Effects of dienogest, a synthetic steroid, on experimental endometriosis in rats

European Journal of Endocrinology

Volumn 138, Issue 2, 1998, Pages 216-226

  Katsuki, Yukio ^b   Takano, Yukiko ^b   Futamura, Yoshihiro ^b   Shibutani, Yasunori ^b   Aoki, Daisuke ^a   Udagawa, Yasuhiro ^a   Nozawa, Shiro ^a  

^a KEIO UNIVERSITY   (Japan)

^b MOCHIDA PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUSERELIN; DANAZOL; DIENOGEST; MIFEPRISTONE; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOTRANSPLANTATION; BONE DENSITY; BONE MINERAL; CELL PROLIFERATION; CONTROLLED STUDY; ENDOMETRIOSIS; ENZYME ACTIVITY; LIPID METABOLISM; NONHUMAN; OVARIECTOMY; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RAT; SPLEEN CELL; WEIGHT GAIN;

ANIMALS; BUSERELIN; CELL DIVISION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOTOXICITY, IMMUNOLOGIC; DANAZOL; DISEASE MODELS, ANIMAL; ENDOMETRIOSIS; ENZYME INHIBITORS; ESTRADIOL; FEMALE; IMMUNITY, CELLULAR; INTERLEUKIN-1; KILLER CELLS, NATURAL; MACROPHAGES, PERITONEAL; NANDROLONE; PROGESTERONE; PROGESTERONE CONGENERS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031913441     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1380216     Document Type: Article

References (32)

1. Shaw RW. Treatment of endometriosis. Lancet 1992 340 1267-1270.
2. Forbes KL & Thomas FJ. Tissue and endocrine responses to gestrinone and danazol in the treatment of endometriosis. Reproduction, Fertility and Development 1993 5 103-109.
3. Fedele L, Bianchi S, Arcaini L, Vercellini P & Candiani GB. GnRH agonists in the treatment of endometriosis. Acta Europaea Fertilitatis 1988 19 5-12.
4. Metzger DA & Luciano AA. Hormonal therapy of endometriosis. Obstetrics and Gynecology Clinics of North America 1989 16 105-122.
5. Barbieri RL & Ryan KJ. Danazol: Endocrine pharmacology and therapeutic application. American Journal of Obstetrics and Gynecology 1981 141 453-463.
6. Moghissi AS. Treatment of endometriosis with estrogen-progestin combination and progestogens alone. Clinical Obstetrics and Gynecology 1988 31 823-828.
7. Henzl MR. Gonadotropin-releasing hormone (GnRH) agonists in the management of endometriosis: A review. Clinical Obstetrics and Gynecology 1988 31 840-856.
8. Katsuki Y, Sasagawa S, Takano Y, Shibutani Y, Aoki D, Udagawa Y et al. Animal studies on the endocrinological profile of dienogest, a novel synthetic steroid. Drugs under Experimental and Clinical Research 1997 23 45-62.
9. Sakata M, Terakawa N, Mizutani T, Tanizawa O, Matsumoto K, Terada N et al. Effects of danazol, gonadotropin-releasing hormone agonist, and a combination of danazol and gonadotropin-releasing hormone agonist on experimental endometriosis. American Journal of Obstetrics and Gynecology 1990 163 1679-1684.
10. Sato M. Comparative x-ray densitometry of bones from ovariectomized rats. Bone 1995 17 (Suppl) 157-162.
11. Blomberg K, Granberg C, Hemmilä I & Lövgren T. Europium-labelled target cells in an assay of natural killer cell activity. I. A novel non-radioactive method based on time-resolved fluorescence. Journal of Immunological Methods 1986 86 225-229.
12. Carter GW, Young PR, Martin MK & Mollison KW. Measurement of inflammatory reactions by a dye dilution method. Journal of Pharmacy and Pharmacology 1982 34 66-67.
13. Kukita T, Kukita A, Hata K & Kurisu K. 12-O-tetradecanoylphorbol-13-acetate inhibits osteoclast-like cell differentiation in rat bone marrow cultures inducing macrophage polykaryons. Endocrinology 1992 130 577-584.
14. Hemmilä I. Lanthanides as probes for time-resolved fluorometric immunoassays. Scandinavian Journal of Clinical and Laboratory Investigation 1988 48 389-400.
15. Sharpe KL, Zimmer RL, Khan RS & Penney LL. Proliferative and morphogenic changes induced by the coculture of rat uterine and peritoneal cells: a cell culture model for endometriosis. Fertility and Sterility 1992 58 1220-1229.
16. Alfthan H. Comparison of immunoradiometric and immunofluorometric assays for serum hCG. Journal of Immunological Methods 1986 88 239-244.
17. Sasaki T, Kawai K, Saijo-Kurita K & Ohno T. Detergent cytotoxicity: Simplified assay of cytolysis by measuring LDH activity. Toxicology In Vitro 1992 6 451-457.
18. Lundin A, Rickardsson A & Thore A. Continuous monitoring of ATP-converting reactions by purified firefly luciferase. Analytical Biochemistry 1976 75 611-620.
19. Yano T, Taura C, Shibata M, Hirono Y, Ando S, Kusubata M et al. A monoclonal antibody to the phosphorylated form of glial fibrillary acidic protein: Application to a nonradioactive method for measuring protein kinase activities. Biochemical and Biophysical Research Communications 1991 175 1144-1151.
20. Vernon MW & Wilson EA. Studies on the surgical induction of endometriosis in the rat. Fertility and Sterility 1985 44 684-694.
21. Wright JA & Sharpe-Timms KL. Gonadotropin-releasing hormone agonist therapy reduces postoperative adhesion formation and reformation after adhesiolysis in rat models for adhesion formation and endometriosis. Fertility and Sterility 1995 63 1094-1100.
22. Sakura Y, Masaki T, Sudo K, Nomura M & Shino A. Histological studies on the therapeutic effect of sustained release microspheres of a potent LHRH agonist (Leuprorelin acetate) in an experimental endometriosis model in rats. Endocrinologia Japonica 1990 37 719-729.
23. Conference Report. Consensus development conference: prophylaxis and treatment of osteoporosis. British Medical Journal 1987 295 914-915.
24. Ylikorkala O, Nilsson CG, Hirvonen E & Viinikka L. Evidence of similar increase in bone turnover during nafarelin and danazol use in women with endometriosis. Gynecology and Endocrinology 1990 4 251-260.
25. Kauppila A. Changing concepts of medical treatment of endometriosis. Acta Obstetrica et Gynecologica Scandinavica 1993 72 324-336.
26. Halme J, Becker S & Haskill S. Altered maturation and function of peritoneal macrophages: possible role in pathogenesis of endometriosis. American Journal of Obstetrics and Gynecology 1987 156 783-789.
27. Eisermann J, Gast MG, Pineda J, Odem RR & Collins JL. Tumor necrosis factor in peritoneal fluid of women undergoing laparoscopic surgery. Fertility and Sterility 1988 50 573-579.
28. Taketani Y, Kuo TM & Mizuno M. Comparison of cytokine levels and embryo toxicity in peritoneal fluid in infertile women with untreated or treated endometriosis. American Journal of Obstetrics and Gynecology 1992 167 265-270.
29. Uda S & Umesaki N. The role of peritoneal macrophage in infertility associated with endometriosis: animal experiment. Acta Obstetrica et Gynecologica Japonica 1991 43 497-502.
30. Oosterlynck DJ, Vandeputte M, Cornillie FJ, Koninckx PR & Waer M. Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium. Fertility and Sterility 1991 56 45-51.
31. Ishikawa N. Changes in natural killer (NK) activity and fertility during the establishment of experimental endometriosis in the rat. Acta Obstetrica et Gynecologica Japonica 1995 47 457-464.
32. Oosterlynck DJ, Meuleman C, Waer M, Vandeputte M & Koninckx PR. The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis. Fertility and Sterility 1992 58 290-295.