Immunological and molecular analysis of three monoclonal lupus anticoagulant antibodies from a patient with systemic lupus erythematosus

Journal of Autoimmunity

Volumn 11, Issue 1, 1998, Pages 39-51

  Lai, Chung Jeng ^a   Rauch, Joyce ^b   Cho, Chul Soo ^a   Zhao, Van ^a   Chukwuocha, Reginald U ^a   Chen, Pojen P ^a,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MONTREAL GENERAL HOSPITAL   (Canada)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anti cardiolipin antibody; Anti phospholipid antibody; Antiphospholipid syndrome (APS); Human lupus anticoagulant (LAC)

Indexed keywords

AUTOANTIBODY; CARDIOLIPIN; CARDIOLIPIN ANTIBODY; HUMAN MONOCLONAL ANTIBODY; LUPUS ANTICOAGULANT; PHOSPHOLIPID; PHOSPHOLIPID ANTIBODY;

ADULT; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CASE REPORT; FEMALE; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0031913317     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1997.0174     Document Type: Article

References (68)

1. Harris E.N., Gharavi A.E., Boey M.L., Patel B.M., Mackworth-Young C.G., Loizou S., Hughes G.R. 1983. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 2: 1211-1214
2. Harris E.N., Gharavi A.E., Hughes G.R.V. 1985. Anti-phospholipid antibodies. Clin. Rheum. Dis. 11: 591-609
3. McNeil H.P., Chesterman C.N., Krilis S.A. 1991. Immunology and clinical importance of antiphospholipid antibodies. Adv. Immunol. 49: 193-280
4. Asherson R.A., Cervera R. 1993. Anticardiolipin antibodies, chronic biologic false-positive tests for syphilis and other antiphospholipid antibodies. In Dubais' Lupus Erythematosus. D.J. Wallace, B.H. Hahn, eds. Lea & Febiger, Philadelphia, pp. 233-244
5. Bevers E.M., Galli M., Barui T., Comfurius P., Zwaal R.F.A. 1991. Lupus anticoagulant IgGs (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin. Thromb. Haemost. 66: 629-632
6. Brandt J.T., Triplett D.A., Alving B., Scharrer I. 1995. Criteria for the diagnosis of lupus anticoagulants: an update. Thromb. Haemost. 74: 1185-1190
7. McNeil H.P., Simpson R.J., Chesterman C.N., Krilis S.A. 1990. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). Proc. Natl. Acad. Sci. USA 87: 4120-4124
8. Matsuura E., Igarashi Y., Fujimoto M., Ichikawa K. 1990. Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet 336: 177-178
9. Galli M., Comfurius P., Maassen C., Hemker H.C., de Baets M.H., van Breda-Vriesman P.J.C., Barbui T., Zwaal R.F.A., Bevers E.M. 1990. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 335: 1544-1547
10. Viard J.P., Amoura Z., Bach J.F. 1992. Association of anti-beta 2 glycoprotein I antibodies with lupus-type circulating anticoagulant and thrombosis in systemic lupus erythematosus. Am. J. Med. 93: 181-186
11. 2-glycoprotein I contains a phospholipid binding site (Cys281-Cys288) and a region recognized by anticardiolipin antibodies. J. Immunol. 152: 653-659
12. 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J. Exp. Med. 179: 457-462
13. 2-glycoprotein I reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome. Arthritis Rheum. 37: 1453-1461
14. 2-glycoprotein I in the absence of phospholipid: importance of Ag density and bivalent binding. J. Immunol. 154: 954-960
15. 2-glycoprotein I is bound to a suitable surface. Thromb. Haemost. 73: 29-34
16. Exner T., Sahman N., Trudinger B. 1988. Separation of anticardiolipin antibodies from lupus anticoagulant on a phospholipid-coated polystyrene column. Biochem. Biophys. Res. Commun. 155: 1001-1007
17. McNeil H.P., Chesterman C.N., Krilis S.A. 1989. Anticardiolipin antibodies and lupus anticoagulants comprise separate antibody subgroups with different phospholipid binding characteristics. Br. J. Haematol. 73: 506-513
18. 2-glycoprotein I is a requirement for anticardiolipin antibodies binding to activated platelets: differences with lupus anticoagulants. Blood 81: 1255-1262
19. Pierangeli S.S., Harris E.N., Gharavi A.E., Goldsmith G., Branch D.W., Dean W.L. 1993. Are immunoglobulins with lupus anticoagulant activity specific for phospholipids? Br. J. Haematol. 85: 124-132
20. Pengo V., Biasiolo A. 1993. Purification of anticardiolipin and lupus anticoagulant activities by using cardiolipin immobilized on agarose beads. Thromb. Res. 72: 423-430
21. Tiagarajan P., Shapiro S.S., De Marco L. 1980. Monoclonal immunoglobulin Mλ coagulation inhibitor with phospholipid specificity; mechanism of a lupus anticoagulant. J. Clin. Invest. 66: 397-405
22. Hasegawa I., Suzuki T., Ishii S., Takakuwa K., Tanaka K. 1994. Establishment of two distinct anti-cardiolipin antibody-producing cell lines from the same individual by Epstein-Barr virus transformation. Thromb. Res. 74: 77-84
23. Ravirajan C.T., Harmer I., McNally T., Hohmann A., Mackworth-Young C.G., Isenberg D.A. 1995. Phospholipid binding specificities and idiotype expression of hybridoma derived monoclonal autoantibodies from splenic cells of patients with systemic lupus erythematosus. Ann. Rheum. Dis. 54: 471-476
24. Menon S., Rahman M.A.A., Ravirajan C.T., Kandiah D., Longhurst C.M., McNally T., Williams W.M., Latchman D.S., Isenberg D.A. 1997. The production, binding characteristics and sequence analysis of four human IgG monoclonal antiphospholipid antibodies. J. Autoimmun. 10: 43-57
25. 2-glycoprotein I is potentiated by a distinct subgroup of anticardiolipin antibodies. Thromb. Haemost. 68: 297-300
26. 2-glycoprotein I. J. Clin. Invest. 90: 1100-1104
27. Massicotte H., Rauch J., Shoenfeld Y., Tannenbaum H. 1984. Delineation of optimal conditions for the protection of human-human hybridomas secreting anti-DNA autoantibodies from patients with systemic lupus erythematosus. Hybridoma 3: 215-222
28. Tan E.M., Cohen A.S., Fries J.F., Masi A.T., McShane D.J., Rothfield N.F., Schaller J.G., Talal N., Winchester R.J. 1982. The 1982 revised criteria for the classification of SLE. Arthritis Rheum. 25: 1271-1277
29. Rauch J., Tannenbaum M., Tannenbaum H., Ramelson H., Cullis P.R., Tilcock C.P.S., Hope M.J., Janoff A.S. 1986. Human hybridoma lupus anticoagulants distinguish between lamellar and hexagonal phase lipid systems. J. Biol. Chem. 261: 9672-9678
30. Rauch J., Tannenbaum M., Janoff A.S. 1989. Distinguishing plasma lupus anticoagulants from anti-factor antibodies using hexagonal (II) phase phospholipids. Thromb. Haemost. 62: 892-896
31. Meng Q.-H., Rauch J. 1990. Differences between human hybridoma platelet-binding antibodies derived from systemic lupus erythematosus patients and normal individuals. Autoimmunity 5: 151-167
32. Rauch J., Massicotte H., Tannenbaum H. 1985. Hybridoma anti-DNA autoantibodies from patients with rheumatoid arthritis and systemic lupus erythematosus display similar nucleic acid binding characteristics. J. Immunol. 134: 180-186
33. 3H motifs. Mol. Immunol. 32: 683-696
34. Rauch J., Meng Q.-H., Tannenbaum H. 1987. Lupus anticoagulant and antiplatelet properties of human hybridoma autoantibodies. J. Immunol. 139: 2598-2604
35. Olee T., Lu E.W., Huang D.-F., Soto-Gil R.W., Deftos M., Kozin F., Carson D.A., Chen P.P. 1992. Genetic analysis of self-associating IgG rheumatoid factors from two rheumatoid synovia implicates an antigen driven response. J. Exp. Med. 175: 831-842
36. Huang D.-F., Olee T., Masuho Y., Matsumoto Y., Carson D.A., Chen P.P. 1992. Sequence analyses of three IgG anti-virus antibodies reveal their utilization of autoantibody-related Ig Vh genes, but not Vλ genes. J. Clin. Invest. 90: 2197-2208
37. Devereux J., Haeberli P., Smithies O. 1984. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12: 387-395
38. Chen P.P., Liu M.-F., Sinha S., Carson D.A. 1988. A 16/6 idiotype positive anti-DNA antibody is encoded by a conserved Vh gene with no somatic mutation. Arthritis Rheum. 31: 1429-1431
39. Chen P.P. 1990. Structural analyses of human developmentally regulated Vh3 genes. Scand. J. Immunol. 31: 257-267
40. u gene and identification of a new DH locus. EMBO J. 7: 2003-2010
41. Pascual V., Capra J.D. 1991. Human immunoglobulin heavy-chain variable region genes: organization, polymorphism, and expression. Adv. Immunol. 49: 1-74
42. Ellison J., Hood L. 1982. Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes. Proc. Natl. Acad. Sci. USA 79: 1984-1988
43. Hieter P.A., Maizel J.V. Jr., Leder P. 1982. Evolution of human immunoglobulin K J region genes. J. Biol. Chem. 257: 1516-1522
44. lambda gene segments. Eur. J. Immunol. 23: 1456-1461
45. Udey J.A., Blomberg B. 1987. Human lambda light chain locus: organization and DNA sequences of three genomic J regions. Immunogenetics 25: 63-70
46. Berman J.E., Mellis S.J., Pollock R., Smith C.L., Suh H., Heinke B., Kowal C., Surti U., Chess L., Cantor C.R., Alt F.W. 1988. Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus. EMBO J. 7: 727-738
47. Lautner-Rieske A., Huber C., Meindl A., Pargent W., Schable K.F., Thiebe R., Zocher I., Zachau H.G. 1992. The human immunoglobulin K locus. Characterization of the duplicated A regions. Eur. J. Immunol. 22: 1023-1029
48. Fleck R.A., Rapaport S.I., Rao L.V. 1988. Anti-prothrombin antibodies and the lupus anticoagulant. Blood 72: 512-519
49. 2-glycoprotein I in the expression of lupus anticoagulant activity. Blood 83: 2878-2892
50. Sanz I., Dang H., Takei M., Talal N., Capra J.D. 1989. V-H sequence of a human anti-Sm autoantibody. J. Immunol. 142: 883-887
51. Dersimonian H., Schwartz R.S., Barrett K.J., Stollar B.D. 1987. Relationship of human variable region heavy chain germ-line genes to genes encoding anti-DNA autoantibodies. J. Immunol 139: 2496-2501
52. H4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus. J. Autoimmun. 6: 809-825
53. Gay D., Saunders T., Camper S., Weigert M. 1993. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177: 999-1008
54. Chen C., Radic M.Z., Erikson J., Camper S.A., Litwin S., Hardy R.R., Weigert M. 1994. Deletion and editing of B cells that express antibodies to DNA. J. Immunol. 152: 1970-1982
55. Suzuki N., Harada T., Mihara S., Sakane T. 1996. Characterization of a germline Vk gene encoding cationic anti-DNA antibody and role of receptor editing for development of the autoantibody in patients with systemic lupus erythematosus. J. Clin. Invest. 98: 1843-1850
56. Harmer I.J., Loizou S., Thompson K.M., So A.K.L., Walport M.J., Mackworth-Young C. 1995. A human monoclonal antiphospholipid antibody that is representative of serum antibodies and is germline encoded. Arthritis Rheum. 38: 1068-1076
57. Harris E.N., Gharavi A.E., Tincani A., Chan J.K., Englert H., Mantelli P., Allegro F., Ballestrieri G., Hughes G.R. 1985. Affinity purified anti-cardiolipin and anti-DNA antibodies. J. Clin. Lab. Immunol. 17: 155-162
58. Eilat D., Zlotnick A.Y., Fischel R. 1986. Evaluation of the crossreaction between anti-DNA and anticardiolipin antibodies in SLE and experimental animals. Clin. Exp. Immunol. 65: 269-275
59. Smeenk P.J.T., Luccassen W.A.M., Swaak T.J.G. 1987. Is anticardiolipin activity a crossreaction of anti-DNA or a separate entity? Arthritis Rheum. 30: 607-613
60. Sammaritano L.R., Lockshin M.D., Gharavi A.E. 1992. Antiphospholipid antibodies differ in aPL cofactor requirement. Lupus 1: 83-90
61. Olee T., Yang P.-M., Siminovitch K.A., Olsen N.J., Hillson J., Wu J., Kozin F., Carson D.A., Chen P.P. 1991. Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases. J. Clin. Invest. 88: 193-203
62. Combriato G., Klobeck H.-G. 1991. Vλ and Jλ-Cλ gene segments of the human immunoglobulin λ light chain locus are separated by 14 kb and rearrange by a deletion mechanism. Eur. J. Immunol. 21: 1513-1522
63. Pargent W., Meindl A., Thiebe R., Mitzel S., Zachau H.G. 1991. The human immunoglobulin K locus. Characterization of the duplication O regions. Eur. J. Immunol. 21: 1821-1827
64. Hieter P.A., Max E.E., Seidman J.G., Maizel J.V. Jr., Leder P. 1980. Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. Cell 22: 197-207
65. Ichihara Y., Matsuoka H., Kurosawa Y. 1988. Organization of human immunoglobulin heavy chain diversity gene loci. EMBO J. 7: 4141-4150
66. Silberstein L.E., Jefferies L.C., Goldman J., Friedman D., Moore J.S., Nowell P.C., Roelcke D., Pruzanski W., Roudier J., Silverman G.J. 1992. Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens. Blood 78: 2372-2386
67. Dersimonian H., McAdam K.P.W.J., Mackworth-Young C., Stollar B.D. 1989. The recurrent expression of variable region segments in human IgM anti-DNA autoantibodies. J. Immunol. 142: 4027-4033
68. Paul E., Iliev A.A., Livneh A., Diamond B. 1992. The anti-DNA-associated idiotype 8.12 is encoded by the VlambdaII gene family and maps to the vicinity of L chain CDR1. J. Immunol. 149: 3588-3595