Effective GC-MS procedure for detecting iso-LSD in urine after base- catalyzed conversion to LSD

Clinical Chemistry

Volumn 44, Issue 2, 1998, Pages 287-292

  Clarkson, Edward D ^a   Lesser, David ^a   Paul, Buddha D ^b,c  

^a Space and Naval Warfare Systems Center Pacific   (United States)

^b ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^c AFIP Annex   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ERGOT ALKALOID; LYSERGIDE; TRIMETHYLSILYL DERIVATIVE;

ARTICLE; CATALYSIS; FRACTIONATION; GAS CHROMATOGRAPHY; HYDROLYSIS; LETHAL DOSE; MASS SPECTROMETRY; METHODOLOGY; PROTON TRANSPORT; QUANTITATIVE DIAGNOSIS; RESPIRATORY FAILURE;

ETHANOL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; ISOMERISM; LYSERGIC ACID DIETHYLAMIDE; MOLECULAR STRUCTURE; SENSITIVITY AND SPECIFICITY; SUBSTANCE-RELATED DISORDERS; TIME FACTORS;

EID: 0031910563     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Isabell H. Comparison of the reactions induced by psilocybin and LSD-25 in man. Psychopharmacologia 1959;1:29-38.
2. Wolbach AB Jr, Isabell H, Miner EJ. Cross tolerance between mescaline and LSD-25 with a comparison of the mescaline and LSD reactions. Psychopharmacologia 1962;3:1-14.
3. Pradhan SN, Hollister LE. Abuse of LSD and other hallicinogenic drugs. In: Pradhan SN, Dutta SN, eds. Drug abuse clinical and basic aspects. St Louis: The C.V. Mosby Co., 1977:274-89.
4. Hoffer A. D-Lysergic acid diethylamide (LSD): a review of its present status. Clin Pharm Ther 1965;6:183-255.
5. Curry AS. Advances in forensic and clinical toxicology. Boca Raton, FL: CRC Press, 1972:41-9.
6. Stoll A, Hofmann A. Die alkaloide der ergotoxingruppe: ergocristin, ergokryptin und ergocornin. Helv Chim Acta 1943;26:1570-601.
7. Hofmann A, Tscherter H. Isolierung von lysergsaure-alkaloiden aus der mexikanischen zauberdroge Ololiuqui (Rivea corymbosa L. Hall. f). Experientia 1960;16:414.
8. Smith S, Timmis GM. The alkaloids of ergot. Part VI. Ergometrinine. J Chem Soc 1936:1166-9.
9. Smith S, Timmis GM. The alkaloids of ergot. Part VII. Isoergine and isolysergic acids. J Chem Soc 1936:1440-4.
10. Rutschmann J, Stadler PA. Chemical background. In: Berde B, Schild HO, eds. Handbook of experimental pharmacology, ergot alkaloids and related compounds, Vol. 49. Berlin: Springer-Verlag, 1978:29-85.
11. Stenlake JB. Dissociation constants of the lysergic acids. J Chem Soc 1955:1626-8.
12. Leemann HG, Fabbri S. Uber die absolute konfiguration der lysergsaure. HeIv Chim Acta 1959;42:2696-709.
13. Foltz RL, Foltz RB. Lysergic acid diethylamide (LSD). In: Baselt RC, ed. Advances in analytical toxicology, Vol. II. Chicago: Year Book Medical Publishers, 1989:140-58.
14. Axelrod J, Brady RO, Witkop B, Evarts EV. The distribution and metabolism of lysergic acid diethylamide. Ann N Y Acad Sci 1957;66:435-44.
15. 14C]iso-LSD in rat. Biochem Pharmcol 1979;28:3093-101.
16. Nelson CC, Foltz RL. Determination of lysergic acid diethylamide (LSD), iso-LSD, and N-demethyl-LSD in body fluids by gas chromatography/tandem mass spectrometry. Anal Chem 1992; 64:1578-85.
17. Paul BD, Mitchell JM, Burbage R, Moy M, Sroka R. Gas chromatography-electron impact mass fragmentometric determination of lysergic acid diethylamide in urine. J Chromatogr 1990;529: 103-12.
18. Isabell H, Miner EJ, Logan CR. Relationships of psychotomimetic to anti-serotonin potencies of congeners of lysergic acid diethylamide (LSD-25). Psychopharmacologia 1959;1:20-8.