and osteogenic phenotypes in rat osteoblast-like cells: Comparison with TGF-β1. J. Bone Miner. Res. 6, 1387, 1991.
27. Ahrens, M., Ankenbauer, T., Schroder, D., Hollnagel, A., Mayer, H., Gross, G. Expression of human bone morphogenetic proteins-2 or -4 in murine mesenchymal progenitor C3H10T1/2 cells induces differentiation into distinct mesenchymal cell lineages. DNA Cell Biol. 12, 871, 1993.
28. Wang, E.A., Israel, D.I., Kelly, S., and Luxenberg, O.P. Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. Growth Factors 9, 57, 1993.
29. Bruder, S.P., Fink, D.J., and Caplan, A.I. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J. Cell Biochem. 56, 283, 1994.
30. Katagiri, T., Yamaguchi, A., Ikeda, T., Yoshiki, S., Wozney, J.M., Rosen, V., Wang, E.A., Tanaka, H., Omura, S., Suda, T. The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem. Biophys. Res. Commun. 172, 295, 1990.
31. Nicoll, S.B., Denker, A.E., and Tuan, R.S. In vitro characterization of transforming growth factor β1-loaded composites of biodegradable polymer and mesenchymal cells. Cells Mater. 5, 231, 1995.
32. Ishaug, S.L., Yaszemski, M.J., Bizios, R., and Mikos, A.G. Osteoblast function on synthetic biodegradable polymers. J. Biomed. Mater. Res. 28, 1445, 1994.
33. Attawia, M.A., Devin, J.E., and Laurencin, C.T. Immunofluorescence and confocal laser scanning microscopy studies of osteoblast growth and phenotypic expression in three-dimensional degradable synthetic matrices. J. Biomed. Mater. Res. 29, 843, 1995.
34. Marden, L.J., Hollinger, J.O., Chaudhari, A., Turek, T., Schaub, R.G., and Ron, E. Recombinant human bone morphogenetic protein-2 is superior to demineralized bone matrix in repairing craniotomy defects in rats. J. Biomed. Mater. Res. 28, 1127, 1994.
35. Hollinger, J.O., Leong, K. Poly(α-hydroxy acids): Carriers for bone morphogenetic proteins. Biomaterials 17, 187, 1996.
36. Kim, H.D., Smith, J.G., and Valentini, R.F. Bone morphogenetic protein-2 induction of pluripotent C3H10T1/2 cells in porous PLLA scaffolds. Transactions of the 43rd Annual Meeting of the Orthopaedic Research Society, Vol. 22, San Francisco, California, 1997, p. 546.
37. Robinson, B.P., Hollinger, J.O., Szachowicz, E.H., and Brekke, J. Calvarial bone repair with porous D,L-polylac-tide. Otolaryngol. Head Neck Surg. 112, 707, 1995.
38. Uludag, H., Timony, G., D'Augusta, D., Blake, C., Palmer, R., Hammerstone, K., and Wozney, J. In vivo delivery of rhBMP-2 using collagen sponges. Proceedings of the 1996 Meeting of the Controlled Release Society, Advances in Controlled Delivery, Baltimore, Maryland, 1996, pp. 51-52.
39. Kim, H.D., and Valentini, R.F. Enhanced retention of rhBMP-2 by porous scaffolds fabricated from derivatized hyaluronic acid. Transactions of the 23rd Annual Meeting of the Society for Biomaterials, New Orleans, Louisiana, 1997. p. 347.