GC/MS analysis of urinary excretion of 9* 11β-PGF2 in acute and exercise-induced asthma in children

Clinical and Experimental Allergy

Volumn 28, Issue 2, 1998, Pages 181-186

  Nagakura, T ^a   Obata, T ^a   Shichijo, K ^b   Matsuda, S ^b   Sigimoto, H ^b   Yamashita, K ^c   Masaki, T ^a   Maekawa, K ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Higashisaitama National Hospital   (Japan)

^c NIPPON KAYAKU CO LTD   (Japan)

Author keywords

11 PGF2; Acute asthmatic attack; Exercise induced asthma; GC MS; Urinary 9

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CROMOGLYCATE DISODIUM; PROSTAGLANDIN F2; THEOPHYLLINE;

ALLERGIC DISEASE; ARTICLE; BRONCHOSPASM; CLINICAL ARTICLE; EXERCISE INDUCED ASTHMA; FEMALE; GAS CHROMATOGRAPHY; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MASS SPECTROMETRY; PATHOGENESIS; PRIORITY JOURNAL; SCHOOL CHILD; URINALYSIS; URINARY EXCRETION;

ACUTE DISEASE; ADOLESCENT; ASTHMA; ASTHMA, EXERCISE-INDUCED; CHILD; CHILD, PRESCHOOL; DINOPROST; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; TIME FACTORS;

EID: 0031907049     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.1998.00187.x     Document Type: Article

References (21)

1. Liston TE, Roberts LJ II. Transformation of prostaglandin D2 to 9α,11β-(15S)-trihydroxy-prosta-(5Z,13E)-dien-1-oic acid 9α,11β-prostaglandin F2): A unique biologically active prostaglandin produced enzymatically in vivo in humans. Proc Natl Acad Soc USA 1985; 82:6030-4.
2. Parsons WG III, Roberts LJ II. Transformation of prostaglandin D2 to isometric prostaglandin F2 compounds by human eosinophils. J Immunol 1988; 141:2413-9.
3. 2 in asthma. Am Rev Respir Dis 1987; 136:1140-4.
4. 2 in human urine and plasma by gas chromatography-mass spectrometry. J Chromatogr B 1994; 655:173-8.
5. Murray JJ, Tonnel AB, Brash AR et al. Release of prostaglandin D2 into human airways during acute antigen challenge. N Engl J Med 1986; 315:800-4.
6. Wood DW, Downes JJ, Lecks HI. A clinical scoring system for the diagnosis of respiratory failure. Preliminary report on childhood status asthmaticus. Am J Dis Child 1972; 123:227-8.
7. Iikura Y, Inui H, Nagakura T, Lee TH. Factors predisposing to exercise-induced late asthmatic response. J Allergy Clin Immunol 1985; 75:285-9.
8. Robinson C, Hardy CC, Holgate ST. The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men. Biochem Biophys Acta 1988; 963:151-61.
9. Awad JA, Morrow JD, Roberts LJ II. Detection of major urinary metabolite of prostaglandin D2 in the circulation: Demonstration of elevated levels in patients with disorders of systemic mast cell activation. J Allergy Clin Immunol 1994; 93:817-24.
10. 2 and its subsequent metabolism in rat, rabbit and guinea pig. Biochem Pharmacol 1988; 37:3591-9.
11. + dependent pathways. Biochem Pharmacol 1989; 38:3267-71.
12. Finnerty JP, Holgate ST. Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination. Eur Respir J 1990; 3:540-7.
13. Ahmed T, Garrigo J, Danta I. Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. N Engl J Med 1993; 329:90-5.
14. Ahmed T, Syriste T, Lucio J, Abraham WM, Robinson M, D'Brot J. Inhibition of antigen-induced airway and cutaneous responses by heparin: a pharmacodynamic study. J Appl Physiol 1993; 74:1492-8.
15. Broide DH, Eisman S, Ramsdell JW, Ferguson P, Schwartz LB, Wasserman SI. Airway levels of mast cell-derived mediators in exercise-induced asthma. Am Rev Respir Dis 1990; 141:563-9.
16. Jarjour NN, Calhoun WJ, Stevens CA, Salisbury SM. Exercise-induced asthma is not associated with mast cell activation or airway inflammation. J Allergy Clin Immunol 1992; 89:60-8.
17. Lewis RA, Austen KF, Soherman RJ. Leukotriene and other products of the 5-lipoxygenase pathway. N Engl J Med 1990; 323:645-5.
18. Smith C, Christie PE, Hawkworth RJ et al. Urinary leukotriene E4 levels after allergen and exercise challenge in bronchial asthma. Am Rev Respir Dis 1991; 144:1411-3.
19. Kikawa Y, Hosoi S, Inoue Y et al. Exercise-induced urinary excretion of leukotriene E4 in children with atopic asthma. Pediatr Res 1991; 29:455-9.
20. Manning PJ, Watson RM, Margolskee DJ et al. Inhibition of exercise-induced bronchoconstriction by MK-571, a potent leukotriene-receptor antagonist. N Engl J Med 1990; 232:1736-9.
21. Amirav I, Pawlowski N. Inhibition of exercise-induced bronchoconstriction by MK-571, a potent leukotriene D4-receptor antagonist (letter). N Engl J Med 1991; 324:1288-8.