Genetic therapies for xenotransplantation

Journal of the American College of Surgeons

Volumn 186, Issue 4, 1998, Pages 388-396

  Lin, Shu S ^a   Platt, Jeffrey L ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENE THERAPY; GRAFT SURVIVAL; HUMAN; IMMUNE RESPONSE; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; SWINE; TISSUE TRANSPLANTATION; XENOTRANSPLANTATION;

ANIMALS; ANTIGEN-ANTIBODY REACTIONS; COMPLEMENT ACTIVATION; GENETIC ENGINEERING; GRAFT REJECTION; IMMUNITY, CELLULAR; SWINE; TRANSPLANTATION, HETEROLOGOUS; ZOONOSES;

EID: 0031917228     PISSN: 10727515     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1072-7515(98)00054-4     Document Type: Article

References (63)

1. Evans RW. Executive Summary. The National Cooperative Transplantation study. Seattle: Battelle Human Affairs Research Centers; 1991.
2. Starzl TE, Fung J, Tzakis A, et al. Baboon-to-human liver transplantation. Lancet 1993;341:65-71.
3. Platt JL. Hyperacute Xenograft Rejection. New York: Springer-Verlag; 1995.
4. Cooper DKC, Human PA, Lexer G, et al. Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon. J Heart Transplant 1988;7:238-246.
5. Platt JL, Fischel RJ, Matas AJ, et al. Immunopathology of hyperacute xenograft rejection in a swine-to-primate model. Transplantation 1991;52:214-220.
6. Platt JL, Turman MA, Noreen HJ, et al. An ELISA assay for xenoreactive natural antibodies. Transplantation 1990;49: 1000-1001.
7. Calne RY. Organ transplantation between widely disparate species. Transplant Proc 1970;2:550-556.
8. Sandrin MS, Vaughan HA, Dabkowski PL, and McKenzie IFC. Anti-pig IgM antibodies in human serum react predominantly with Galα(1-3)Gal epitopes. Proc Natl Acad Sci USA 1993;90:11391-11395.
9. Good AH, Cooper DKC, Malcolm AJ, et al. Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans. Transplant Proc 1992;24:559-562.
10. Collins BH, Parker W, and Platt JL. Characterization of porcine endothelial cell determinants recognized by human natural antibodies. Xenotransplantation 1994;1:36-46.
11. Parker W, Bruno D, Holzknecht ZE, and Platt JL. Xenoreactive natural antibodies: isolation and initial characterization. J Immunol 1994;153:3791-3803.
12. Lin SS, Kooyman DL, Daniels LJ, et al. The role of natural anti-Galα1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants. Transpl Immunol 1997;5:212-218.
13. Alvarado CG, Cotterell AH, McCurry KR, et al. Variation in the level of xenoantigen expression in porcine organs. Transplantation 1995;59:1589-1596.
14. Thall AD, Maly P, and Lowe JB. Oocyte Galα1-3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse. J Biol Chem 1997;270:21437-21440.
15. Sandrin MS, Fodor WL, Mouhtouris E, et al. Enzymatic remodelling of the carbohydrate surface of a xenogeneic cell substantially reduces human antibody binding and complement-mediated cytolysis. Nat Med 1995;1:1261-1267.
16. Sharma A, Okabe JF, Birch P, et al. Reduction in the level of gal (α1,3) gal in transgenic mice and pigs by the expression of an α(1,2) fucosyltransferase. Proc Natl Acad Sci USA 1996;93:7190-7195.
17. Platt JL, Vercellotti GM, Dalmasso AP, et al. Transplantation of discordant xenografts: a review of progress. Immunol Today 1990;11:450-456.
18. Dalmasso AP, Vercellotti GM, Platt JL, and Bach FH. Inhibition of complement-mediated endothelial cell cytotoxicity by decay accelerating factor: potential for prevention of xenograft hyperacute rejection. Transplantation 1991;52:530-533.
19. Miyagawa S, Hirose H, Shirakura R, et al. The mechanism of discordant xenograft rejection. Transplantation 1988;46: 825-830.
20. White D, and Wallwork J. Xenografting: probability, possibility, or pipe dream? Lancet 1993;342:879-880.
21. Platt JL, and Logan JS. Use of transgenic animals in Xenotransplantation. Transplant Rev 1996;10:69-77.
22. Cozzi E, and White DJG. The generation of transgenic pigs as potential organ donors for humans. Nat Med 1995;1:964-966.
23. McCurry KR, Kooyman DL, Alvarado CG, et al. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat Med 1995;1:423-427.
24. Byrne GW, McCurry KR, Martin MJ, et al. Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage. Transplantation 1997;63:149-155.
25. Cozzi E, Yannoutsos N, Langford GA, et al. Effect of transgenic expression of human decay-accelerating factor on the inhibition of hyperacute rejection of pig organs. In: Cooper DKC, Kemp E, Platt JL, and White DJG, eds. Xenotransplantation: The Transplantation of Organs and Tissues Between Species. Berlin: Spring-er-Verlag; 1997:665-682.
26. Leventhal JR, Matas AJ, Sun LH, et al. The immunopathology of cardiac xenograft rejection in the guinea pig to rat model. Transplantation 1993;56:1-8.
27. Porter KA. Renal transplantation. In: Heptinstall RH, ed. Pathology of the Kidney, Vol III. Boston: Little, Brown, and Company; 1992:1799-1933.
28. Magee JC, Collins BH, Harland RC, et al. Immunoglobulin prevents complement mediated hyperacute rejection in swine-to-primate xenotransplantation. J Clin Invest 1995;96:2404-2412.
29. Lin SS, and Platt JL. Immunologic barriers to xenotransplantation. J Heart Lung Transplant 1996;15:547-555.
30. McPaul JJ, Stastny P, and Freeman RB. Specificities of antibodies eluted from human cadaveric renal allografts. J Clin Invest 1981;67:1405-1414.
31. Paul LC, Claas FHJ, van Es LA, et al. Accelerated rejection of a renal allograft associated with pretransplantation antibodies directed against donor antigens on endothelium and monocytes. N Engl J Med 1979;300:1258-1260.
32. Lin SS, Weidner BC, Lawson JH, et al. Xenoreactive antibodies in the pathogenesis of acute vascular xenograft rejection in pig-to-primate xenografts. J Clin Invest (in press).
33. Perper RJ, and Najarian JS. Experimental renal heterotransplantation. III. Passive transfer of transplantation immunity. Transplantation 1967;5:514-533.
34. Cotterell AH, Collins BH, Parker W, et al. The humoral immune response in humans following cross-perfusion of porcine organs. Transplantation 1995;60:861-868.
35. McCurry KR, Parker W, Cotterell AH, et al. Humoral responses in pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation. Hum Immunol 1997;58:91-105.
36. Parker W, Saadi S, Lin SS, et al. Transplantation of discordant xenografts: a challenge revisited. Immunol Today 1996;17: 373-378.
37. Bach FH, Winkler H, Ferran C, et al. Delayed xenograft rejection. Immunol Today 1996;17:379-384.
38. Goodman DJ, von Albertini M, Willson A, et al. Direct activation of porcine endothelial cells by human natural killer cells. Transplantation 1996;61:763-771.
39. Malyguine AM, Saadi S, Platt JL, and Dawson JR. Human natural killer cells induce morphologic changes in porcine endothelial cell monolayers. Transplantation 1996;61:161-164.
40. Malyguine AM, Saadi S, Holzknecht RA, et al. Induction of procoagulant function in porcine endothelial cells by human NK cells. J Immunol 1997;159:4659-4664.
41. Chopek MW, Simmons RL, and Platt JL. ABO incompatible renal transplantation: initial immunopathologic evaluation. Transplant Proc 1987;19:4553-4557.
42. Ihrcke NS, Wrenshall LE, Lindman BJ, and Platt JL. Role of heparan sulfate in immune system-blood vessel interactions. Immunol Today 1993;14:500-505.
43. Starzl TE, Demetris AJ, Murase N, et al. Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation. Immunol Today 1993;14:326-332.
44. Sachs DH, and Sablinski T Tolerance across discordant xenogeneic barriers. Xenotransplantation 1995;2:234-239.
45. Zhao Y, Swenson K, Sergio JJ, et al. Skin graft tolerance across a discordant xenogeneic barrier. Nat Med 1996;2:1211-1216.
46. Sykes M, Lee LA, and Sachs DH. Xenograft tolerance. Immunol Rev 1994;141:245-276.
47. Li H, Ricordi C, Demetris AJ, et al. Mixed xenogeneic chimerism (mouse + rat → mouse) to induce donor-specific tolerance to sequential or simultaneous islet xenografts. Transplantation 1994;57:592-598.
48. Aksentijevich I, Sachs DH, and Sykes M. Humoral tolerance in xenogeneic BMT recipients conditioned by a nonmyeloablative regimen. Transplantation 1992;53:1108-1114.
49. Gritsch HA, Glaser RM, Emery DW, et al. The importance of nonimmune factors in reconstitution by discordant xenogeneic hematopoietic cells. Transplantation 1994;57:906-917.
50. Inverardi L, Clissi B, Stolzer AL, et al. Overlapping recognition of xenogeneic carbohydrate ligands by human natural killer lymphocytes and natural antibodies. Transplant Proc 1996;28:552.
51. Ljunggren H-G, and Karre K. In search of the 'missing self: MHC molecules and NK cell recognition. Immunol Today 1990;11:237-244.
52. Lanier LL, and Phillips JH. Inhibitory MHC class I receptors on NK cells and T cells. Immunol Today 1996;17:86-91.
53. Lawson JH, and Platt JL. Xenotransplantation: Prospects for Clinical Application. Philadelphia: WB Saunders; 1997.
54. Daggett CW, Yeatman M, Lodge AJ, et al. Total respiratory support from swine lungs in primate recipients. J Thorac Cardiovasc Surg 1998;115:19-27.
55. Akhter SA, Skaer CA, Kypson AP, et al. Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proc Natl Acad Sci USA 1997;94:12100-12105.
56. Kypson AP, Peppel P, Akhter SA, et al. Ex vivo adenoviral-mediated gene transfer to the transplanted adult rat heart. J Thorac Cardiovasc Surg (in press).
57. Lawson JH, and Platt JL. Molecular barriers to xenotransplantation. Transplantation 1996;62:303-310.
58. Lawson JH, Sorrell RD, and Platt JL. Thrombomodulin activity in porcine-to-human xenotransplantation [Abstract]. Circulation 1997;96(suppl):565.
59. Patience C, Takeuchi Y, and Weiss RA. Infection of human cells by an endogenous retrovirus of pigs. Nat Med 1997;3:282-286.
60. Sullenger BA, Gallardo HF, Ungers GE, and Gilboa E. Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication. Cell 1990;63:601-608.
61. Groth CG, Korsgren O, Tibell A, et al. Transplantation of porcine fetal pancreas to diabetic patients. Lancet 1994;344:1402-1404.
62. Chari RS, Collins BH, Magee JC, et al. Treatment of hepatic failure with ex-vivo pig liver perfusion followed by liver transplantation. N Engl J Med 1994;331:234-237.
63. Deacon T, Schumacher J, Dinsmore J, et al. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinsons disease. Nat Med 1997;3:350-353.