Engrafted maternal T cells in human severe combined immunodeficiency: Evidence for a TH2 phenotype and a potential role of apoptosis on the restriction of T-cell receptor variable β repertoire

Journal of Allergy and Clinical Immunology

Volumn 101, Issue 1, 1998, Pages 131-134

  Plebani, Alessandro ^a,c   Stringa, Maddalena ^a   Priglione, Ignazia ^c   Facchetti, Paola ^c   Ghiotto, Fabio ^c   Airoldi, Irma ^c   Giacchino, Raffaella ^b   Cristina, Emilio ^b   Porta, Fulvio ^e   Grossi, Carlo E ^d   Pistoia, Vito ^c  

^a Department of Pediatrics ^*  (Italy)

^b Galliera Hospitals   (Italy)

^c G GASLINI INSTITUTE   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

^e UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN E; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

APOPTOSIS; ARTICLE; CASE REPORT; CHILD; COMBINED IMMUNODEFICIENCY; FEMALE; GENE EXPRESSION; GRAFT VERSUS HOST REACTION; HLA TYPING; HUMAN; IMMUNE DEFICIENCY; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0031915542     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(98)70207-6     Document Type: Article

References (10)

1. O'Reilly RJ, Keever CA, Small TN, Brochstein J. The use of HLA-non-identical T-cell-depleted marrow transplants for correction of severe combined immunodeficiency disease. Immunodeficiency Rev 1989;1:273-309.
2. Knobloch C, Goldmann SF, Friedrich W. Limited T cell receptor diversity of transplacentally acquired maternal T cells in severe combined immunodeficiency. J Immunol 1991;146:4157-64.
3. Sottini A, Quirós-Roldan E, Notarangelo LD, Malagoli A, Primi D, Imberti L. Engrafted maternal T cells in a severe combined immunodeficiency patient express T-cell receptor variable beta segments characterized by a restricted V-D-J junctional diversity. Blood 1995;85:2105-13.
4. Melamed I, Cohen A, Roifman CM. Expansion of CD3 + CD4-CD8-T cell population expressing high levels of IL-5 in Omenn's syndrome. Clin Exp Immunol 1994;95:14-21.
5. Facchetti P, Prigione I, Ghiotto F, Tasso P, Garaventa A, Pistoia V. Functional and molecular characterization of tumor-infiltrating lym-phocytes and clones thereof from a major-histocompatibility complex-negative human tumor: neuroblastoma. Cancer Immunol Immunother 1996;42:170-8.
6. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991;139:271-9.
7. Clark SC, Kamen R. The human hematopoietic colony stimulating factors. Science 1987;236:1229-37.
8. Boussiotis VA, Barber DL, Nakarai T, et al. Prevention of T cell anergy by signalling through the γc chain of the IL-2-receptor. Science 1994;226:1039-42.
9. Go C, Lancki DW, Fitch FW, Miller J. Anergized T cell clones retain their cytolytic ability. J Immunol 1993;150:367-76.
10. Krenger W, Snyder KM, Byon JCH, Falzarano G, Ferrara JLM. Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease. J Immunol 1995;155:585-93.