Chronic treatment of female rhesus monkeys with low doses of the antiprogestin ZK 137 316: Establishment of a regimen that permits normal menstrual cyclicity

Human Reproduction

Volumn 13, Issue 2, 1998, Pages 259-267

  Zelinski Wooten, M B ^a   Slayden, O D ^a   Chwalisz, K ^c   Hess, D L ^a   Brenner, R M ^a   Stouffer, R L ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c BAYER PHARMA AG   (Germany)

Author keywords

Antiprogestin; Menstrual cycle; Ovary; Steroids; ZK 137 316

Indexed keywords

ANTIGESTAGEN; CONTRACEPTIVE AGENT; ESTRADIOL; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; PROGESTERONE; UNCLASSIFIED DRUG; ZK 137316;

AMENORRHEA; ANIMAL EXPERIMENT; ANOVULATION; ARTICLE; CONTROLLED STUDY; CORPUS LUTEUM; DOSE RESPONSE; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; GONADOTROPIN RELEASE; HYPOPHYSIS FUNCTION; INTRAMUSCULAR DRUG ADMINISTRATION; LUTEAL PHASE; LUTEINIZING HORMONE BLOOD LEVEL; MENSTRUAL CYCLE; MENSTRUATION; NONHUMAN; OVARY FOLLICLE DEVELOPMENT; PROGESTERONE BLOOD LEVEL; PROGESTERONE RELEASE; RHESUS MONKEY;

ANIMALIA; MACACA; MACACA MULATTA;

EID: 0031913282     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/13.2.259     Document Type: Article

References (35)

1. Batista, M.C., Bristow, T.L., Mathews, J. et al. (1991) Daily administration of the progesterone antagonist RU 486 prevents implantation in the cycling guinea pig. Am. J. Obstet. Gynecol., 165, 82-86.
2. Batista, M.C., Cartledge, T.P, Zellmer, A.W. et al. (1992) Delayed endometrial maturation induced by daily administration of the antiprogestin RU 486: a potential new contraceptive strategy. Am. J. Obstet. Gynecol., 167, 60-65.
3. Cameron, S.T., Thong, K.J. and Baird, D.T. (1995) Effect of daily low dose mifepristone on the ovarian cycle and on dynamics of follicle growth. Clin. Endocrinol., 43, 407-414.
4. Cameron, ST., Critchley, H.O.D., Thong, K.J. et al. (1996) Effects of daily low dose mifepristone on endometrial maturation and proliferation. Hum, Reprod., 11, 2518-2526.
5. Chwalisz, K., Gemperlein, I., Puri, C.P. et al. (1997) Endometrial contraception with progesterone antagonists: an experimental approach. In Beier, H.M., Harper, M.J.K. and Chwalisz, K. (eds), Ernst Schering Research Foundation Workshop 18. Springer-Verlag, Berlin, Germany, pp. 223-259.
6. Couzinet, B., LeStrat, N., Silvestre, L. et al. (1990) Late luteal phase administration of the antiprogesterone RU486 in normal women: effects on the menstrual cycle events and fertility control in a long-term study. Fertil. Steril., 54, 1039-1044.
7. Croxatto, H.B., Salvatierra, A.M., Croxatto, H.D. et al. (1993) Effects of continuous treatment with low dose mifepristone throughout one menstrual cycle. Hum. Reprod., 8, 201-207.
8. Croxatto, H.B., Fuentealba, G., Salvatierra, A.M. et al. (1997) Clinical strategies for the achievement of endometrial contraception with progesterone antagonists. In Beier, H.M., Harper, M.J.K. and Chwalisz, K. (eds), The Endometrium as a Target for Contraception. Springer-Verlag, Berlin, Germany, pp. 259-278.
9. Danforth, D.R., Dubois, C., Ulmann, A. et al. (1989) Contraceptive potential of RU 486 by ovulation inhibition. III. Preliminary observations on once weekly oral administration. Contraception, 40, 195-200.
10. Ellinwood, W.E., Norman, R.L. and Spies, H.G. (1984) Changing frequency of pulsatile luteinizing hormone and progesterone secretion during the luteal phase of the menstrual cycle of rhesus monkeys. Biol. Reprod., 31, 714-722.
11. Gemzell-Danielsson, K., Westlund, P., Johannisson, E. et al. (1996) Effect of low weekly doses of mifepristone on ovarian function and endometrial development. Hum. Reprod., 11, 256-264.
12. Gemzell-Danielsson, K., Swahn, M.-L., Westlund, P. et al. (1997) Effect of low daily doses of mifepristone on ovarian function and endometrial development. Hum. Reprod., 12, 124-131.
13. Ghosh, D., Sengupta, J. and Hendrickx, A.G. (1996) Effect of a single-dose, early luteal phase administration of mifepristone (RU486) on implantation stage endometrium in the rhesus monkey. Hum. Reprod., 11, 2026-2035.
14. Ghosh, D., Luther, P.O., Kumar, L. et al. (1997) Early luteal phase administration of mifepristone inhibits preimplantation embryo development and viability in the rhesus monkey. Hum. Reprod., 12, 575-582.
15. Hibbert, M.L., Stouffer, R.L., Wolf, D.P. et al. (1996) Midcycle administration of a progesterone synthesis inhibitor prevents ovulation in primates. Proc. Natl. Acad. Sci. USA, 93, 1897-1901.
16. Illingworth, P.J., Groome, N.P, Duncan, W.C. et al. (1996) Measurement of circulating inhibin forms during the establishment of pregnancy. J. Clin. Endocrinol. Metab., 81, 1471-1475.
17. Ishwad, P.C., Katkam, R.R., Hinduja, I.N. et al. (1993) Treatment with a progesterone antagonist ZK 98.299 delays endometrial development without blocking ovulation in bonnet monkeys. Contraception, 48, 57-70.
18. Katkam, R.R., Gopalkrishnan, K., Chwalisz, K. et al. (1995) Onapristone (ZK 98.299): a potential antiprogestin for endometrial contraception. Am. J. Obstet. Gynecol., 173, 779-787.
19. Kettel, L.M., Greene, K. and Yen, S.S.C. (1992) Endometrial dyssynchronization without hormonal changes by the antiprogestin RU486 during the luteal phase of the menstrual cycle: a contraceptive potential. In Society for Gynecological Investigation Program and Abstracts, 39th Annual Meeting, p. 152, Abstr. 88.
20. Lebeau, M.-C. and Baulieu, E.E. (1994) Steroid antagonists and receptor-associated proteins. Hum. Reprod., 9 (Suppl. 1), 11-21.
21. Ledger, W.L., Sweeting, V.M., Millier, H. et al. (1992) Inhibition of ovulation by low-dose mifepristone (RU 486). Hum. Reprod., 7, 945-950.
22. Murphy, A.A., Kettel, L.M., Morales, A.J. et al. (1995) Endometrial effects of long-term low-dose administration of RU486. Fertil. Steril., 63, 761-766.
23. Puri, C.P. and Van Look, P.F.A. (1991) Newly developed competitive progesterone antagonists for fertility control. In Agarwal, M.K. (ed.), Antihormones in Health and Disease. Karger, Basel, Switzerland, pp. 127-167.
24. Resko, J.A., Norman, R.L., Niswender, G.D. et al. (1974) The relationship between progestins and gonadotropins during the late luteal phase of the menstrual cycle in rhesus monkeys. Endocrinology, 97, 128-135.
25. Resko, J.A., Ploem, J.G. and Stadelman, H.L. (1975) Estrogens in fetal and maternal plasma of the rhesus monkey. Endocrinology, 97, 425-430.
26. Roblero, L.S. and Croxatto, H.B. (1991) Effect of RU486 on development and implantation of rat embryos. Mol. Reprod. Dev., 29, 342-356.
27. Slayden, O.D. and Brenner, R.M. (1994) RU486 action after estrogen-priming in the endometrium and oviducts of rhesus monkeys (Macaca mulatto). J. Clin. Endocrinol. Metab., 78, 440-448.
28. Slayden, O.D., Hirst, J.J. and Brenner, R.M. (1993) Estrogen action in the reproductive tract during antiprogestin treatment. Endocrinology, 132, 1845-1856.
29. Slayden, O.D., Zelinski-Wooten, M.B., Chwalisz, K. et al. (1998) Chronic treatment of cycling rhesus monkeys with low doses of the antiprogestin ZK 137 316: morphometric assessment of the uterus and oviduct. Hum. Reprod., 13, 269-277.
30. Spitz, I.M., Croxatto, H.B. and Robbins, A. (1996) Antiprogestins: mechanism of action and contraceptive potential. Annu. Rev. Pharmacol. Toxicol, 36, 47-81.
31. Van Look, P.F.A. and von Hertzen, H. (1994) Post-ovulatory methods of fertility regulation: the emergence of antiprogestins. In Van Look, P.F.A. and Perez-Palacios, G. (eds), Contraceptive Research and Development: the Road from Mexico City to Cairo and Beyond. Oxford University Press, Delhi, India, pp. 151-201.
32. Van Look, P.F.A. and von Hertzen, H. (1995) Clinical uses of antiprogestogens. Hum. Reprod. Update, 1, 19-34.
33. van Uem, J.F.H.M., Hsiu, J.G., Chillik, C.F. et al. (1989) Contraceptive potential of RU 486 by ovulation inhibition. I. Pituitary versus ovarian action with blockade of estrogen-induced endometrial proliferation. Contraception, 40, 171-184.
34. Vinijsanun, A. and Martin, L. (1990) Effects of progesterone antagonists RU486 and ZK98734 on embryo transport, development and implantation in laboratory mice. Reprod. Fertil. Dev., 2, 713-727.
35. Wolf, J.P., Hsiu, J.G., Anderson, T.L. et al. (1989) Noncompetitive anti-estrogenic effect of RU486 in blocking the estrogen-stimulated luteinizing hormone surge and the proliferative action of estradiol on endometrium in castrate monkeys. Fertil. Steril., 52, 1055-1060.