The Role of Transport in Chemical Nephrotoxicity

Toxicologic Pathology

Volumn 26, Issue 1, 1998, Pages 52-57

  Berndt, William O ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

cephalosporin antibiotics; citrinin; mercuric ion; Organic anions; organic cations; p aminohippurate (PAH); probenecid

Indexed keywords

ACETYL(1,2 DICHLOROVINYL)GLUTATHIONE; ACETYLCYSTEINE; CADMIUM; CEFALORIDINE; CEPHALOSPORIN; CITRININ; GLUTATHIONE; MERCURY; PROBENECID; UNCLASSIFIED DRUG;

CHEMICAL ANALYSIS; CHEMICAL INJURY; CONFERENCE PAPER; HUMAN; HUMAN CELL; KIDNEY TUBULE CELL; KIDNEY TUBULE NECROSIS; NEPHROTOXICITY; PRIORITY JOURNAL; SODIUM TRANSPORT;

ANIMALS; BIOLOGICAL TRANSPORT; DRUG TOXICITY; KIDNEY DISEASES; KIDNEY TUBULES, PROXIMAL; METALS, HEAVY; MICE; ORGANIC CHEMICALS; RABBITS; RATS;

EID: 0031912644     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339802600107     Document Type: Article

References (35)

1. Abbott WA, Bridges RJ, and Meister A (1984). Extracellular metabolism of glutathione accounts for its disappearance from the basolateral circulation of the kidney. J. Biol. Chem. 259: 15393-15400.
2. Baggett JM and Berndt WO (1986). The effect of depletion of nonprotein sulfhydryls by diethyl maleate plus buthionine sulfoximine on renal uptake of mercury in the rat. Toxicol. Appl. Pharmacol. 83: 556-652.
3. Berndt WO (1983). Transport of citrinin by rat renal cortex. Arch. Toxicol. 54: 35-40.
4. Berndt WO, Baggett JM, Blacker A, and Houser M (1985). Renal glutathione and mercury uptake by kidney. Fundam. Appl. Toxicol. 5: 832-839.
5. Berndt WO and Hayes AW (1977). Effects of citrinin on renal tubular transport functions in the rat. J. Environ. Pathol. Toxicol. 1: 93-103.
6. Berndt WO and Hayes AW (1982). The effect of probenecid on citrinin-induced nephrotoxicity. Toxicol. Appl. Pharmacol. 64: 118-124.
7. Boumendil-Podevin EF and Podevin RA (1983). Isolation of basolateral and brush border membranes from the kidney cortex–-Vesicle integrity and membrane sidedness of basolateral fraction. Biochim. Biophys. Acta 735: 86-93.
8. Carlton WW, Szczech GM, and Tuite J (1973). Toxicosis produced in dogs by cultures of penicillium citrinun. Toxicol. Appl. Pharmacol. 25: 457.
9. Endou H, Obara T, and Ueno Y (1985). Use of isolated nephron segments and isolated renal cells for the evaluation of nephrotoxicity. In: Renal Heterogeneity and Target Cell Toxicity, PH Bach and EA Lock (eds). John Wiley & Sons, New York, pp. 169–171.
10. Foulkes EC (1978). Renal tubular transport of cadmium metallothionein. Toxicol. Appl. Pharmacol. 45: 505-512.
11. Foulkes EC and Blanck S (1990a). Acute cadmium uptake by rabbit kidneys: Mechanism and effect. Toxicol. Appl. Pharmacol. 102: 464-473.
12. Foulkes EC and Blanck S (1990b). The cadmium inhibition of basolateral amino acid extrusion in rabbit kidney. Fed. Am. Soc. Exp. Biol. J. 4: A547.
13. Grantham JJ (1982). Studies of organic anion and cation transport in isolated segments of proximal tubules. Kidney Int. 22: 519-525.
14. Johnson DR (1982). Role of renal cortical sulfhydryl groups in development of mercury-induced renal toxicity. J. Toxicol. Environ. Health 9: 119-126.
15. Jordan WH, Carlton WW, and Sansing GA (1977). Citrinin mycotoxicosis in the mouse. Food Cosmet. Toxicol. 15: 29-34.
16. Kasher JR, Holohan PD, and Ross CR (1983). Na+ gradient dependent p-aminohippurate (PAH) transport in rat basolateral membrane vesicles. J. Pharmacol. Exp. Ther. 227: 122-129.
17. Kinsella JL, Holohan PD, Pessah NI, and Ross CR (1979). Transport of organic ions in renal cortical luminal and antiluminal membrane vesicles. J. Pharmacol. Exp. Ther. 209: 433-450.
18. Klonne DR and Johnson DR (1983). Amelioration of mercuric chloride-induced acute renal failure by dithiothreitol. Toxicol. Appl. Pharmacol. 70: 459-466.
19. Krogh P, Hald B, and Pedersen EJ (1973). Occurrence of ochratoxin A and citrinin in cereals associated with mycotoxin procine nephropathy. Acta Pathol. Microbiol. Scand. Sect. B 81: 689-695.
20. Lash LH and Anders MW (1989). Uptake of nephrotoxic S-conjugates by isolated renal proximal tubular cells. J. Pharmacol. Exp. Ther. 248: 531-537.
21. Lash LH and Jones DP (1983). Transport of glutathione by renal basal-lateral membrane vesicles. Biochem. Biophys. Res. Commun. 112: 55-60.
22. Lash LH and Jones DP (1984). Renal glutathione transport: Characteristics of the sodium-dependent system in the basal-lateral membrane. J. Biol. Chem. 259: 15393-15400.
23. Lash LJ and Jones DP (1985). Uptake of the glutathione conjugate S-(1, 2-dichlorovinyl) glutathione by renal basal-lateral membrane vesicles and isolated kidney cells. Mol. Pharmacol. 28: 278-282.
24. McKinney TD (1982). Heterogeneity of organic base secretion by proximal tubules. Am. J. Physiol. 243: F404–F407.
25. Richardson RJ and Murphy SD (1975). Effect of glutathione depletion on tissue deposition of methylmercury in rats. Toxicol. Appl. Pharmacol. 31: 505-519.
26. Schaeffer V and Stevens JL (1987a). The transport of S-cysteine conjugates in LLC-PK1 cells and its role in toxicity. Mol. Pharmacol. 31: 506-512.
27. Schaeffer V and Stevens JL (1987b). Mechanism of transport for toxic cysteine conjugates in rat kidney cortex membrane vesicles. Mol. Pharmacol. 32: 293-298.
28. Suzuki S and Ozaki N (1984). The protective effects of thio-containing compounds of mercuric chloride-induced acute inhibition of enzymes from mouse kidney. Toxicology 29: 207-220.
29. Tune BM (1975). Relationship between the transport and toxicity of cephalosoporins in the kidney. J. Infect. Dis. 132: 189-194.
30. Tune BM (1986). The nephrotoxicity of cephalosporin antibiotics–-Structure–activity relationships. Comments Toxicol. 1: 145-170.
31. Tune BM and Hsu C-Y (1990). Mechanisms of beta-lactam antibiotic nephrotoxicity. Toxicol. Lett. 53: 81-86.
32. Ullrich KJ, Rumrich G, Wieland T, and Dekant W (1989). Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney. III. Specificity: Amino acids, then N-methyl, N-acetyl, and N-benzoyl derivatives; glutathione-and cysteine conjugates and di-and oligopeptides. Pfluegler Arch. Eur. J. Physiol. 415: 342-350.
33. Zalups RK (1995). Organic anion transport and action of γ-glutamyltranspeptidase in kidney linked mechanistically to renal tubular uptake of inorganic mercury. Toxicol. Appl. Pharmacol. 132: 289-298.
34. Zalups RK and Minor KH (1985). Luminal and basolateral mechanisms involved in the renal tubular uptake of inorganic mercury. J. Toxicol. Environ. Health 46: 73-100.
35. Zhang G and Stevens JL (1989). Transport and activation of S-(1,2-dichlorovinyl)-L-cysteine and N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine in rat kidney proximal tubules. Toxicol. Appl. Pharmacol. 100: 51-61.