Critical importance of in vivo amoxicillin and cefotaxime concentrations for synergy in treatment of experimental Enterococcus faecalis endocarditis

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 2, 1998, Pages 468-470

  Join Lambert, Olivier ^a   Mainardi, Jean Luc ^b   Cuvelier, Catherine ^c   Dautrey, Sophie ^c   Farinotti, Robert ^c   Fantin, Bruno ^a,d   Carbon, Claude ^a  

^a INSERM   (France)

^b SAINT JOSEPH HOSPITAL   (France)

^c BICHAT HOSPITAL   (France)

^d BEAUJON HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; CEFOTAXIME; GENTAMICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL ENDOCARDITIS; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG POTENTIATION; ENTEROCOCCUS FAECALIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RABBIT; ULTRAFILTRATION;

AMOXICILLIN; ANIMALS; CEFOTAXIME; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ENDOCARDITIS, BACTERIAL; ENTEROCOCCUS FAECALIS; GRAM-POSITIVE BACTERIAL INFECTIONS; RABBITS;

EID: 0031916627     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Aslangul, E., M. Baptista, B. Fantin, F. Depardieu, M. Arthur, P. Courvalin, and C. Carbon. 1997. Selection of glycopeptide-resistant mutants of VanB-type Enterococcus faecalis BM4281 in vitro and in experimental endocarditis. J. Infect. Dis. 175:598-605.
2. Craig, W. A., and B. Suh. 1986. Protein binding and the antimicrobial effects: methods for the determination of protein binding, p. 265-293. In V. Lorian (ed.), Antibiotics in laboratory medicine, 2nd ed. The Williams & Wilkins Co., Baltimore, Md.
3. Fontana, R., A. Grossato, M. Ligozzi, and E. A. Tonin. 1990. In vitro response to bactericidal activity of cell wall-active antibiotics does not support the general opinion that enterococci are naturally tolerant to these antibiotics. Antimicrob. Agents Chemother. 34:1518-1522.
4. Ganzinger, U., and A. Haslberger. 1985. Pharmacokinetics of cephalosporins in normal and septicemic rabbits. Antimicrob. Agents Chemother. 28:473-477.
5. Gavalda, J., J. A. Capdevila, C. Torres, M. Laguarda, C. Tenorio, J. de Otero, and A. Pahissa. 1996. Efficacy of ampicillin (A) and ceftriaxone (C) in the treatment of experimental endocarditis due to Enterococcus faecalis highly-resistant to aminoglycosides, abstr. B4, p. 22. In Program and abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
6. Gomeni, R. 1983. An interactive programme for individual and population parameter estimation, p. 1022-1025. In J. H. Van Bemmel, N. Ball, and N. Wigertz (ed.), Medinfo 83. North Holland, Amsterdam, The Netherlands.
7. Jehl, F., C. Caillon, and W. J. Martone. 1990. High performance liquid chromatography of antibiotics. J. Chromatogr. 531:509-548.
8. Krogstad, D. J., and R. C. Moellering. 1986. Antimicrobial combinations, p. 537-595. In V. Lorian (ed.), Antibiotics in laboratory medicine, 2nd ed. The Williams & Wilkins Co., Baltimore, Md.
9. Mainardi, J.-L., L. Gutmann, J. F. Acar, and F. W. Goldstein. 1995. Synergistic effect of amoxicillin and cefotaxime against Enterococcus faecalis. Antimicrob. Agents Chemother. 39:1984-1987.
10. Pearson, R. D., R. T. Steigbigel, H. T. Davis, and S. W. Chapman. 1980. Method for a reliable determination of minimal lethal antibiotic concentrations. Antimicrob. Agents Chemother. 18:699-708.
11. Provost, Y., and R. Farinotti. 1984. Dosage immunologique par polarisation de fluorescence: application aux médicaments. J. Pharmacol. Clin. 3:199-216.
12. Sullam, P. M., T. A. Drake, M. G. Täuber, C. J. Hackbarth, and M. A. Sande. 1985. Influence of the developmental state of valvular lesions on the antimicrobial activity of cefotaxime in experimental enterococcal infections. Antimicrob. Agents Chemother. 27:320-323.
13. Toala, P., A. McDonald, C. Wilcox, and M. Finland. 1969. Susceptibility of group D Streptococcus (enterococcus) to 21 different antibiotics in vitro, with special reference to species differences. Am. J. Med. Sci. 258:416-430.