Formation of hydroxyfuranone and hydroxypyranone derivatives with DNA- breaking activity in the Maillard reaction of glucose and albumin under physiological conditions

Biological and Pharmaceutical Bulletin

Volumn 21, Issue 2, 1998, Pages 102-104

  Hiramoto, Kazuyuki ^a   Ishihara, Akira ^a   Sakui, Norihiro ^b   Daishima, Shigeki ^b   Kikugawa, Kiyomi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b YOKOGAWA ANALYTICAL SYSTEMS INC   (Japan)

Author keywords

Bovine serum albumin (BSA); DNA breaking; Glucose; Hydroxyfuranone; Hydroxypyranone; Maillard reaction

Indexed keywords

2,3 DIHYDRO 3,5 DIHYDROXY 6 METHYL 4H PYRAN 4 ONE; 2,5 DIMETHYL 4 HYDROXY 3(2H) FURANONE; 4 HYDROXY 5 METHYL 3(2H) FURANONE; ALBUMIN; DNA; FURANONE DERIVATIVE; GLUCOSE; PYRAN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DNA STRAND BREAKAGE; DRUG SYNTHESIS; GLYCATION; REACTION ANALYSIS;

EID: 0031912294     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.21.102     Document Type: Article

References (10)

1. Hiramoto K., Kato T., Kikugawa K., Mutat. Res., 285, 191-198 (1993).
2. Hiramoto K., Kido K., Kikugawa K., J. Agric. Food Chem., 42, 689-694 (1994).
3. Hiramoto K., Sekiguchi K., Ayuha K., Aso-o R., Moriya N., Kato T., Kikugawa K., Mutat. Res., 359, 119-132 (1996).
4. Hiramoto K., Sekiguchi K., Aso-o R., Ayuha K., Ni-iyama H., Kato T., Kikugawa K., Food Chem. Toxicol., 33, 803-814 (1995).
5. Hiramoto K., Nasuhara A., Michikoshi K., Kato T., Kikugawa K., Mutat. Res., 395, 47-56 (1997).
6. Hiramoto K., Aso-o R., Ni-iyama H., Hikage S., Kato T., Kikugawa K., Mutat. Res., 359, 17-24 (1996).
7. Li X., Hiramoto K., Yoshida M., Kato T., Kikugawa K., Food Chem. Toxicol., in press.
8. Johnson P. H., Grossman L. I., Biochemistry, 16, 4217-4225 (1977).
9. Sakurai T., Tsuchiya S., FEBS Lett., 236, 406-410 (1988).
10. Mullarkey C. J., Edelstein D., Brownlee M., Biochem. Biophys. Res. Commun., 173, 932-393 (1990).