Lack of protection from HIV infection by the mutant HIV coreceptor CCR5 in intravenously HIV infected hemophilia patients

Immunobiology

Volumn 198, Issue 4, 1998, Pages 485-488

  Malo, Antje ^a   Rommel, Franz ^b   Bogner, Johannes ^b   Gruber, Rudi ^a   Schramm, Wolfgang ^b   Goebel, Frank D ^b   Riethmüller, Gerd ^a   Wank, Rudolf ^a,c  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c Institut für Immunologie   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; PLASMA PROTEIN;

ARTICLE; DELETION MUTANT; HEMOPHILIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRAVENOUS DRUG ADMINISTRATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; SEXUALLY TRANSMITTED DISEASE;

EID: 0031908903     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0171-2985(98)80055-7     Document Type: Article

References (5)

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2. DEAN M, CARRINGTON M, GOEDERT J, and OBRIAN SJ. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CRK structural gene. Science 274: 1069.
3. HUANG Y, PAXTON WA, WOLINSKY SM, NEUMANN AU, ZHANG L, HE T, KANG S, CERADINI D, JIN Z, YAZDANBAKHSH K, KUNSTMANN K, ERICKSON D, DRAGON E, LANDAU NR, PHAIR J, HO DD and KOUP RA. 1996. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nature Medicine 2: 1240-1243.
4. SAMSON M, LIBERT F, DORANZ BJ, RUCKER J, LIESNARDT C, FARBER C-M, SARAGOSTI S, LAPOUMEROULIE C, COGNAUX J, FORCEILLE C, MUYLDERMANNS G, VERHOFSTEDE C, BURTONBOY G, GEORGES M, IMAI T, RANA S, YI Y, SMYTH RJ, COLLMANN RG, DOMS RW, VASSART G, and PARMENTIER M. 1996. Resistence to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR5 chemokine receptor gene. Nature 382: 722-725.
5. WALLI R, REINHART B, LUCKOW B, LEDERER E, MALO A, WANK R, SCHLÖNDORFF D, and GOEBEL FD. 1998. HIV infected long term slow progressors heterozygous for Δ32-CCR5 show significantly lower plasma viral load than wild type slow progressors. J. ACQ. Immundef. Synd. In press.