Mechanisms of systemic autoimmunity in murine models of SLE

Immunologic Research

Volumn 17, Issue 1-2, 1998, Pages 41-47

  Eisenberg, Robert ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Stellar Chance Laboratories   (United States)

Author keywords

Apoptosis; Autoimmunity; Immunoregulation; Lymphoproliferation; Mouse models; Systemic lupus erythematosus; Tolerance

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELLULAR IMMUNODEFICIENCY; GRAFT VERSUS HOST REACTION; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

EID: 0031917080     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02786429     Document Type: Article

References (31)

1. Cohen PL, Eisenberg RA: Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Ann Rev Immunol 1991;9:243-269.
2. Eisenberg RA, Cohen PL: Class II major histocompatibility antigens and the etiology of systemic lupus erythematosus. Clin Immunol Immunopathol 1983;29:1-6.
3. Andrews BS, Eisenberg RA, Theofilopoulos AN, Izui S, Wilson CB, McConahey PJ, Murphy ED, Roths JB, Dixon FJ: Spontaneous murine lupus-like syndromes clinical and immunopathological manifestations in several strains. J Exp Med 1978;148:1198-1215.
4. Herron LR, Eisenberg RA, Roper E, Kakkanaiah VN, Cohen PL, Kotzin BL: Selection of the T-cell receptor repertoire in Lpr mice. J Immunol 1993;151:3450-3459.
5. Maldonado MA, Eisenberg RA, Roper E, Cohen PL, Kotzin BL: Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I. J Exp Med 1995;181:641-648.
6. Eisenberg RA, Tan EM, Dixon FJ: Presence of anti-Sm reactivity in autoimmune mouse strains. J Exp Med 1978;147:582-587.
7. Elkon KB, Bonfa E, Llovet R, Eisenberg RA: Association between anti-Sm and anti-ribosomal P protein autoantibodies in human systemic lupus erythematosus and MRL/lpr mice. J Immunol 1989;143:1549-1554.
8. Treadwell EL, Cohen P, Williams D, O'Brien K, Volkman A, Eisenberg RA: MRL mice produce anti-Su autoantibody a specific marker for systemic lupus erythematosus. J Immunol 1993;150:695-699.
9. Eisenberg RA, Craven SY, Fisher CL, Morris SC, Rapoport R, Pisetsky DS, Cohen PL: The genetics of autoantibody production in MRL/ lpr lupus mice. Clin Exp Rheumatol 1989;7:S35-40.
10. Watson ML, Rao JK, Gilkeson GS, Ruiz P, Eicher EM, Pisetsky DS, Matsuzawa A, Rochelle JM, Seldin MF: Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease modifying loci. J Exp Med 1992; 176:1645-1656.
11. Cohen PL, Creech E, Nakul-Aquaronne D, McDaniel R, Ackler S, Rapoport RG, et al.: Antigen nonspecific effect of major histocompatibility complex haplotype on autoantibody levels in systemic lupus erythematosus-prone lpr mice. J Clin Invest 1993;91:2761-2768.
12. Nagata S: Apoptosis by death factor. Cell 1997;88:355-365.
13. Izui S, Kelley VE, Masuda K, Yoshida H, Roths JB, Murphy ED: Induction of various autoantibodies by mutant gene lpr in several strains of mice. J Immunol 1984;133:227-233.
14. Roths JB, Murphy ED, Eicher EM: A new mutation gld that produces lymphoproliferation and autoimmunity in C3H/HeJ mice. J Exp Med 1984;159:1-20.
15. Bos NA, Kimura H, Meeuwsen CG, De Visser H, Hazenberg MP, Wostmann BS, et al.: Serum immunoglobulin levels and naturally occuring antibodies against carbohydrate antigens in germ-free BALB/c mice fed chemically deemed ultrafiltered diet. Eur J Immunol 1989;19:2335-2339.
16. Katagiri T, Cohen PL, Eisenberg RA: The lpr gene causes an intrinsic T-cell abnormality that is required for hyperproliferation. J Exp Med 1988;167:741-751.
17. Sobel ES, Cohen PL, Eisenberg RA: lpr T-cells are necessary for autoantibody production in lpr mice. J Immunol 1993;150:4160-4167.
18. Sobel ES, Katagiri T, Katagiri K, Morris SC, Cohen PL, Eisenberg RA: An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimm-unity. J Exp Med 1991;173: 1441-1449.
19. Sobel ES, Kakkanaiah VN, Kakkanaiah M, Cheek RL, Cohen PL, Eisenberg RA: T-B collaboration for autoantibody production in lpr mice is cognate and MHC-restricted. J Immunol 1994;152:6011-6016.
20. Fossati L Sobel ES, Iwamoto M, Cohen PL, Eisenberg RA, Izui S: The Yaa gene-mediated acceleration of murine lupus: Yaa- T-cells from nonautoimmune mice collaborate with Yaa+ ET-cells to produce lupus autoantibodies in vivo. Eur J Immunol 1995;25: 3412-3417.
21. Kakkanaiah VN, Sobel ES, MacDonald GC, Cheek RL, Cohen PL, Eisenberg RA: B cell genotype determines the fine specificity of autoantibody in lpr mice. J Immunol 1997;159:1027-1035.
22. Sobel ES, Kakkanaiah VN, Cohen PL, Eisenberg RA: Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene. Int Immunol 1993; 5:1275-1278.
23. Sobel ES, Kakkanaiah VN, Kakkanaiah M, Cohen PL, Eisenberg RA: Co-infusion of normal bone marrow partially corrects the gld T-cell defect Evidence for an intrinsic and extrinsic role for Fas ligand. J Immunol 1995;154:459-464.
24. MacDonald GC, Kakkanaiah VN, Sobel ES, Cohen PL, Eisenberg RA: In vivo depletion of Thy-1-positive cells originating from normal bone marrow abrogates the suppression of gld disease in normal-gld mixed bone marrow chimeras. J Immunol 1995; 154:444-449.
25. Singer GG, Abbas AK: The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice Immunity 1994; 1:365-371.
26. Eisenberg RA, Craven SY, Warren RW, Cohen PL: Stochastic control of anti-Sm autoantibodies in MRL/ Mp-lpr/lpr mice. J Clin Invest 1987;80:691-697.
27. Licht T Aksentijevich I, Gottesman MM, Pastan I: Efficient expression of functional human MDR1 gene in murine bone marrow after retroviral transduction of purified hematopoietic stem cells. Blood 1995;86:111-121.
28. Snowden JA Biggs JC, Brooks PM: Autologous blood stem cell transplantation for autoimmune diseases. Lancet 1996;348: 1112,1113.
29. van der Veen FM, Rolink AG, Gleichmann E: Autoimmune disease strongly resembling systemic lupus erythematosus (SLE) in F1 mice undergoinggraft-versus-host reaction (GVHR). Adv Exp Med Biol 1982;149:669-677.
30. Morris SC, Cheek RL, Cohen PL, Eisenberg RA: Autoantibodies in chronic graft versus host result from cognate T-B interactions. J Exp Med 1990;171:503-517.
31. Bradley DS, Jennette JC, Cohen PL, Eisenberg RA: Chronic graft versus host disease-associated autoimmune manifestations are independently regulated by different MHC class II loci. J Immunol 1994;152:1960-1969.