Stability of reconstituted indomethacin sodium trihydrate in original vials and polypropylene syringes

American Journal of Health-System Pharmacy

Volumn 55, Issue 2, 1998, Pages 154-158

  Walker, Scott E ^a,b   Gray, Shari ^c   Schmidt, Barbara ^c,d  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HAMILTON HEALTH SCIENCES   (Canada)

^d MCMASTER UNIVERSITY   (Canada)

Author keywords

Antiinflammatory agents; Diluents; Drugs; Glass; Incompatibilities; Indomethacin sodium; Plastics; Polypropylene; Stability; Storage; Syringes; Temperature; Vials; Wa ter for Injection

Indexed keywords

DILUENT; GLASS; INDOMETACIN; PLASTIC; POLYPROPYLENE;

ARTICLE; CONTAINER; DRUG STABILITY; DRUG STORAGE; LIQUID CHROMATOGRAPHY; PH; PRIORITY JOURNAL; SYRINGE; TEMPERATURE;

EID: 0031913058     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajhp/55.2.154     Document Type: Article

References (12)

1. Indocid package insert. Kirkland, Canada: Merck Sharp & Dohme Canada; 1994 Sep 16.
2. Ishisaka DY, Van Vleet J, Marquardt E. Visual compatibility of indomethacin sodium trihydrate with drugs given to neonates by continuous infusion. Am J Hosp Pharm. 1991; 48:2442-3.
3. Thompson DF, Heflin NR. Incompatibility of injectable indomethacin with gentamicin sulfate or tobramycin sulfate. Am J Hosp Pharm. 1992; 49:836,838. Letter.
4. Marquardt ED. Visual compatibility of tolazoline hydrochloride with various medications during simulated Y-site injection. Am J Hosp Pharm. 1990; 47:1802-3.
5. McEvoy GK, ed. AHFS drug information 97. Bethesda, MD: American Society of Health-System Pharmacists; 1997.
6. Taylor RB, Durham DG, Shivji ASH et al. Development of a stability indicating assay for nafimidone [1-(2-naphtholylmethyl) imidazole hydrochloride] by high performance liquid chromatography. J Chromatogr. 1986; 353:51-9.
7. Walker SE, Lau DWC, DeAngelis et al. Mitoxantrone stability in syringes and glass vials and evaluation of leached plasticizers. Can J Hosp Pharm. 1991; 44:143-51.
8. Box GEP, Cox DR. An analysis of transformations. J R Statist Soc Series B. 1964; 26:211-43.
9. Sclove SL. (Y vs X) or (log Y vs X)? Technometrics. 1972; 14:391-403.
10. Trissel LA. Avoiding common flaws in stability and compatibility studies of injectable drugs. Am J Hosp Pharm. 1983; 40:1159-60.
11. Trissel LA, Flora KP. Stability studies: five years later. Am J Hosp Pharm. 1988; 45:1569-71.
12. Stolley D, Strom BL. Sample size calculations for clinical pharmacology studies. Clin Pharmacol Ther. 1986; 39:489-90.