Age-dependent changes in androgen receptor immunoreactivity in motoneurons of the spinal nucleus of the bulbocavernosus of male rats

Neuroscience Letters

Volumn 243, Issue 1-3, 1998, Pages 29-32

  Matsumoto, Akira ^a   Prins, Gail S ^b  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Aging; Androgen receptor; Immunohistochemistry; Motoneuron; Testosterone

Indexed keywords

ANDROGEN RECEPTOR; POLYCLONAL ANTIBODY; TESTOSTERONE;

ADOLESCENT; AGED; AGING; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CORPUS CAVERNOSUM; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD MOTONEURON; TESTOSTERONE BLOOD LEVEL;

EID: 0031910548     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00078-0     Document Type: Article

References (23)

1. Abercrombie M. Estimation of nuclear populations from microtome sections. Anat. Rec. 94:1946;239-247.
2. Al-Shamma H.A., Arnold A.P. Importance of target innervation in recovery from axotomy-induced loss of androgen receptor in rat perineal motoneurons. J. Neurobiol. 28:1995;341-353.
3. Al-Shamma H.A., Arnold A.P. Brain-derived neurotrophic factor regulates expression of androgen receptors in perineal motoneurons. Proc. Natl. Acad. Sci. USA. 94:1997;1521-1526.
4. Breedlove S.M., Arnold A.P. Hormone accumulation in a sexually dimorphic motor nucleus of the rat spinal cord. Science. 210:1980;564-566.
5. Burgess L.H., Handa R.J. Hormonal regulation of androgen receptor mRNA in the brain and anterior pituitary gland of the male rat. Mol. Brain Res. 19:1993;31-38.
6. Chambers K.C., Thornton J.E., Roselli C.E. Age-related deficits in brain androgen binding and metabolism, testosterone, and sexual behavior of male rats. Neurobiol. Aging. 12:1991;123-130.
7. Dube J.Y., Lesage R., Tremblay R.R. Androgen and estrogen binding in rat skeletal and perineal muscles. Can. J. Biochem. 54:1976;50-55.
8. Ghanadian R., Lewis J.G., Chisholm G.D. Serum testosterone and dihydrotestosterone changes with age in rat. Steroids. 25:1975;753-762.
9. Greenstein B.D. Androgen receptors in the rat brain, anterior pituitary gland and ventral prostate gland: effects of orchidectomy and ageing. J. Endocrinol. 81:1979;75-81.
10. Haji M., Kato K., Nawata H., Ibayashi H. Age-related changes in the concentrations of cytosol receptors for sex steroid hormones in the hypothalamus and pituitary gland of the rat. Brain Res. 204:1981;373-386.
11. Johnson H., Hökfelt T., Ulfake B. Decreased expression of trkB and trkC mRNAs in spinal motoneurons of aged rats. Eur. J. Neurosci. 8:1996;494-499.
12. Krey L.C., McGinnis M.Y. Time-course of the appearance/disappearance of nuclear androgen+receptor complexes in the brain and adenohypophysis following testosterone administration/withdrawal to castrated male rats: relationships with gonadotropin secretion. J. Steroid Biochem. 35:1990;403-408.
13. Larsson K. Sexual activity in senile male rats. J. Gerontol. 13:1958;136-139.
14. Larsson K., Essberg L. Effect of age on the sexual behavior of the male rats. Gerontologia. 6:1962;133-143.
15. Matsumoto A., Arai Y., Prins G.S. Androgenic regulation of androgen receptor immunoreactivity in motoneurons of the spinal nucleus of the bulbocavernosus of male rats. J. Neuroendocrinol. 8:1996;553-559.
16. McGinnis M.Y., Yu W.-H.A. Age-related changes in androgen receptor levels in cranial nerve nuclei of male rats. Brain Res. Bull. 36:1995;581-585.
17. Peng M.T., Hsu H.K., Pi W.P., Wu K.M., Liao C.F., Wan W.C.-M. Pattern of reproductive hormone secretion and disappearance rates of LH and FSH in senile male rats. Gerontology. 29:1983;32-40.
18. Prins G.S., Birch L. Immunocytochemical analysis of androgen receptor along the ducts of the separate rat prostate lobes after androgen withdrawal and replacement. Endocrinology. 132:1993;169-178.
19. Roy A.K., Vellanoweth R.L., Chen S., Supakar P.C., Jung M.H., Song C.S., Chatterjee B. The evolutionary tangle of aging, sex, and reproduction and an experimental approach to its molecular dissection. Exp. Gerontol. 31:1996;83-94.
20. Sachs, B.D. and Meisel, R.L., The physiology of male sexual behavior. In E. Knobil, J.D. Neill, L.L. Ewing, G.S. Greenward, C.L. Markert and D.W. Pfaff (Eds.), The Physiology of Reproduction, Vol. 2, Raven, New York, 1988, pp. 1393-1485.
21. Schröder H.D. Organization of the motoneurons innervating the pelvic muscles of the male rat. J. Comp. Neurol. 192:1980;567-587.
22. Shain S.A., Axelrod L.R. Reduced high affinity 5α-dihydrotestosterone receptor capacity in the ventral prostate of the aging rat. Steroids. 21:1973;801-812.
23. Yamamoto K.R. Steroid receptor regulated transcription of specific genes and gene networks. Annu. Rev. Genet. 19:1985;209-252.