Detection of an outlier and evaluation of its influence in chronic toxicity studies

Drug Information Journal

Volumn 32, Issue 1, 1998, Pages 201-212

  Hamada, Chikuma ^a   Yoshino, Kei ^b   Abe, Ikumi ^c   Matsumoto, Kazuhiko ^b   Nomura, Mamoru ^d   Yoshimura, Isao ^e  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN TOBACCO INC   (Japan)

^c MITSUBISHI CHEMICAL CORPORATION   (Japan)

^d DAIICHI SANKYO CO   (Japan)

^e TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Outlier; Parametric method and nonparametric method; Studentized residual; Toxicological evaluation

Indexed keywords

ANALYTIC METHOD; CHRONIC TOXICITY; DATA ANALYSIS; DOSE RESPONSE; PRIORITY JOURNAL; REGRESSION ANALYSIS; REVIEW; STATISTICAL ANALYSIS;

EID: 0031916261     PISSN: 00928615     EISSN: None     Source Type: Journal    
DOI: 10.1177/009286159803200128     Document Type: Review

References (8)

1. Editorial Supervision by First Evaluation and Registration Division. Pharmaceutical Affairs Bureau, Ministry of Health and Welfare. Guidelines for Toxicity Studies of Drugs (Commentary). Tokyo: Yakuji Nippo; 1990.
2. Dunnett CW. A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc. 1955;50:1096-1121.
3. Yamazaki M, Noguchi Y, Tanda M, Shintani S. Statistical methods appropriate for general lexicological studies in rats. Algorithms for multiple comparisons of treatment groups with control. J Takeda Res Labs. 1981;40:163-187. (in Japanese).
4. Kobayashi K, Watanabe K, Inoue H. Questioning the usefulness of the non-parametric analysis of quantitative data into ranked data in toxicology studies. J Toxicolog Sci. 1995;20:47-53.
5. Hamada C, et al. A study on the consistency between statistical evaluation and toxicological judgment. Drug Inf J. 1997;31(2):413-421.
6. Weisberg S. Applied Linear Regression. Second Edition. New York: John Wiley and Sons; 1985.
7. SAS Institute Inc. SAS/STAT User's Guide Version 6 Fourth Edition. Gary, NCSAS Institute Inc. 1992.
8. Morris RW, Dietz EJ. How to perform Jonckheere's test using CORR procedure. Proceedings of SITGI14 1337-1339, 1989.