Co-administration of citalopram and clozapine: Effect on plasma clozapine levels

International Clinical Psychopharmacology

Volumn 13, Issue 1, 1998, Pages 19-21

  Taylor, D ^a   Ellison, Z ^a   Ementon Shaw, L ^a   Wickham, H ^a   Murray, R ^a  

^a SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Citalopram; Clozapine; Cytochromes p4501A2 2D6; Interaction

Indexed keywords

CITALOPRAM; CLOZAPINE; CYTOCHROME P450 ISOENZYME; ISPAGULA; NORCLOZAPINE; VALPROIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; DEPRESSION; DRUG BLOOD LEVEL; DRUG CHOICE; DRUG METABOLISM; HUMAN; PRIORITY JOURNAL; SCHIZOPHRENIA; SENNA; SYMPTOM;

EID: 0031914431     PISSN: 02681315     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004850-199801000-00003     Document Type: Article

References (10)

1. Centorrino F, Baldessarini RJ, Kando J, Frankenburg FR, Volpicelli SA, Puopolo PR, Flood JG (1994). Serum concentrations of clozapine and its major metabolites: effects of co-treatment with fluoxetine or valproate. Am J Psychiatry 151:123-125.
2. Centorrino F, Baldessarini RJ, Frankenburg FR, Kando J, Volpicelli SA, Flood JG (1996). Serum levels of clozapine and norclozapine in patients treated with selective serotonin re-uptake inhibitors. Am J Psychiatry 153:820-822.
3. Dequardo JR, Roberts M (1996). Elevated clozapine levels after fluvoxamine initiation. Am J Psychiatry 153:840-841.
4. Koponen HJ, Leinonen E, Lepola U (1996). Fluvoxamine increases the clozapine serum levels significantly. Eur Neuropsychopharmacol 6:69-71.
5. McCarthy PT, Hughes S, Paton C (1995). Measurement of clozapine and norclozapine in plasma/serum by high performance liquid chromatography and ultraviolet detection. Biomed Chromatogr 9:36-41.
6. Pirmohamed M, Williams D, Madden S, Templeton E, Park BK (1995). Metabolism and bioactivation of clozapine by human liver in vitro. J Pharmacol Exp Ther 272:984-990.
7. Taylor D (1995). Selective serotonin reuptake inhibitors and tricyclic antidepressants in combination - interactions and therapeutic uses Br J Psychiatry 167:575-580.
8. Taylor D, Duncan D (1995). The use of clozapine plasma levels in optimising therapy. Psychiatr Bull 19:753-55.
9. Taylor D, Lader M (1996). Editorial - cytochromes and psychotropic drug interactions. Br J Psychiatry 168:529-532.
10. Tyson SC, Devane CL, Risch SC (1995). Clozapine interaction. Increased plasma concentrations with concomitant risperidone: case report. Am J Psychiatry 152:1401-1402.