Oxidized low-density lipoprotein inhibits acetylcholine-induced vasorelaxation and increases 5-HT-induced vasoconstriction in isolated human saphenous vein

Journal of Pharmacology and Experimental Therapeutics

Volumn 284, Issue 2, 1998, Pages 637-643

  Zhao, Lifan ^a   Tackett, Randall L ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; NITROPRUSSIDE SODIUM; OXIDIZED LOW DENSITY LIPOPROTEIN; SEROTONIN;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; SAPHENOUS VEIN; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION;

ACETYLCHOLINE; ADULT; ARGININE; ENDOTHELIUM, VASCULAR; HUMANS; LIPOPROTEINS, LDL; MALE; SAPHENOUS VEIN; SEROTONIN; VASOCONSTRICTION; VASODILATION; VASOMOTOR SYSTEM;

EID: 0031908064     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Anderson TJ, Meredith IT, Yeung AC, Frei B, Selwyn AP and Ganz P (1995) The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med 332:488-493.
2. Bode-Böger SM, Böger RH, Kienke S, Junker W and Frölich JC (1996) Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits. Biochem Biophys Res Comm 219:598-603.
3. Böger RH, Bode-Böger SM, Mügge A, Kienke S, Brandes R, Dwenger A and Frölich JC (1995) Supplementation of hypercholesterolemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production. Atherosclerosis 117:273-284.
4. Boulanger CM, Tanner FC, Béa M, Hahn AWA, Werner A and Lüscher TF (1992) Oxidized low density lipoproteins induced mRNA expression and release of endothelin from human and porcine endothelium. Circ Res 70:1191-1197.
5. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM and Panza JA (1994) Investigation of decreased availability of nitric oxide precursor as the mechanism responsible for impaired endothelium-dependent vasodilation in hypercholesterolemic patients. J Am Coll Cardiol 23:844-850.
6. Cazzolato G, Avogaro P and Bittolo-Bon G ( 1991) Characterization of a more electronegatively charged LDL subfraction by ion exchange HPLC. Free Radic Biol Med 11:247-253.
7. Chin JH, Azhar S and Hoffman BB (1992) Inactivation of endothelial derived relaxing factor by oxidized lipoproteins. J Clin Invest 89:10-18.
8. Cox DA and Cohen ML (1996) Selective enhancement of 5-hydroxytryptamine-induced contraction of porcine coronary artery by oxidized low-density lipoprotein. J Pharmacol Exp Ther 276:1095-1103.
9. Creager MA, Gallagher SJ, Girerd XJ, Coleman SM, Dzau VJ and Cooke P (1992) L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest 90:1248-1253.
10. Galle J, Bassenge E and Busse R (1990) Oxidized low density lipoproteins potentiate vasoconstrictions to various agonists by direct interaction with vascular smooth muscle. Circ Res 66:1287-1293.
11. Galle J, Mülsch A, Busse R and Bassenge E (1991) Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-dervived relaxing factor. Arterioscler Thromb 11:198-203.
12. Galle J, Öchslen M, Schollmeyer P and Wanner C (1994) Oxidized lipoproteins inhibit endothelium-dependent vasodilation: Effects of pressure and high-density lipoprotein. Hypertension 23:556-564.
13. Girerd XJ, Hirsch AT, Cooke JP, Dzau VJ and Creager MA (1990) L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. Circ Res 67:1301-1308.
14. Golino P, Piscione F, Willerson JT, Cappelli-Bigazzi M, Focaccio A, Villari B, Indolfi C, Russolillo E, Condorelli M and Chiariello M (1991) Divergent effects of serotonin on coronary-artery dimensions and blood flow in patients with coronary atherosclerosis and control patients. N Eng J Med 324:641-648.
15. Guarnieri C, Giordano E, Muscari C, Grossi L and Caldarera CM (1996) Alphatocopherol pretreatment improves endothelium-dependent vasodilation in aortic strips of young and aging rats exposed to oxidative stress. Mol Cell Biochem 157:223-228.
16. Hayashi T, Fukuto JM, Ignarro LJ and Chaudhuri G (1995) Gender differences in atherosclerosis: Possible role of nitric oxide. J Cardiovasc Pharmacol 26:792-802
17. He Y, Kwan WCP and Steinbrecher UP (1996) Effects of oxidized low 7density lipoprotein on endothelin secretion by cultured endothelial cells and macrophages. Atherosclerosis 119:107-118.
18. Hirata K, Miki N, Kuroda Y, Sakoda T, Kawashima S and Yokoyama M (1995) Low concentration of oxidized low-density lipoprotein and lysophosphatidylcholine upregulate constitutive nitric oxide synthase mRNA expression in bovine aortic endothelial cells. Circ Res 76:958-962.
19. Hodis HN, Kramsch DM, Avogaro P, Bittolo-Bon G, Cazzolato G, Hwang J, Peterson H and Sevanian A (1994) Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-). J Lipid Res 35:669-677.
20. Jeserich M, Münzel T, Just H and Drexler H (1992) Reduced plasma L-arginine in hypercholesterolemia. Lancet 339:561.
21. Keaney JF, Gaziano JM, Xu A, Frei B, Curran-Celentano J, Shwaery GT, Loscalzo J and Vita JA (1993) Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits. Proc Natl Acad Sci USA 90:11880-11884.
22. Kolodgie FD, Virmani R, Rice HE and Mergner WJ (1990) Vascular reactivity during the progression of atherosclerotic plaque: A study in Watanabe heritable hyperlipidemic rabbits. Circ Res 66:1112-1126.
23. Kugiyama K, Kerns SA, Morrisett JD, Roberts R and Henry PD (1990) Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature 344:160-162.
24. Liao JK, Shin WS, Lee WY and Clark SL (1995) Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem 270: 319-324.
25. 2, and ADP. Circulation 79:698-705.
26. Lüscher TF, Diederich D, Siebenmann R, Lehmann K, Stulz P, Segesser LV, Yang Z, Turina M, Grädel E, Weber E and Bühler FR (1988) Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts. N Eng J Med 319:462-467.
27. Maeba R, Maruyama A, Tarutani O, Ueta N and Shimasaki H (1995) Oxidized low-density lipoprotein induces the production of Superoxide by neutrophils. FEBS Letts 377:309-312.
28. Mangin Jr EL, Kugiyama K, Nguy JH, Kerns SA and Henry PD (1993) Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta. Circ Res 72:161-166.
29. Minor Jr RL, Myers PR, Guerra Jr R, Bates JN and Harrison DG (1990) Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest 86:2109-2116.
30. Mügge A, Elwell JH, Peterson TE, Hofmeyer TG, Heistad DD and Harrison DG (1991) Chronic treatment with polyethylene-glycolated Superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits. Circ Res 69:1293-1300.
31. Ohara Y, Peterson TE and Harrison DG (1993) Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 91:2546-2551.
32. Ohgushi M, Kugiyama K, Fukunaga K, Murohara T, Sugiyama S, Miyamoto E and Yasue H (1993) Protein kinase C inhibitors prevent impairment of endothelium-dependent relaxation by oxidatively modified LDL. Arterioscler Thromb 13:1525-1532.
33. Pasini FL, Frigerio C, Giorgi LD, Blardi P and Perri TD (1992) L-arginine plasma concentrations in hypercholesterolemia. Lancet 340:549.
34. Pearson PJ, Lin PJ, Evora PRB and Schaff HV (1993) Endothelium-dependent response of human internal mammary artery to hypoxia. Am J Physiol 264:H376-H380.
35. Plane F, Bruckdorfer KR, Kerr P, Steuer A and Jacobs M (1992) Oxidative modification of low-density lipoproteins and the inhibition of relaxations mediated by endothelium-derived nitric oxide in rabbit aorta. Br J Pharmacol 105:216-222.
36. Pohl U, Heydari N and Galle J (1995) Effects of LDL on intracellular free calcium and nitric oxide-dependent cGMP formation in porcine endothelial cells. Atherosclerosis 117:169-178.
37. Rubanyi GM (1993) The role of endothelium in cardiovascular homeostasis and diseases. J Cardiovasc Pharmacol 22:suppl. 4, S1-S14.
38. Schmidt K, Graier WF, Kostner GM, Mayer B, Böhme E and Kukovetz WR (1991) Stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor is antagonized by oxidized low-density lipoprotein. J Cardiovasc Pharmacol 17: (suppl.3), S83-S88.
39. Shoemaker K, Rubin J, Zumbro GL and Tackett RL (1996) Potential role of EDHF in modulating vascular tone in human saphenous vein. (Abstract) FASEB J 10:A317.
40. Simon BC, Cunningham LD and Cohen RA (1990) Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery. J Clin Invest 86:75-79.
41. Steinberg D and Witztum JL (1990) Lipoproteins and atherogenesis: Current concepts. JAMA 264:3047-3052.
42. Tamai O, Matsuoka H, Itabe H, Wada Y, Kohno K and Imaizumi T (1997) Single LDL apheresis improves endothelium-dependent vasodilation in hypercholesterolemic humans. Circulation 95:76-82.
43. Tanner FC, Noll G, Boulanger CM and Lüscher TF (1991) Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries: Role of scavenger receptor and endothelium-derived nitric oxide. Circulation 83:2012-2020.
44. 1D receptor agonists in the rabbit isolated saphenous vein. Br J Pharmacol 119:35-42.
45. Vallance P, Leone A, Calver A, Collier J and Moncada S (1992) Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339:572-575.
46. Yagi K (1976) A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 15:212-216.
47. Yang Z, Segesser LV, Bauer E, Stulz P, Turina M and Luscher TF (1991) Different activation of the endothelial L-arginine and cyclooxygenase pathway in the human internal mammary artery and saphenous vein. Circ Res 68:52-60.
48. Ylä-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S, Witztum JL and Steinberg D (1989) Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest 84:1086-1095.
49. Yu X, Li Y and Xiong Y (1994) Increase of an endogenous inhibitor of nitric oxide synthesis in serum of high cholesterol fed rabbits. Life Sci 54:753-758.
50. Zeiher AM, Drexler H, Wollschläger H and Just H (1991) Modulation of coronary vasomotor tone in humans: Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 83:391-401.