Cell-specific differences in the susceptibility of potential cellular targets of human origin derived from blood and lung following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Cell Biology and Toxicology

Volumn 14, Issue 1, 1998, Pages 23-38

  Lang, D S ^a,c   Becker, S ^b   Devlin, R B ^b   Koren, H S ^b  

^a University of N Carolina   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; Cytochrome P4501A (CYP1A1) induction; Cytokines; Human lung cells; In vitro; Peripheral blood cells

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; BIOCHEMICAL MARKER; CYTOCHROME P450; MESSENGER RNA;

ARTICLE; BLOOD CELL; CELL CULTURE; CELL TYPE; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; LYMPHOCYTE; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL;

ADOLESCENT; ADULT; BRONCHI; CYTOCHROME P-450 CYP1A1; CYTOKINES; EPITHELIAL CELLS; HUMANS; LYMPHOCYTES; MACROPHAGES, ALVEOLAR; MONOCYTES; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN;

EID: 0031913154     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007412404180     Document Type: Article

References (56)

1. Akira S, Hirano T, Taga T, Kishimoto T. Biology of multi-functional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J. 1990;4:2860-7.
2. Antilla S, Hirvonen A, Husgafvel-Pursiainen K, Karjalainen A, Nurminen T, Vainio H. Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer. Carcinogenesis. 1994;15:1133-5.
3. Becker S, Koren HS, Henke DC. Interleukin-8 expression in normal nasal epithelium and its modulation by infection with respiratory syncytial virus and cytokines tumor necrosis factor, interleukin-1, and interleukin-6. Am J Respir Cell Mol Biol. 1993;8:20-7.
4. Becker S, Quay J, Soukup J. Cytokine (tumor necrosis factor, IL-6, and IL-8) production by respiratory syncytial virusinfected human alveolar macrophages. J Immunol. 1991; 147:4307-12.
5. Clark G, Tritscher A, Bell D, Lucier G. Integrated approach for evaluating species and interindividual differences in responsiveness to dioxins and structural analogs. Environ Health Perspect. 1992;98:125-32.
6. Clark GC, Taylor MJ, Tritscher AM, Lucier GW. Tumor necrosis factor involvement in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated endotoxin hypersensitivity in C57BL/6J mice congenic at the Ah locus. Toxicol Appl Pharmacol. 1991;111:422-31.
7. Conney AH. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons. Cancer Res. 1982;42:4857-917.
8. Dimitriu-Bona A, Burmester GR, Waters SJ, Winchester RJ. Human mononuclear phagocyte differentiation antigens. I. Patterns of antigenic expression on the surface of human monocytes and macrophages defined by monoclonal antibodies. J Immunol. 1983;130:145-52.
9. Fingerhut MA, Halperin WE, Marlow DA et al. Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. N Engl J Med. 1991;324:212-8.
10. Gaido KW, Leonard LS, Maness SC, Andersen ME. TCDD-induced relation of gene expression in human keratinocytes. CIIT Activities. 1991;11:1-7.
11. Hamilton JA. Review. Colony stimulating factors, cytokines and monocyte-macrophages - some controversies. Immunol Today. 1993;14:18-24.
12. Hirano T, Yasukawa K, Harada H et al. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature. 1996;324:73.
13. House RV, Lauer LD, Murray MJ et al. Examination of immune parameters and host resistance mechanisms in B6C3F1 mice following adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Toxicol Environ Health. 1990; 31:203-15.
14. Huff J, Lucier G, Tritscher A. Carcinogenicity of TCDD: Experimental, mechanistic, and epidemiologic evidence. Annu Rev Toxicol. 1994;34:343-72.
15. Jaiswal A, Gonzalez FJ, Nebert DW Human P1-450 gene differences in benzo(a)pyrene metabolism. Nucleic Acids Res. 1985;13:4503-19.
16. Johnson ES. Human exposure to 2,3,7,8-TCDD and risk of cancer. Crit Rev Toxicol. 1992;21:451-63.
17. Kawajiri K, Nakachi K, Imai K, Yoshii A, Shinoda N, Watanabe J. Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P4501A1 gene. FEBS Lett. 1990;263:131-3.
18. Kawajiri K, Nakachi K, Imai K, Watanabe J, Hayashi S. The CTP1A1 gene and cancer susceptibility. Crit Rev Oncol/ Haematol. 1993;14:77-87.
19. Kellermann G, Cantrell E, Shaw CR. Variations in extent of aryl hydrocarbon hydroxylase induction in cultured human lymphocytes. Cancer Res. 1973;33:1654-6.
20. Kerkvliet NI, Beacher-Steppan L, Shepherd DM, Oughton JA, Vorderstrasse BA, DeKrey GK. Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Immunol. 1996;157:2301-9.
21. Koren HS, Devlin RB, Graham DE et al. Ozone induced inflammation in the lower airways of human subjects. Am Rev Respir Dis. 1989;139:415.
22. Kouri RE, Ratrie H, Atlas SA, Niwa A, Nebert DW. Aryl hydroxylase induction in human lymphocyte cultures by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Life Sci. 1974; 15: 1585-95.
23. Lacy SA, Mangum JB, Everitt JI. Cytochrome P-450- and glutathione-associated enzyme activities in freshly isolated enriched lung cell fractions from β-naphthoflavone-treated male F344 rats. Toxicology. 1992;73:147-60.
24. Lang DS, Becker S, Clark GC, Devlin RB, Koren HS. Lack of direct immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on human peripheral blood lymphocyte subsets in vitro. Arch Toxicol. 1994;68:296-302.
25. Lin F, Clark G, Birnbaum L, Lucier G, Goldstein J. The influence of the Ah locus on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hepatic growth factor receptor. Mol Pharmacol. 1991;39:307-13.
26. Lorenzen A, Okey AB. Detection and characterization of Ah receptor in tissue and cells from human tonsils. Toxicol Appl Pharmacol. 1991;107:203-14.
27. Lorr NA, Sinclair JF, Sinclair PR, Bloom SE. Detection and localization of 3,3,4,4-tetrachlorobiphenyl-induced P4501A protein in avian primary immune tissues. Int J Immunopharmacol. 1994;16:875-85.
28. Lucier GW Humans are a sensitive species to some of the biochemical effects of structural analogs of dioxin. Environ Toxicol Chem. 1991;10:727-35.
29. Mantovani A, Vecchi A, Luini W et al. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on macrophage and natural killer cell mediated cytotoxicity in mice. Biomedicine. 1980;32:200-4.
30. Manz A, Berger J, Dwyer JH, Flesch-Janys D, Nagel S, Waltsgott H. Cancer mortality among workers in chemical plant contaminated with dioxin. Lancet. 1991;338:959-64.
31. Martrick GD, Danner RL, Ceska M, Suffredini AF. Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agent. J Exp Med. 1991;173:1021-4.
32. Matsushima K, Morishita K, Yoshimura T et al. Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J Exp Med. 1988;167:1883.
33. Moos AB, Baecher-Steppan L, Kerkviet NI. Acute inflammatory response to sheep red blood cells in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: the role of proinflammatory cytokines, IL-1 and TNF. Toxicol Appl Pharmacol. 1994;127:331-5.
34. Nakanishi Y, Shigematsu N, Kurita Y et al. Respiratory involvement and immune status in Yusho patients. Environ Health Perspect. 1985;59:31-6.
35. Nebert DW. Genetic control of carcinogen metabolism leading to individual differences in cancer risk. Biochimie. 1978; 60:1019-29.
36. Nebert DW. The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects. Crit Rev Toxicol. 1990;20:153-74.
37. Noah TL, Yankaskas JR, Carson JL et al. Tight junctions and mucin mRNA in BEAS-2B cells. In Vitro Cell Dev Biol Animal. 1995;31:738-40.
38. Omiecinski C, Redlich CA, Costa P. Induction and developmental expression of cytochrome P4501A messenger RNA in rat and human tissues: detection by polymerase chain reaction. Cancer Res. 1990;50:4315-21.
39. Osborne R, Cook JC, Dold KM, Ross L, Gaido K, Greenlee WF. TCDD receptor: mechanisms of altered growth regulation in normal and transformed human keratinocytes. In: Langenbach R et al., eds. Tumor promotors: biological approaches for mechanistic studies and assay systems. New York: Raven Press; 1988:407-16.
40. Overby LH, Nishio S, Weir A, Carver GT, Plopper CG, Philpot RM. Distribution of cytochrome P450 IA1 and NADPH-cytochrome P450 reductase in lungs of rabbits treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: ultrastructural immunolocalization and in situ hybridization. Mol Pharmacol. 1992;41:1039-46.
41. Poland A, Knutson J. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol. 1982;22:517-54.
42. Ptashne K, Brothers L, Axline SG, Cohen SN Aryl hydrocarbon induction in mouse peritoneal macrophages and blood-derived human macrophages. Proc Soc Exp Biol Med. 1974;146:585-9.
43. Schweiz BA, Norris M, Sparschu GL et al. Toxicology of chlorinated dibenzo-p-dioxins. Environ Health Perspect. 1973;5:87-99.
44. Song B-J, Gelboin HV, Park SS, Tsikos GC, Friedman FK. Monoclonal antibody-directed radioimmunoassay detects cytochrome P450 in human placenta and lymphocytes. Science. 1985;228:490-2.
45. Standiford TJ, Kunkel SL, Basha MA et al. Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. J Clin Invest. 1990;86:1945-53.
46. Sutler TR, Guzman K, Dold KM, Greenlee WF. Targets for dioxin: genes of plasminogen activator inhibitor-2 and interleukin-1β. Science. 1991;254:415-7.
47. Sylvester I, Rankin JA, Yoshimura T, Tanaka S, Leonard E. Secretion of neutrophil attractant/activation protein by lipopolysaccharide-stimulated lung macrophages determined by both enzyme-linked immunosorbent assay and N-terminal sequence analysis. Am Rev Respir Dis. 1990;141:683-8.
48. Taylor MJ, Clark GC, Atkins ZZ, Lucier G, Luster MI. 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the release of tumor necrosis factor-alpha (TNF-α) and induced ethoxyresorufin-O-deethylase (EROD) activity in rat Kupffer's cells (Kcs). Toxicologist. 1990;10:276.
49. Ullmer AJ, Flad HD. Discontinuous density gradient separation of human mononuclear leukocytes using percoll as gradient medium. J Immunol Methods. 1979;30:1.
50. 2-terminal amino acid sequence of a T-cell derived lymphokine with growth factor activity for B-cell hybridomas. Proc Natl Acad Sci USA. 1986;83:9679.
51. Vogel Ch, Abel J. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on growth factor expression in the human breast cancer cell line MCF-7. Arch Toxicol. 1995;69:259-65.
52. Vos JG, Kreeftenberg JG, Engel HWB, Minderhoud A, Van Noorle Jansen LM. Studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immune suppression and decreased resistance to infection: endotoxin hypersensitivity, serum zinc concentrations and effect on thymosin treatment. Toxicology. 1978;9:75-86.
53. Weiser WY, Van Niel A, Clark SC, David JR, Remold HG Recombinant human granulocyte/macrophage colony-stimulating factor activates intracellular killing of Leishmania donovani by monocyte-derived macrophages. J Exp Med. 1987;166:1436-46.
54. Wood SC, Holsapple MP. Direct suppression of superantigen-induced IgM secretion in human lymphocytes by 2,3,7,8-TCDD. Toxicol Appl Pharmacol. 1993;122:308-13.
55. Wood SC, Karras JG, Holsapple MP. Integration of the human lymphocyte into immunotoxicological investigations. Fundam Appl Toxicol. 1992;18:450-9.
56. Yoshimura T, Matsushima K, Oppenheim JJ, Leonard EJ. Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL-1). J Immunol. 1987;139:788-93.