β-Lactamase production diminishes the prophylactic efficacy of ampicillin and cefazolin in a guinea pig model of Staphylococcus aureus wound infection

Journal of Infectious Diseases

Volumn 177, Issue 3, 1998, Pages 701-706

  Kernodle, Douglas S ^a   Voladri, Rama K R ^b   Kaiser, Allen B ^b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; BETA LACTAMASE; CEFAZOLIN; GENTAMICIN; PLACEBO; POLYMYXIN B;

ABSCESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC PROPHYLAXIS; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GUINEA PIG; INFECTION RATE; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STRAIN DIFFERENCE; SUBCUTANEOUS DRUG ADMINISTRATION; WOUND INFECTION;

EID: 0031910755     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/514231     Document Type: Article

References (7)

1. Mayhall CG. Surgical infections including burns. In: Wenzel RP, ed. Prevention and control of nosocomial infections. Baltimore: Williams & Wilkins, 1993:614-64.
2. Haley RW, Culver DH, White JW, Morgan WM, Emori TG. The nationwide nosocomial infection rate: a new need for vital statistics. Am J Epidemiol 1985;121:159-67.
3. Wenzel RP. Preoperative antibiotic prophylaxis. N Engl J Med 1992;326:337-9.
4. Schaberg DR, Culver DH, Gaynes RP. Major trends in the microbial etiology of nosocomial infection. Am J Med 1991;91(suppl 3B):72S-5S.
5. Elek SD, Conen PE. The virulence of Staphylococcus pyogenes for man: a study of the problems of wound infection. Br J Exp Pathol 1957;38:573-86.
6. Kaiser AB, Kernodle DS, Parker RA. Low-inoculum model of surgical wound infection. J Infect Dis 1992;166:393-9.
7. Kaiser AB, Clayson KR, Mulherin JL, et al. Antibiotic prophylaxis in vascular surgery. Ann Surg 1978;188:283-9.