The soluble recombinant form of a binding protein/receptor for the globular domain of C1q (gC1qR) enhances blood coagulation

Blood Coagulation and Fibrinolysis

Volumn 9, Issue 1, 1998, Pages 29-37

  Peerschke, E I B ^a,d   Jesty, J ^b   Reid, K B M ^c   Ghebrehiwet, B ^b  

^a NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

C1q; C1q receptors; Coagulation; Complement receptors

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT RECEPTOR;

ARTICLE; BINDING SITE; BLOOD CLOTTING; COMPLEMENT SYSTEM; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTHROMBIN TIME; THROMBIN TIME; THROMBOSIS;

EID: 0031916078     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-199801000-00004     Document Type: Article

References (27)

1. Blajchman MA, Ozge-Anwar AH. The role of the complement system in hemostasis. Progr Hematol 1986; 14: 149-182.
2. Sundsmo JS, Fair DS. Relationship among the complement, kinin, coagulation, and fibrinolytic systems. Springer Semin Immunopathol 1983; 6: 231-258.
3. Ghebrehiwet B, Silverberg M, Kaplan AP. Activation of the classic pathway of complement by Hagemann factor fragment. J Exp Med 1981; 152: 665-676.
4. Mori K, Nagasawa S. Studies on human high molecular weight (HMW) kininogen. II. Structural changes in HMW kininogen by the action of human plasma kallikrein. J Biochemistry 1981; 89: 1465-1473.
5. Ghebrehiwet B, Peerschke EIB. The C1q-R participates in immunoregulation and signal transduction. Behring Inst Mitt 1993; 93: 236-240.
6. Guan E, Burgess WH, Robinson SL, Goodman EB, McTigue KJ, Tenner AJ. Phagocytic cell molecules that bind the collagen-like region of C1q: involvement in the C1q-mediated enhancement of phagocytosis. J Biochemistry 1981; 89: 1465-1473.
7. Ghebrehiwet B, Lim B-L, Peerschke EIB, Willis AC, Reid KBM. Isolation, c-DNA cloning, and overexpression of a 33-KD cell surface glycoprotein that binds to the globular 'heads' of C1q. J Exp Med 1994; 179: 1809-1821.
8. Erdei A, Reid KBM. The C1q receptor. Molec Immunol 1988; 25: 1067-1073.
9. Malhotra R, Thiel S, Reid KBM, Sim RB. Human leukocyte C1q receptor binds other soluble proteins with collagen domains. J Exp Med 1990; 172: 955-959.
10. Eggleton P, Ghebrehiwet B, Sastry KN, Coburn JP, Zaner KS, Reid KBM, Tauber AI. Identification of gC1q-binding protein (gC1q-R) on the surface of human neutrophils. Subcellular localization and binding properties in comparison with the cC1q-R. J Clin Invest 1995; 95: 1569-1578.
11. Peerschke EIB, Ghebrehiwet B. Identification and partial characterization of human platelet C1q binding sites. J Immunol 1988; 14: 3505-3511.
12. Peerschke EIB, Reid KBM, Ghebrehiwet B. Identification of a novel 33-kDA C1q-binding site on human blood platelets. J Immunol 1994; 152: 5896-5901.
13. Peerschke EIB, Malhotra R, Ghebrehiwet B, Reid KBM, Willis AC, Sim RB. Isolation of a human endothelial cell C1q receptor (C1qR). J Leuk Biol 1993; 53: 179-184.
14. Peerschke EIB, Ghebrehiwet B. Platelet membrane receptors for the complement component C1q. Semin Hematol 1994; 31: 320-328.
15. Peerschke EIB, Reid KBM, Ghebrehiwet B. Platelet activation by C1q results in the induction of alphaIIb/ beta3 integrins (GPIIb-IIIa) and the expression of P-Selectin and procoagulant activity. J Exp Med 1993; 178: 579-587.
16. Daha MR, Miltenburg AMM, Hiemstra PS, Klar-Mohamad N, van E LA, van Hinsbergh VWM. The complement subcomponent C1q mediates binding of immune complexes and aggregates to endothelial cells in vitro. Europ J Immunol 1988; 18: 783-787.
17. Joseph K, Ghebrehiwet B, Peerschke EIB, Reid KBM, Kaplan AP. Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor which binds to the globular 'heads' of C1q (gC1q-R). Proc Natl Acad Sci 1996; 93: 8552-8557.
18. Herwald H, Dedio J, Kellner R, Loos M, Muller-Esterl W. Isolation and characterization of the kininogen-binding protein p33 from endothelial cells. Identity with the gC1q receptor. J Biol Chem 1996; 271: 13040-13047.
19. Lim B-L, Reid KBM, Ghebrehiwet B, Pecrschke EIB, Leigh LAE, Preissner KT. The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor. J Biol Chem 1996; 271: 26739-26744.
20. Shinbayama Y, Joseph K, Ghebrehiwet B, Peerschke EIB, Reid KBM, Kaplan AP. Identification of gC1qR, the endothelial cell receptor for the globular heads of C1q as a naturally occurring initiator of the intrinsic blood coagulation and kinin-generating pathway [abstract]. Blood 1996; 88: 524a.
21. Peterson KL, Zhang W, Keilbaugh SA, Peerschke EIB, Ghebrehiwet B. The C1q-binding cell membrane proteins, cC1q-R and gC1q-R are released from activated cells: subcellular distribution and immunochemical characterization. Clin Immunol Immunopathol 1997; 84: 17-26.
22. Hjort P, Rapaport SI, Owren PA. A simple one-stage prothrombin assay using Russell's viper venom in cephalin suspension. J Lab Clin Med 1955; 46: 89-93.
23. Jesty J, Wun T-C, Lorenz A. Kinetics of the inhibition of factor Xa and the tissue factor-factor VIIa complex by the tissue factor pathway inhibitor in the presence or absence of heparin. Biochemistry 1994; 33: 12686-12694.
24. Mann KG, Krishnaswamy S, Lawson JH. Surface-dependent hemostasis. Semin Hematol 1992; 29: 213-226.
25. Schafer AI. Coagulation cascade: an overview. In: Loscalzo J, Schafer AI (editors). Thrombosis and hemorrhage. Boston, MA: Blackwell Scientific Publications, 1994. pp. 3-12.
26. Schmaier AH. Contact activation. In: Loscalzo J, Schafer AI (editors). Thrombosis and Hemorrhage. Boston, AM: Blackwell Scientific Publications, 1994. pp. 87-105.
27. Tedder TF. Cell surface receptor shedding: a means of regulating function. Am J Respir Cell Mol Biol 1991; 5: 305-306.