Renal effects of renin-angiotensin system blockade

Current Opinion in Nephrology and Hypertension

Volumn 7, Issue 2, 1998, Pages 153-158

  Franco, Martha ^a   Paniagua, Ramon ^a   Herrera Acosta, Jaime ^a  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; BRADYKININ; CYCLIC AMP; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; KALLIKREIN; LOOP DIURETIC AGENT; LOSARTAN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLATELET DERIVED GROWTH FACTOR; PROSTAGLANDIN E2; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; RENIN INHIBITOR; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL PROLIFERATION; DRUG EFFECT; EXTRACELLULAR MATRIX; GLOMERULUS FILTRATION RATE; HUMAN; HYPERTENSION; KALLIKREIN KININ SYSTEM; KIDNEY BLOOD FLOW; KIDNEY BLOOD VESSEL; KIDNEY INJURY; KIDNEY TUBULE FUNCTION; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ANGIOTENSIN II; BLOOD VESSELS; HEMODYNAMIC PROCESSES; HUMANS; KIDNEY; KIDNEY TUBULES; RECEPTORS, ANGIOTENSIN; RENAL CIRCULATION; RENIN-ANGIOTENSIN SYSTEM;

EID: 0031907533     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199803000-00003     Document Type: Article

References (44)

1. Ichikawa I, Harris RC. Angiotensin actions in the kidney: renewed insight into the old hormone. Kidney Int 1991; 40:583-596.
2. Harris RC, Becker BN, Cheng HF. Acute and chronic mechanisms for regulating proximal tubule angiotensin II receptor expression. J Am Soc Nephrol 1997; 8:306-313. Current information about signal transduction involved in acute and chronic regulation of AT receptors in the proximal tubule is provided.
3. 2 Ang Il receptors and points out some therapeutic considerations in patho-physiological conditions.
4. Mujais SK, Kauffman S, Katz AI. Angiotensin II binding sites in individual segments of the rat nephron. J Clin Invest 1986; 77:315-318.
5. Dulin NO, Ernsberger P, Suciu DJ, Douglas JC. Rabbit renal epithelial angiotensin II receptors. Am J Physiol 1994; 267:F776-F782.
6. 1 receptors in renal vascular smooth muscle, proximal and distal epithelial cells is more widely distributed than previously reported.
7. Terada Y, Tomita H, Nonoguchi-Marumo F. PCR localization of angiotensin II receptor and angiotensiongen mRNAs in rat kidney. Kidney Int 1993; 43:1251-1259.
8. 2 receptor binding sites in the adventitia of human kidney vasculature. Clin Exp Pharmacol Physiol 1996; 3 (Suppl):S147-S154.
9. Du Y, Yao A, Guo DF, Inagami T, Wang DH. Differential regulation of angiotensin II receptor subtypes in rat kidney by low dietary sodium. Hypertension 1995; 25:872-877.
10. Llorens-Cortes C, Greenberg B, Huang HM, Corvol P. Tissular expression and regulation of type 1 angiotensin II receptor subtypes by quantitative reverse transcriptase-polymerase chain reaction analysis. Hypertension 1994; 24:538-548.
11. Kitami Y, Okura T, Marumoto K, Wakamiya R, Hiwada K. Differential gene expression and regulation of type-1 angiotensin II receptors sub-types in the rat. Biochem Biophys Res Commun 1992; 188:446-452.
12. 1 receptor gene expression is regulated in a tissue specific manner that is different from other components of the RAS.
13. Wang DH, Du Y, Zhao H, Granger JP, Speth RC, Dipette DJ. Regulation of angiotensin type 1 receptor and its gene expression: role in renal growth. J Am Soc Nephrol 1997; 8:193-198. Blockade of renal AT1 receptors retarded normal renal growth, but increased expression of AT1 mRNA and receptor density induced by low salt diet did not increase renal growth, suggesting that an increase in renal mass above normal level requires activation of multiple factors.
14. Wang DH, Du Y, Yao A, Hu Z. Regulation of type 1 angiotensin II receptor and its subtype gene expression in kidney by sodium loading and angiotensin II infusion. J Hypertens 1996; 14:1409-1415. High salt intake downregulates AT1B mRNA expression but does not change AT1A mRNA expression or density in the kidney.
15. Makita N, Iwai N, Inagami T, Badr KF. Two distinct pathways in the down-regulation of AT-1 angiotensin II receptor gene in rat glomerular mesangial cells. Biochem Biophys Res Commun 1992; 185:142-146.
16. Cheng H-F, Becker BN, Burns KD, Harris RC. Angiotensin II regulates its receptor sites in rabbit proximal tubule. J Clin Invest 1995; 95:2012-2019.
17. Valentin JP, Sechi LA, Griffin CA, Humphreys MH, Schambelan M. The renin-angiotensin system and compensatory renal hypertrophy in the rat. Am J Hypertens 1997; 10:397-402. Compensatory renal hypertrophy after uninephrectomy occurred in the absence of measurable changes in components of the RAS, despite functionally significant inhibition of this system by captopril.
18. 1 receptor genes that modulate receptor function and altered reactivity of renal vessels to Ang II.
19. Norrelund H, Christensen KL, Samani NJ, Kimber P, Mulvany MJ, Korsgaard N. Early narrowed afferent arteriole is a contributor to the development of hypertension. Hypertension 1994; 24:301-308.
20. Skov K, Fenger-Gronj, Mulvany MJ. Effects of an angiotensin-converting enzyme inhibitor, a calcium antagonist, and an endothelin receptor antagonist on renal afferent arteriola structure. Hypertension 1996; 28:464-471. Morphometric studies of afferent arterioles in spontaneously hypertensive rats demonstrated that cilazapril increased luminal diameter and that the antihypertensive effect persisted after withdrawal of the ACE inhibitor, suggesting a pathogenic role for afferent arteriole diameter in the development of high blood pressure in spontaneously hypertensive rats.
21. Navar LG, Inscho EW, Majid DSA, Imig JD, Harrison-Bernard, Mitchell KD. Paracrine regulation of the renal micro circulation. Physiological Rev 1996; 76:425-536.
22. 2 subtype-specific angiotensin II ligands. J Pharmacol Exp Ther 1992; 262:1154-1158.
23. Price DA, DeÓliveira JM, Fisher NDL, Hollenberg NK. Renal hemodynamic response to an Angiotensin Il antagonist, Eprosartan. in healthy men. Hypertension 1997; 30:240-246. This paper provides information about hormonal and renal haemodynamics during the blockade of the RAS in normotensive individuals.
24. Mitchell KD, Navar LG. Responses of the tubuloglomerular feedback mechanisms to ACE inhibitors and angiotensin II. In: Diuretics III: chemistry, pharmacology, and clinical applications. Puschett JB, Greenburg A (editors). Amsterdam: Elsevier; 1990. pp. 764-768.
25. 1 receptor. Br J Pharmacol 1996; 119:617-618. Intratubular losartan increased fluid uptake in the proximal tubule. No effects were observed with PD123319.
26. Xie MH, Liu FY, Wong PC, Timmermans PBMWM, Cogan M. Proximal nephron and renal effects of Dup753, a non-peptide angiotensin II receptor antagonist. Kidney Int 1990; 38:473-479.
27. Ardaillou R. Some recent progress in the physiopathology of the reninangiotensin system. Kidney Curr Surv World Lit 1997; 6:91-95. Current information of RAS in gene manipulation and polymorphisms, effects on endothelial cells, vascular hypertrophy and proximal tubule is provided.
28. +-ATPase in late distal segments.
29. +-ATPase.
30. Beck F-X, Ohno A, Müller E, Seppi T, Pfaller W. Inhibition of angiotensin converting enzyme modulates structural and functional adaptation to loop diuretic-induced diuresis. Kidney Int 1997; 51:36-43. This paper provides information regarding changes in intracellular sodium concentration. The increase in sodium pump density may participate in initiation of cell adaptation of distal segments to chronic increased salt delivery. Inhibition of ACE reverses the torasemide induced increase in apparent sodium pump density in principal cells and decreases hypertrophy.
31. Wolf G, Haberstroch U, Neilson EG. Angiotensin II stimulates the proliferation and biosynthesis of type I collagen in cultured murine mesangial cells. Am J Pathol 1992; 140:95-107.
32. Ray PE, Aguilera G, Koop JB, Horikoshi S, Klotman PE. Angiotensin II receptor mediated proliferation of human fetal mesangial cells. Kidney Int 1991; 40:764-761.
33. Higueruelo S, Romero R. Angiotensin II requires PDGF-BB to induce DNA synthesis in rat mesangial cells cultured in an exogenous insulin free medium. Nephrol Dial Transplant 1997; 12:694-700. Ang II has a weak mitogenic effect on mesangial cells in conditions similar to in vivo, and requires platelet-derived growth factor or high concentrations to induce proliferation, which is reversed by losartan.
34. Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 1994; 331:1286-1292.
35. Kagami S, Border WA, Miller DE, Noble NA. Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor beta expression in rat glomerular mesangial cells. J Clin Invest 1994; 93:2431-2437.
36. Feener EP, Northrup JM, Aiello LP, King GL. Angiotensin II induces plasminogen activator inhibitor 1 and 2 expression in vascular endothelial and smooth muscle cells. J Clin Invest 1995; 95:1353-1362.
37. Baricos WH, Cortez SL, El Dahr SS, Schnaper HW. ECM extracellular matrix degradation by cultured human mesangial cells is mediated by a PA/plasmin/MMP-2 cascade. Kidney Int 1995; 47:1039-1047.
38. Kagami S, Kuhara T, Okada K, Kuroda Y, Border WA, Noble NA. Dual effects of angiotensin II and the plasminogen plasmin system in rat mesangial cells. Kidney Int 1997; 51:664-671. Ang II stimulates PAI-1 by two different mechanisms. A direct transcriptional upregulation of PAI-1 gene and another one through induction of transforming growth factor-β providing sustained changes in PAI-1/plasmin activator system, which would favour extracellular matrix accumulation by inhibiting turnover.
39. Shankland SJ, Ly H, Thai K, Scholey JW. Increased glomerular capillary pressure alters glomerular cytokine expression. Circ Res 1994; 75:844-853.
40. Oikawa T, Freeman M, Lo W, Vaughan DE, Fogo A. Modulation of plasminogen activator inhibitor-1 in vivo: a new mechanism for the antifibrotic effect of renin-angiotensin inhibition. Kidney Int 1997; 51:164-172. Inhibition of the RAS may ameliorate injury after radiation by accelerating fibrinolysis and extracellular matrix degradation, at least in part through suppression of PAI-1 expression.
41. Nishimura M, Okamura M, Konishi Y, Inoue K, Young CK, Yoshioka T, et al. Effect of treatment with ACE inhibitor on TGFbeta gene expressions in renal biopsy from patients with IgA nephropathy [abstract]. J Am Soc Neprol 1995; 6:397.
42. Ruiz-Muǹoz LM, Vidal-Vanaclocha F, Lampreabe I. Enalaprilat inhibits hydrogen peroxide production by murine mesangial cells exposed to high glucose concentrations. Nephrol Dial Transplant 1997; 12:456-464. Enalaprilat inhibits hydrogen peroxide production by mesangial cells stimulated by glucose by a protein kinase C mediated mechanisms.
43. Siragy HM, Jaffa AA, Margolis HS, Carey RM. Renin-angiotensin system modulates renal bradykinin production. Am J Physiol 1996; 271:R1090-R1095. Inhibition of renin decreased renal interstitial bradykinin and cGMP in the kidney of conscious dogs, suggesting a tonic stimulation by the RAS.
44. Largo R, Gómez-Garre D, Liu XH, Alonso J, Blanco J, Plaza JJ, Egido J. Endothelin-1 upregulation in the kidney of uninephrectomized spontaneously hypertensive rats and its modification by the angiotensin-converting enzyme inhibitor quinapril. Hypertension 1997; 29:1178-1185. Uninephrectomized spontaneously hypertensive rats had an overexpression of endothelin-1 gene and protein, which diminished with quinapril: proteinuria fell and the morphological lesions improved.