Isolation of a toxin B-deficient mutant strain of Clostridium difficile in a case of recurrent C. difficile-associated diarrhea

Clinical Infectious Diseases

Volumn 26, Issue 2, 1998, Pages 410-412

  Cohen, Stuart H ^a   Tang, Yajarayma J ^a   Hansen, Beverly ^a   Silva Jr , Joseph ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACITRACIN; BACTERIAL DNA; CEFADROXIL; CLOSTRIDIUM DIFFICILE TOXIN B; COLESTYRAMINE; METRONIDAZOLE; VANCOMYCIN;

ADULT; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL SPORE; BACTERIUM ISOLATION; BACTERIUM MUTANT; CASE REPORT; CLOSTRIDIUM DIFFICILE; COLITIS; DIARRHEA; FECES ANALYSIS; FEMALE; HUMAN; ORAL DRUG ADMINISTRATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT DISEASE; REINFECTION; RELAPSE;

EID: 0031905323     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/516324     Document Type: Article

References (10)

1. Hatheway CL. Toxigenic Clostridia. Clin Microbiol Rev 1990;1:66-98.
2. Torres JF. Purification and characterization of toxin B from a strain of Clostridium difficile that does not produce toxin A. J Med Microbiol 1991;35:40-4.
3. Borriello SP, Wren BW, Hyde S, et al. Molecular, immunological, and biological characterization of a toxin A-negative, toxin B-positive strain of Clostridium difficile. Infect Immun 1992;60:4192-9.
4. O'Neill GL, Beaman MH, Rilley TV. Relapse versus reinfection with Clostridium difficile. Epidemiol Infect 1991;107:627-35.
5. Johnson S, Adelmann A, Clabots CR, Peterson LR, Gerding DN. Recurrences of Clostridium difficile diarrhea not caused by the original infecting organism. J Infect Dis 1989;159:340-3.
6. George WL, Sutter VL, Citron D, Finegold SM. Selective and differential medium for isolation of Clostridium difficile. J Clin Microbiol 1979;9: 214-9.
7. Gumerlock PH, Tang YJ, Weiss JB, Silva J Jr. Specific detection of toxigenic strains of Clostridium difficile in stool specimens. J Clin Microbiol 1993;31:507-11.
8. Tang YJ, Gumerlock PH, Weiss JB, Silva J Jr. Specific detection of Clostridium difficile toxin A gene sequences in clinical isolates. Mol Cell Probes 1994;8:463-7.
9. Tang YJ, Houston ST, Gumerlock PH, et al. Comparison of arbitrarily primed PCR with restriction endonuclease and immunoblot analyses for typing Clostridium difficile isolates. J Clin Microbiol 1995;33: 3169-73.
10. Riegler M, Sedivy R, Pothoulakis C, et al. Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro. J Clin Invest 1995;95:2004-11.