Long-term alleviation of allodynia-like behaviors by intrathecal implantation of bovine chromaffin cells in rats with spinal cord injury

Pain

Volumn 74, Issue 2-3, 1998, Pages 115-122

  Yu, Wei ^a   Hao, Jing Xia ^a   Xu, Xiao Jun ^a   Saydoff, Joel ^b   Haegerstrand, Anders ^c   Hökfelt, Tomas ^d   Wiesenfeld Hallin, Zsuzsanna ^a  

^a Div Clin Neurophysiol   (Sweden)

^b CytoTherapeutics Inc   (United States)

^c ASTRAZENECA R AND D   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Allodynia; Chromaffin cell; Opioid receptors; Spinal cord injury; Adrenergic receptors

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; CATECHOLAMINE; ENKEPHALIN; NALOXONE; OPIATE RECEPTOR; PHENTOLAMINE; TYROSINE 3 MONOOXYGENASE;

ALLODYNIA; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMAFFIN CELL; CHRONIC PAIN; COLD; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; IMMUNOHISTOCHEMISTRY; LUMBAR SPINE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY;

EID: 0031915327     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(97)00204-2     Document Type: Article

References (43)

1. Boivie, J., Central pain. In: P.D. Wall and R. Melzack (Eds.), Textbook of Pain, Churchill Livingstone, London, 1994, pp. 871-892.
2. Ginzburg R., Seltzer Z. Subarachnoid spinal cord transplantation of adrenal medulla suppresses chronic neuropathic pain behavior in rats. Brain Res. 523:1990;147-150.
3. Haegerstrand A., Gillis G., Bengtsson L. Serial cultivation of adult human endothelium from the great saphenous vein. J. Vascul. Surg. 16:1992;280-285.
4. Hama A.T., Sagen J. Reduced pain-related behavior by adrenal medullary transplants in rats with experimental painful peripheral neuropathy. Pain. 52:1993;223-231.
5. Hama, A.T. and Sagen, J., Alleviation of neuropathic pain symptoms by xenogeneic chromaffin cell grafts in the spinal subarachnoid space, Brain Res., 651 (1994a) 183-193.
6. Hama, A.T. and Sagen, J., Induction of spinal NADPH-diaphorase by nerve injury is attenuated by adrenal medullary transplants, Brain Res., 640 (1994b) 345-351.
7. Hama A.T., Pappas G.D., Sagen J. Adrenal medullary implants reduce transsynaptic degeneration in the spinal cord of rats following chronic constriction nerve injury. Exp. Neurol. 137:1996;81-93.
8. Hama A.T., Unnerstall J.R., Siegan J.B., Sagen J. Modulation of NMDA receptor expression in the rat spinal cord by peripheral nerve injury and adrenal medullary grafting. Brain Res. 687:1995;103-113.
9. Hao, J.-X. and Xu, X.-J., Treatment of a chronic allodynia-like response in spinally injured rats: effects of systemically administered excitatory amino acid receptor antagonists, Pain, 66 (1996a) 279-285.
10. Hao, J.-X. and Xu, X.-J., Treatment of a chronic allodynia-like response in spinally injured rats: effects of systemically administered nitric oxide synthase inhibitors, Pain, 66 (1996b) 313-319.
11. Hao J.-X., Yu W., Xu X.-J., Wiesenfeld-Hallin Z. Effects of intrathecal versus systemic clonidine in treating chronic allodynia-like response in spinally injured rats. Brain Res. 736:1997;28-34.
12. Johnson D.G., de C. Nourueira Araujo G.M. A simple method of reducing the fading of immunofluorescence during microscopy. J. Immunol. Methods. 43:1981;249-350.
13. Joseph J., Goddard M., Mills J., Padrun V., Zurn A., Zeilinski B., Favre J., Gardaz J., Mosimann F., Sagen J., Christenson L., Aebischer P. Transplantation of encapsulated bovine chromaffin cells in the sheep subarachnoid space: a preclinical study for the treatment of cancer pain. Cell Transplant. 3:1994;355-364.
14. Kaplan F.A., Kreuger P.M., Harvey J., Goddard M.B. Peripheral xenogenic immunological response to encapsulated bovine chromaffin adrenal cells implanted within the sheep intrathecal space. Transplantation. 61:1996;1215-1221.
15. Lazorthes, Y., Pappas, G.D., Cibes, J., Sagen, J., Tafani, M., Winnie, A.P. and Tkaczuk, J., Human chromaffin cell therapy for cancer pain: clinical, biochemical and anatomical data with long-term follow-up. Abstr. 8th World Congress on Pain, IASP Press, Seattle, WA, 1996, p. 13.
16. Livett B.G., Dean D.M., Whelan L.G., Udenfriend S., Rossier J. Co-release of enkephalin and catecholamines from cultured adrenal chromaffin cells. Nature. 289:1981;317-319.
17. Markey K.A., Kondo H., Shenkman L., Goldstein M. Purification and characterization of tyrosine hydroxylase from a clonal pheochromacytome cell line. Mol. Pharmacol. 17:1980;79-85.
18. Ortega-Alvaro A., Gibert-Rahola J., Chover A., Tejedor-Real P., Casas J., Mico A. Effect of amitriptyline on the analgesia induced by adrenal medullary tissue transplanted in the rat spinal subarachnoid space. Exp. Neurol. 130:1994;9-14.
19. Pacheco-Cano M., Garcia-Hernandez F., Hiriart M., Komisaruk B., Drucker-Colin R. Dibutyryl cAMP stimulates analgesia in rats bearing a ventricular adrenal medulla transplant. Brain Res. 531:1990;290-293.
20. Platt J.L., Michael A.F. Retardation of fading and enhancement of intensity of immunofluorescence by p-paraphenylenediamine. J. Histochem. Cytochem. 31:1983;840-842.
21. Sagen J., Kemmler J.E. Increased levels of met-enkephalin-like immunoreactivity in the spinal cord CSF of rats with adrenal medullary transplants. Brain Res. 502:1989;1-10.
22. Sagen J., Kemmler J.E., Wang H. Adrenal medullary transplants increase spinal cord CSF catecholamine levels and reduce pain sensitivity. J. Neurochem. 56:1991;623-627.
23. Sagen, J., Pappas, G.D. and Perlow, M.J., Adrenal medullary tissue transplants in the rat spinal cord reduce pain sensitivity, Brain Res., 384 (1986a) 189-194.
24. Sagen, J., Pappas, G.D. and Pollard, H.B., Analgesia induced by isolated bovine chromaffin cells implanted in rat spinal cord, Proc. Natl. Acad. Sci. USA, 83 (1986b) 7522-7526.
25. Sagen J., Wang H., Pappas G.D. Adrenal medullary implants in the rat spinal cord reduce nociception in a chronic pain model. Pain. 42:1990;69-79.
26. Saitoh, Y., Taki, T., Arita, N., Ohnishi, T. and Hayakawa, T., Analgesia induced by transplantation of encapsulated tumor cells secreting β-endorphin, J. Neurosurg, 82 (1995) 630-634.
27. Schultzberg M., Lundberg J.M., Hökfelt T., Terenius L., Brandt J., Elde R.P., Goldstein M. Enkephalin-like immunoreactivity in gland cells and nerve terminals of the adrenal medulla. Neuroscience. 3:1978;1169-1186.
28. Seltzer Z., Cohn S., Ginzburg R., Berlin B. Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge. Pain. 45:1991;69-75.
29. Siegan J.B., Sagen J. Attenuation of formalin pain responses in the rat by adrenal medullary transplants in the spinal subarachnoid space. Pain. 70:1997;279-285.
30. Stine S.M., Yang H.-Y.T., Costa E. Release of enkephalin-like immunoreactive material from isolated bovine chromaffin cells. Neuropharmacology. 19:1980;683-685.
31. Storkson R.V., Kjorsvik A., Tjolsen A., Hole K. Lumbar catheterization of the spinal subarachnoid space in the rat. J. Neurosci. Methods. 65:1996;167-172.
32. Unsicker K. The trophic cocktail made by adrenal chromaffin cells. Exp. Neurol. 123:1993;167-173.
33. Viveros, O.H., Wilson, S.P. and Chang, K.J., Regulation of synthesis and secretion of enkephalins and related peptides in adrenomedullary chromaffin cells and human pheochromaocytoma. In: E. Costa and M. Trabucchi (Eds.), Regulatory Peptides: From Molecular Biology to Function, Raven Press, New York, 1982, pp. 217-224.
34. Wang H., Sagen J. Absence of appreciable tolerance and morphine cross-tolerance in rats with adrenal medullary transplants in the spinal cord. Neuropharmacology. 33:1994;681-692.
35. Wang H., Sagen J. Attenuation of pain-related hyperventilation in adjuvant arthritic rats with adrenal medullary transplants in the spinal subarachnoid space. Pain. 63:1995;313-320.
36. Wilcox G.L., Carlsson K.-H., Jochim A., Jurna I. Mutual potentiation of antinociceptive effects of morphine and clonidine on motor and sensory responses in rat spinal cord. Brain Res. 405:1987;84-93.
37. Winnie A., Pappas G., Gupta T., Wang H., Ortega J., Sagen J. Subarachnoid adrenal medullary transplants for terminal cancer pain. Anesthesiology. 79:1993;644-653.
38. Xu X.-J., Hao J.-X., Aldskogius H., Seiger Å., Wiesenfeld-Hallin Z. Chronic pain-related syndrome in rats after ischemic spinal cord lesion: a possible animal model for pain in patients with spinal cord injury. Pain. 48:1992;279-290.
39. Xu X.-J., Hao J.-X., Seiger Å., Hughes J., Hökfelt T., Wiesenfeld-Hallin Z. Chronic pain-related behaviors in spinally injured rats: evidence for functional alterations of the endogenous cholecystokinin and opioid systems. Pain. 56:1994;271-277.
40. Yaksh T.L., Reddy S.V. Studies in the primate on the analgetic effects associated with intrathecal action of opiates, alpha-adrenergic agonists and baclofen. Anesthesiology. 54:1981;451-467.
41. Yu, W., Hao, J.-X., Xu, X.-J., Saydoff, J., Haegerstrand, A., Wiesenfeld-Hallin, Z. and Hökfelt, T., Intrathecal bovine chromaffin cells alleviate chronic allodynia-like response in spinally injured rats. Abstr. 8th World Congress on Pain, IASP Press, Seattle, WA, 1996, pp. 379.
42. Yu, W., Hao, J.-X., Xu, X.-J. and Wiesenfeld-Hallin, Z., Comparison of the anti-allodynic and antinociceptive effects of systemic, intrathecal and intracerebroventricular morphine in a rat model of central neuropathic pain, Eur. J. Pain, 1 (1997a) 17-29.
43. Yu, W., Hao, J.-X., Xu, X.-J. and Wiesenfeld-Hallin, Z., The development of morphine tolerance and dependence in rats with chronic pain, Brain Res., 756 (1997b) 141-146.