Neurotoxic effects of fractionated diesel exhausts following microinjections in rat hippocampus and striatum

Environmental Research

Volumn 76, Issue 1, 1998, Pages 41-51

  Andersson, Helena ^a   Lindqvist, Eva ^a   Westerholm, Roger ^b   Grägg, Kerstin ^c   Almén, Jacob ^c   Olson, Lars ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c Motortestcenter   (Sweden)

Author keywords

Acetylcholine esterase; Diesel exhausts; Diesel fuel; Glial fibrillary acidic protein; Hippocampus; Striatum; Tyrosine hydroxylase

Indexed keywords

ACETYLCHOLINESTERASE; DIESEL FUEL; GLIAL FIBRILLARY ACIDIC PROTEIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; CORPUS STRIATUM; DNA BINDING; ENZYME LOCALIZATION; EXHAUST GAS; FRACTIONATION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MICROINJECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA; VIOLA (ANGIOSPERM);

EID: 0031905265     PISSN: 00139351     EISSN: None     Source Type: Journal    
DOI: 10.1006/enrs.1997.3791     Document Type: Article

References (23)

1. Alsberg T., Stenberg U., Westerholm R., Strandell M., Rannug U., Sundvall A., Romert L., Bernson V., Pettersson B., Toftgård R., Franzén B., Jansson M., Gustafsson J.-Å., Egebäck K.-E., Tejle G. Chemical and biological characterization of organic material from gasoline exhaust particles. Environ. Sci. Technol. 19:1985;43-50.
2. Coons A. H. Fluorescent antibody methods. General Cytochemical Methods. 1958;Academic Press, New York. p. 399-422.
3. Eng L. R., Reier P. J., Houle J. D. Astrocyte activation and fibrous gliosis: Glial fibrillary acidic protein immunostaining of astrocytes following intraspinal cord grafting of fetal CNS tissue. Prog. Brain Res. 71:1987;439-455.
4. Eriksdotter-Nilsson M., Björklund H., Dahl D., Olson L. Laminin immunohistochemistry: A simple method to visualize and quantitate vascular structures in the mammalian brain. J. Neurosci. Methods. 17:1986;275-286.
5. Federal Register. 1987.
6. Jayasekara S., Sharma R. P., Drown D. B. Effects of benzo(a. Ecotoxicol. Environ. Saf. 24:1992;1-12.
7. Johnson G. D., de la Nogueira-Araujo G. M. A simple method of reducing the fading in immunofluorescence during microscopy. J. Immunol. Methods. 43:1981;349-350.
8. Löfroth G., Toftgård R., Nilsson L., Agurell E., Gustafsson J.-Å. Short-term bioassays of nitro derivatives of benzo(a)pyrene and perylene. Carcinogenesis. 5:1985;925-930.
9. Mason G., Gustafsson J.-Å., Westerholm R., Li H. Chemical fractionation of particulate extracts from diesel vehicle exhausts: Distribution of ligands for the dioxin receptor. Environ. Sci. Technol. 26:1992;1635-1638.
10. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, San Diego.
11. Pelkonen O., Nebert D. W. Metabolism of polycyclic aromatic hydrocarbons: Etiologic role in carcinogenesis. Pharmacol. Rev. 34:1982;189-222.
12. Poland A., Knutson J. C. 2,3,7,8-Tetrachlorodibenzo-p. Annu. Rev. Toxicol. Pharmacol. 22:1982;517-554.
13. Rannug U., Sundvall A. Mutagenic properties of gasoline exhausts. Environ. Int. 11:1985;303-309.
14. Rosenkrantz H. S., Mermelstein R. Mutagenicity and genotoxicity of nitroarenes. All nitro-containing chemicals were not created equal. Mutat. Res. 114:1983;217-267.
15. Sagai M., Saito H., Ichinose T., Kodama M., Mori Y. Biological effects of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in mouse. Free Radical Biol Med. 14:1993;37-47.
16. Sullivan P. D. Free radicals of benzo(a)pyrene and derivatives. Environ. Health Perspect. 64:1985;283-295.
17. Toftgård R., Löfroth G., Carlstedt-Duke J., Kurl R., Gustafsson J.-Å. Compounds in urban air compete with 2,3,7,8-tetrachlorodibenzo-p. Chem.-Biol. Interact. 46:1983;335-346.
18. Toftgård R., Franzén B., Gustafsson J.-Å., Löfroth G. Characterization of TCDD-receptor ligands present in extracts of urban particulate matter. Environ. Int. 11:1985;369-374.
19. Topp K. S., Faddis B. T., Vijayan V. K. Trauma-induced proliferation of astrocytes in the brains of young and aged rats. Glia. 2:1989;201-211.
20. Vogl G., Elstner E. F. Diesel soot particles catalyze the production of oxy-radicals. Toxicol. Lett. 47:1989;17-23.
21. Westerholm R., Alsberg T., Frommelin Å., Strandell M., Rannug U., Winquist L., Grigoriadis V., Egebäck K.-E. Effect of fuel polycyclic aromatic hydrocarbon content on the emissions of polycyclic aromatic hydrocarbons and other mutagenic substances from a gasoline-fueled automobile. Environ. Sci. Technol. 22:1988;925-930.
22. Westerholm R., Egebäck K.-E. Impact of fuels on diesel emissions: A chemical and biological characterization. 1991;Swedish Environmental Protection Agency, Report 3968, Solna.
23. Westerholm R. N., Almén J., Li H., Rannug J. U., Egebäck K.-E., Grägg K. Chemical and biological characterization of particulate-, semivolatile- and gas-phase-associated compounds in diluted heavy-duty diesel exhausts: A comparison of three different semivolatile-phase samplers. Environ. Sci. Technol. 25:1991;332-338.