Evaluation of cisplatin and cyclosporin A in recurrent platinum- resistant ovarian cancer: A phase II study of the gynecologic oncology group

Gynecologic Oncology

Volumn 68, Issue 1, 1998, Pages 45-46

  Manetta, Alberto ^a   Blessing, John A ^b   Hurteau, Jean A ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cisplatin; Cyclosperin A; Platinum resistant ovarian cancer

Indexed keywords

ALTRETAMINE; CISPLATIN; CYCLOSPORIN A; MITOXANTRONE; NAVELBINE; PACLITAXEL;

ARTICLE; BLOOD TOXICITY; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; FEMALE; HUMAN; NEPHROTOXICITY; OVARY CANCER; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL;

EID: 0031910773     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1006/gyno.1997.4887     Document Type: Article

References (8)

1. Slater L M, Sweet P, Stupecky M, Gupta S. Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro. Clin Invest. 77:1986;1405-1408.
2. Stratton J A, DiSaia P J. Reversal of cisplatinum (CSSP) resistance by cyclosporin A (CsA) in xenografts of fresh human ovarian carcinoma. Proc Am Assoc Cancer Res. 29:1988;479.
3. Chambers S K, Hart W N, Hadin M W, Handschumacher R T. Cyclosporin A and a non-immunosuppressive homolog can sensitize parent and multi-drug resistant ovarian cell lines to doxorubicin. Proc Am Assoc Cancer Res. 29:1988;313.
4. Manetta A, Boyle J, Berman M L, DiSaia P H, Lentz S, Liao S Y, Mutch D, Slater L. Cyclosporin enhancement of cisplatin chemotherapy in patients with refractory cancer: A Gynecologic Oncology Group study. Cancer. 73:1994;196-199.
5. Moscow J A, Cowan K H. Multi-drug resistance. J Natl Cancer Inst. 80:1988;14-20.
6. Scanlon K J, Jiao L, Funato T, Wang W, Tone T, Rossi J J, Kashani-Sabet M. Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein. Proc Natl Acad Sci USA. 88:1991;10591-10595.
7. Kashani-Sabet M, Wang W, Scanlon K. Cyclosporin A suppresses cisplatin-induced c-fos gene expression in ovarian carcinoma cells. J Biol Chem. 2655:1990;11285-11288.
8. Blessing J A. Design, Analysis and Interpretation of Chemotherapy Trials in Gynecologic Cancer. Chemotherapy of Gynecologic Cancer. 1990;AR Liss, Scientific and Medical Publications, New York. p. 63-97.