Quantitative comparison of apoptosis to cell proliferation and p53 protein in breast carcinomas

Analytical and Quantitative Cytology and Histology

Volumn 20, Issue 1, 1998, Pages 1-6

  Zheng, Wei Qiang ^a,b   Zhan, Rong Zhou ^a,b  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Breast neoplasms; Mitosis; p53 protein

Indexed keywords

PROTEIN P53;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER GRADING; CELL DEATH; CELL GROWTH; CELL LOSS; CELL PROLIFERATION; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MITOSIS INDEX; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOCARCINOMA; ADULT; AGED; APOPTOSIS; BREAST NEOPLASMS; CARCINOMA; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; CELL DIVISION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; MITOTIC INDEX; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031905262     PISSN: 08846812     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Searle J, Kerr JFR, Bishop CJ: Necrosis and apoptosis: Distinct modes of cell death with fundamentally different significance. Pathol Annu 1982;17:229-2592
2. Kerr JFR, Wyllie AH, Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-257
3. Kerr JFR, Winterford CM, Harmon BV: Apoptosis: Its significance in cancer and cancer therapy. Cancer 1994;73:2013-2026
4. Majno G, Joris I: Apoptosis, oncosis, and necrosis: An overview of cell death. Am J Pathol 1995;146:3-15
5. van Diest PJ, Baak JPA: The morphometric prognostic index is the strongest prognosticator in premenopausal lymph node-negative and lymph node-positive breast cancer patients. Hum Pathol 1991;22:326-330
6. van Diest PJ, Baak JPA, Matze-Cok P, van Corp LI-IM, Kwee WS, Los J, Peterse JL, Ruitenberg HM, Schapers RFM, Schipper MEI, Somsen JG, Willig AWPM, Ariens AT: Reproducibility of mitosis counting in 2,469 breast cancer specimens: Results from the Multicenter Morphometric Mammary Carcinoma Project. Hum Pathol 1992; 23:603-607
7. Schlichtholz B, Legros Y, Gillet D, Gaillard C, Marty M, Lane D, Calvo F, Soussi T: The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot. Cancer Res 1992;52:6380-6384
8. Merlo GR, Bernardi A, Diella F, Venesio T, Cappa APM, Callahan R, Liscia DS: In primary human breast carcinomas mutations in exon 5 and 6 of the p53 gene are associated with a high S-phase index. Int J Cancer 1993;54:531-535
9. Igo R, Gatter K, Bartek J, Lane D, Harris AL: Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet 1990;335:675-679
10. Finlay CA, Hinds PW, Levine AJ: The p53 proto-oncogene can act as a suppressor of transformation. Cell 1989;57:1083-1093
11. Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC: Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992;69:119-128
12. Lowe SW, Ruley HE, Jacks T, Housman DE: p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993;74:957-967
13. Clarke AR, Gledhill S, Hooper ML, Bird CC, Wyllie AH: p53 Dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following γ-irradiation. Oncogene 1994;9:1767-1773
14. O'Leary TJ, Steffes MW: Can you count on the mitotic index? Hum Pathol 1996;27:147-151
15. Lipponen P, Ji H, Aaltomaa S, Syrjanen S, Syrjanen K: p53 Protein expression in breast cancer as related to histopathological characteristics and prognosis. Int J Cancer 1993;55:51-56
16. Aaltomas S, Lipponen P, Eskelinen M, Kosma V-M, Marin S, Alhava E, Syrjanen K: Prognostic scores combining clinical, histological and morphometric variables in assessment of the disease outcome in female breast cancer. Int J Cancer 1991;49:886-892
17. Eskelinen M, Lipponen P, Papinaho S, Aaltomaa S, Kosma V-M, Klemi P: DNA flow cytometry, nuclear morphometry, mitotic indices and steroid receptors as independent prognostic factors in female breast cancer. Int J Cancer 1992;51:555-561
18. Arends MJ, McGregor AH, Wyllie AH: Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras and HPV oncogenes. Am J Pathol 1994;144:1045-1057
19. Saegusa M, Takano Y, Wakabayashi T, Okayasu I: Apoptosis in gastric carcinomas and its association with cell proliferation differentiation. Jpn J Cancer Res 1995;86:743-748
20. Saegusa M, Takano Y, okayasa I: Bcl-2 expression and its correlation with apoptosis, p53 immunoreactivity and cell proliferation in human gastric carcinomas. J Cancer Res Clin Oncol 1995;121:357-363
21. Kasagi N, Gomyo Y, Shirai H, Tsujitani S, Ito H: Apoptotic cell death in human gastric carcinoma: Analysis by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. Jpn J Cancer Res 1994;85:939-945
22. Leoncini L, Vecchio MTD, Megha T, Barbini P, Galieni P, Pileri S, Sabaetini E, Gherlinzoni F, Tosi Kraff R, Coffier H: Correlation between apoptotic and proliferative indices in malignant non-Hodgkin's lymphomas. Am J Pathol 1993;142:755-763
23. Lane PD: A death in the life of p53. Nature 1993;362:786-787