메뉴 건너뛰기




Volumn 49, Issue SUPPL. 1, 1998, Pages 30-36

The molecular basis of hypopituitarism

Author keywords

Combined pituitary hormone deficiency; Gene expression; Gene mutations; Gene regulation; Hypopituitarism; pit 1; Pituitary development; Retinoic acid; Zn 15

Indexed keywords

DNA; ESTROGEN RECEPTOR; TRANSCRIPTION FACTOR PIT 1; ZINC FINGER PROTEIN;

EID: 0031911305     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053065     Document Type: Conference Paper
Times cited : (23)

References (40)
  • 2
    • 0024277966 scopus 로고
    • The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein
    • Bodner M, Castrill JL, Theill LE, Deerinck T, Ellisman M, Karin M: The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell 1988;55:505-518.
    • (1988) Cell , vol.55 , pp. 505-518
    • Bodner, M.1    Castrill, J.L.2    Theill, L.E.3    Deerinck, T.4    Ellisman, M.5    Karin, M.6
  • 3
    • 0025286831 scopus 로고
    • Pituitary cell phenotypes involve cell-specific pit-1 mRNS translation and synergistic interactions with other classes of transcription factors
    • Simmons DM, Voss JW. Ingraham HA, Holloway JM, Broide RS, Rosenfeld MG, Swanson LW: Pituitary cell phenotypes involve cell-specific pit-1 mRNS translation and synergistic interactions with other classes of transcription factors. Genes Dev 1990;4:695-711.
    • (1990) Genes Dev , vol.4 , pp. 695-711
    • Simmons, D.M.1    Voss, J.W.2    Ingraham, H.A.3    Holloway, J.M.4    Broide, R.S.5    Rosenfeld, M.G.6    Swanson, L.W.7
  • 4
    • 0026091281 scopus 로고
    • TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins
    • Drolet DW, Scully KM, Simmons DM, Wegner M, Chu K, Swanson LW, Rosenfeld MG: TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes Dev 1991;5:1739-1753.
    • (1991) Genes Dev , vol.5 , pp. 1739-1753
    • Drolet, D.W.1    Scully, K.M.2    Simmons, D.M.3    Wegner, M.4    Chu, K.5    Swanson, L.W.6    Rosenfeld, M.G.7
  • 6
    • 0025339078 scopus 로고
    • The POU-specific domain of pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent pit-1 - pit-1 interactions
    • Ingraham HA, Flynn SE, Voss JW, Albert VR, Kapiloff MS, Wilson L, Rosenfeld MG: The POU-specific domain of pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent pit-1 - pit-1 interactions. Cell 1990;61:1021-1033.
    • (1990) Cell , vol.61 , pp. 1021-1033
    • Ingraham, H.A.1    Flynn, S.E.2    Voss, J.W.3    Albert, V.R.4    Kapiloff, M.S.5    Wilson, L.6    Rosenfeld, M.G.7
  • 7
    • 0025771309 scopus 로고
    • Alternate translation initiation site usage results in two structurally distinct forms of pit-1
    • Voss JW, Yao TP, Rosenfeld MG: Alternate translation initiation site usage results in two structurally distinct forms of pit-1. J Biol Chem 1991;266:12832-12835.
    • (1991) J Biol Chem , vol.266 , pp. 12832-12835
    • Voss, J.W.1    Yao, T.P.2    Rosenfeld, M.G.3
  • 8
    • 0026578097 scopus 로고
    • Functional isoforms of pit-1 generated by alternative messenger RNA splicing
    • Konzak KE, Moore DD: Functional isoforms of pit-1 generated by alternative messenger RNA splicing. Mol Endocrinol 1991;6:241-247.
    • (1991) Mol Endocrinol , vol.6 , pp. 241-247
    • Konzak, K.E.1    Moore, D.D.2
  • 10
    • 0028944265 scopus 로고
    • A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1/PIT-1 gene
    • Delhase M, Vila V, Hooghe-Peters EL, Castrillo JL: A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1/PIT-1 gene. Gene 1995;155:273-275.
    • (1995) Gene , vol.155 , pp. 273-275
    • Delhase, M.1    Vila, V.2    Hooghe-Peters, E.L.3    Castrillo, J.L.4
  • 11
    • 85003066076 scopus 로고
    • An alternative pit-1 RNA splicing product reveals modular binding and nonmodular transcriptional activities of the POU-specific domain
    • Voss JW, Wilson L, Rhodes SJ, Rosenfeld MG: An alternative pit-1 RNA splicing product reveals modular binding and nonmodular transcriptional activities of the POU-specific domain. Mol Endocrinol 1993;7:1551-1560.
    • (1993) Mol Endocrinol , vol.7 , pp. 1551-1560
    • Voss, J.W.1    Wilson, L.2    Rhodes, S.J.3    Rosenfeld, M.G.4
  • 12
    • 0028300041 scopus 로고
    • An alternatively spliced form of pit-1 represses prolactin gene expression
    • Day RN, Day KH: An alternatively spliced form of pit-1 represses prolactin gene expression. Mol Endocrinol 1994;8:374-381.
    • (1994) Mol Endocrinol , vol.8 , pp. 374-381
    • Day, R.N.1    Day, K.H.2
  • 13
    • 0027385347 scopus 로고
    • A thyrotroph-specific variant of pit-1 transactivated the thyrotropin promoter
    • Haugen BR, Wood WM, Gordon DF, Ridgway EC: A thyrotroph-specific variant of pit-1 transactivated the thyrotropin promoter. J Biol Chem 1993;268:20818-20824.
    • (1993) J Biol Chem , vol.268 , pp. 20818-20824
    • Haugen, B.R.1    Wood, W.M.2    Gordon, D.F.3    Ridgway, E.C.4
  • 14
    • 0025879084 scopus 로고
    • Variable effects of phosphorylation of pit-1 dictated by the DNA response elements
    • Kapiloff MS, Fakash Y, Wegner M, Rosenfeld MG: Variable effects of phosphorylation of pit-1 dictated by the DNA response elements. Science 1991;253:786-789.
    • (1991) Science , vol.253 , pp. 786-789
    • Kapiloff, M.S.1    Fakash, Y.2    Wegner, M.3    Rosenfeld, M.G.4
  • 15
    • 0028117686 scopus 로고
    • pit-1 binding sites mediate transcriptional responses to cyclic adenosine 3′,5′-monophosphate through a mechanism that does not require inducible phosphorylation of pit-1
    • Okimura Y, Howard PW, Maurer RA: pit-1 binding sites mediate transcriptional responses to cyclic adenosine 3′,5′-monophosphate through a mechanism that does not require inducible phosphorylation of pit-1. Mol Endocrinol 1994;8:1559-1565.
    • (1994) Mol Endocrinol , vol.8 , pp. 1559-1565
    • Okimura, Y.1    Howard, P.W.2    Maurer, R.A.3
  • 16
    • 0026754225 scopus 로고
    • Hormonal regulation of the thyrotropinβ-subunit gene by phosphorylation of the pituitary-specific transcription factor pit-1
    • Steinfelder HJ, Radovick S, Wondisford FE: Hormonal regulation of the thyrotropinβ-subunit gene by phosphorylation of the pituitary-specific transcription factor pit-1. Proc Natl Acad Sci USA 1992;89:5942-5945.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5942-5945
    • Steinfelder, H.J.1    Radovick, S.2    Wondisford, F.E.3
  • 17
    • 0023900566 scopus 로고
    • Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor
    • Nelson C, Albert VR, Elsholtz HP, Lu LI-W, Rosenfeld MG: Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor. Science 1988;239:1400-1405.
    • (1988) Science , vol.239 , pp. 1400-1405
    • Nelson, C.1    Albert, V.R.2    Elsholtz, H.P.3    Lu, L.I.-W.4    Rosenfeld, M.G.5
  • 18
    • 0027257302 scopus 로고
    • Identification of a novel zinc finger protein binding a conserved element critical for pit-1 dependent growth hormone gene expression
    • Lipkin SM, Näär AM, Kalla KA, Sack RA, Rosenfeld MG: Identification of a novel zinc finger protein binding a conserved element critical for pit-1 dependent growth hormone gene expression. Genes Dev 1993;7:1674-1687.
    • (1993) Genes Dev , vol.7 , pp. 1674-1687
    • Lipkin, S.M.1    Näär, A.M.2    Kalla, K.A.3    Sack, R.A.4    Rosenfeld, M.G.5
  • 19
    • 0024278703 scopus 로고
    • Rat growth hormone gene expression: Both cell-specific and thyroid hormone response elements are required for thyroid hormone regulation
    • Ye ZS, Forman BM, Aranda A, Pascual A, Park HY, Casanova J, Samuels HH: Rat growth hormone gene expression: Both cell-specific and thyroid hormone response elements are required for thyroid hormone regulation. J Biol Chem 1988;263:7821-7829.
    • (1988) J Biol Chem , vol.263 , pp. 7821-7829
    • Ye, Z.S.1    Forman, B.M.2    Aranda, A.3    Pascual, A.4    Park, H.Y.5    Casanova, J.6    Samuels, H.H.7
  • 20
    • 0027298617 scopus 로고
    • Synergistic interactions between pit-1 and other elements are required for effective somatotroph rat growth hormone gene expression in transgenic mice
    • Lira SA, Kalla KA, Glass CK, Drolet DW, Rosenfeld MG: Synergistic interactions between pit-1 and other elements are required for effective somatotroph rat growth hormone gene expression in transgenic mice. Mol Endocrinol 1993;7:694-701.
    • (1993) Mol Endocrinol , vol.7 , pp. 694-701
    • Lira, S.A.1    Kalla, K.A.2    Glass, C.K.3    Drolet, D.W.4    Rosenfeld, M.G.5
  • 21
    • 0027447283 scopus 로고
    • Ligand-dependent, Pit-1/ growth hormone factor-1-independent transcriptional stimulation of rat growth hormone gene expression by thyroid hormone receptors in vitro
    • Suen CS, Chin WW: Ligand-dependent, Pit-1/ growth hormone factor-1-independent transcriptional stimulation of rat growth hormone gene expression by thyroid hormone receptors in vitro. Mol Cell Biol 1993;13:1719-1727.
    • (1993) Mol Cell Biol , vol.13 , pp. 1719-1727
    • Suen, C.S.1    Chin, W.W.2
  • 22
    • 0021828930 scopus 로고
    • Independent effects of growth hormone releasing factor on growth hormone release and gene transcription
    • Barinaga M, Bilezikjian LM, Vale WW, Rosenfeld MG, Evans RM: Independent effects of growth hormone releasing factor on growth hormone release and gene transcription. Nature 1985;314:279-281.
    • (1985) Nature , vol.314 , pp. 279-281
    • Barinaga, M.1    Bilezikjian, L.M.2    Vale, W.W.3    Rosenfeld, M.G.4    Evans, R.M.5
  • 23
    • 0020593740 scopus 로고
    • Stimulation of adenosine 3′,5′-monophosphate production by growth hormone-releasing factor and its inhibition by somatostatin in anterior pituitary cell in vitro
    • Bilezikjian LM, Vale MM: Stimulation of adenosine 3′,5′-monophosphate production by growth hormone-releasing factor and its inhibition by somatostatin in anterior pituitary cell in vitro. Endocrinology 1983;113:1726-1731.
    • (1983) Endocrinology , vol.113 , pp. 1726-1731
    • Bilezikjian, L.M.1    Vale, M.M.2
  • 24
    • 0025131065 scopus 로고
    • The homeodomain protein, pit-1/GHF-1, is capable of binding to and activating cell-specific elements of both the growth hormone and prolactin gene promoters
    • Fox SR, Jong MTC, Casanova J, Ye ZS, Stanley F, Samuels HH: The homeodomain protein, pit-1/GHF-1, is capable of binding to and activating cell-specific elements of both the growth hormone and prolactin gene promoters. Mol Endocrinol 1990;4:1069-1080.
    • (1990) Mol Endocrinol , vol.4 , pp. 1069-1080
    • Fox, S.R.1    Jong, M.T.C.2    Casanova, J.3    Ye, Z.S.4    Stanley, F.5    Samuels, H.H.6
  • 25
    • 0023928814 scopus 로고
    • A single domain of the estrogen receptor confers deoxyribonucleic acid binding and transcriptional activation of the prolactin gene
    • Waterman ML, Adler S, Nelson C, Greene GL, Evans RM, Rosenfeld MG: A single domain of the estrogen receptor confers deoxyribonucleic acid binding and transcriptional activation of the prolactin gene. Mol Endocrinol 1988; 2(A24):14-21.
    • (1988) Mol Endocrinol , vol.2 , Issue.A24 , pp. 14-21
    • Waterman, M.L.1    Adler, S.2    Nelson, C.3    Greene, G.L.4    Evans, R.M.5    Rosenfeld, M.G.6
  • 26
    • 0025671979 scopus 로고
    • Both pit-1 and the estrogen receptor are required for estrogen responsiveness of rat prolactin gene
    • Day RN, Koike S, Sakai M, Muramatsu M, Maurer RA: Both pit-1 and the estrogen receptor are required for estrogen responsiveness of rat prolactin gene. Mol Endocrinol 1990;4: 1964-1971.
    • (1990) Mol Endocrinol , vol.4 , pp. 1964-1971
    • Day, R.N.1    Koike, S.2    Sakai, M.3    Muramatsu, M.4    Maurer, R.A.5
  • 27
    • 0026345421 scopus 로고
    • Thyrotropin-releasing hormone regulation of human TSHB expression: Role of a pituitary-specific transcription factor (pit-1/GHF-1) and potential interaction with a thyroid hormone-inhibitory element
    • Steinfelder HJ, Hauser P, Nakayama Y, Radovick S, McClaskey JH, Taylor T, Weintraub BD, Wondisford FE: Thyrotropin-releasing hormone regulation of human TSHB expression: Role of a pituitary-specific transcription factor (pit-1/GHF-1) and potential interaction with a thyroid hormone-inhibitory element. Proc Natl Acad Sci USA 1991;88:3130-3134.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3130-3134
    • Steinfelder, H.J.1    Hauser, P.2    Nakayama, Y.3    Radovick, S.4    McClaskey, J.H.5    Taylor, T.6    Weintraub, B.D.7    Wondisford, F.E.8
  • 28
    • 0026561583 scopus 로고
    • Role of a pituitary-specific transcription factor (pit-1/GHF-1) or a closely related protein in cAMP regulation of human thyrotropin-subunit gene expression
    • Steinfelder JH, Hauser P, Nakayama Y, Radovick S, McClaskey JH, Taylor T, Weintraub BD, Wondisford FE: Role of a pituitary-specific transcription factor (pit-1/GHF-1) or a closely related protein in cAMP regulation of human thyrotropin-subunit gene expression. J Clin Invest 1992;89:409-419.
    • (1992) J Clin Invest , vol.89 , pp. 409-419
    • Steinfelder, J.H.1    Hauser, P.2    Nakayama, Y.3    Radovick, S.4    McClaskey, J.H.5    Taylor, T.6    Weintraub, B.D.7    Wondisford, F.E.8
  • 29
    • 2642648228 scopus 로고
    • Autoregulation of pit-1 gene expression mediated by two cisactive promoter elements
    • Chen R, Ingraham HA, Treacy MN, Albert VR, Wilson L, Rosenfeld MG: Autoregulation of pit-1 gene expression mediated by two cisactive promoter elements. Nature 1990;347: 528-533.
    • (1990) Nature , vol.347 , pp. 528-533
    • Chen, R.1    Ingraham, H.A.2    Treacy, M.N.3    Albert, V.R.4    Wilson, L.5    Rosenfeld, M.G.6
  • 30
    • 0025322841 scopus 로고
    • Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues
    • McCormick A, Brady H, Theill LE, Karin M: Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues. Nature 1990;345:829-832.
    • (1990) Nature , vol.345 , pp. 829-832
    • McCormick, A.1    Brady, H.2    Theill, L.E.3    Karin, M.4
  • 31
    • 0025014024 scopus 로고
    • Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1
    • Li S, Crenshaw EB III, Rawson EJ, Simmons DM, Swanson LW, Rosenfeld MG: Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature 1990;347:528-533.
    • (1990) Nature , vol.347 , pp. 528-533
    • Li, S.1    Crenshaw III, E.B.2    Rawson, E.J.3    Simmons, D.M.4    Swanson, L.W.5    Rosenfeld, M.G.6
  • 32
    • 0026767630 scopus 로고
    • A mutation in th POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency
    • Radovick S, Nationa M, Du Yuefen, Berg LA, Weintraub BD, Wondisford F: A mutation in th POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency. Science 1992;257:1115-1118.
    • (1992) Science , vol.257 , pp. 1115-1118
    • Radovick, S.1    Nationa, M.2    Du Yuefen3    Berg, L.A.4    Weintraub, B.D.5    Wondisford, F.6
  • 35
    • 0027980595 scopus 로고
    • Monoallelic expression of normal mRNA in the PIT1 mutation heterozygotes with normal phenotype and biallelic expression in the abnormal phenotype
    • Okamoto N, Wada Y, Ida S, Moga R, Ozono K, Chiyo KA, Hayashi A, Tatsumi KI: Monoallelic expression of normal mRNA in the PIT1 mutation heterozygotes with normal phenotype and biallelic expression in the abnormal phenotype. Hum Mol Genet 1994;3:1565-1568.
    • (1994) Hum Mol Genet , vol.3 , pp. 1565-1568
    • Okamoto, N.1    Wada, Y.2    Ida, S.3    Moga, R.4    Ozono, K.5    Chiyo, K.A.6    Hayashi, A.7    Tatsumi, K.I.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.