Serotonin and aggression and the alcohol-aggression relationship

Alcohol and Alcoholism

Volumn 33, Issue 1, 1998, Pages 55-65

  Pihl, R O ^a   Lemarquand, David ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; SEROTONIN;

AGGRESSION; ALCOHOL CONSUMPTION; BEHAVIOR DISORDER; CONFERENCE PAPER; HUMAN; NONHUMAN; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; VIOLENCE;

EID: 0031904910     PISSN: 07350414     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.alcalc.a008348     Document Type: Conference Paper

References (93)

1. Abbar, M., Courtet, P., Amadeo, S., Caer, Y., Mallet, J., Baldy-Moulinier, M., Castelnau, D. and Malafosse, A. (1995) Suicidal behaviors and the tryptophan hydroxylase gene. Archives of General Psychiatry 52, 846-849.
2. Asberg, M., Träskman, L. and Thorén, P. (1976) 5-HIAA in the cerebrospinal fluid - a biochemical suicide predictor? Archives of General Psychiatry 33, 1193-1197.
3. Bailey, D. and Taylor, S. (1991) Effects of alcohol and aggressive disposition on human physical aggression. Journal of Research in Personality 25, 334-342.
4. Biggio, G., Fadda, F., Fanni, P., Tagliamonte, A. and Gessa, G. L. (1974) Rapid depletion of serum tryptophan, brain tryptophan, serotonin, and 5-hydroxyindoleacetic acid by a tryptophan-free diet. Life Sciences 14, 1321-1329.
5. Bioulac, B., Benezech, M., Renaud, B., Roche, D. and Nöel, B. (1978) Biogenic amines in 47, XYY syndrome. Neuropsychopharmacology 4, 366-370.
6. Bioulac, B., Benezech, M., Renaud, B., Nöel, B. and Roche, D. (1980) Serotoninergic dysfunction in the 47, XYY syndrome. Biological Psychiatry 15, 917-923.
7. 2 receptor binding on platelets of delinquent adolescents. Psychopharmacology 118, 354-356.
8. Brown, C. S., Kent, T. A., Bryand, S. G., Gevedon, R. M., Campbell, J. L., Felthous, A. R., Barratt, E. S. and Rose, R. M. (1989) Blood platelet uptake of serotonin in episodic aggression. Psychiatry Research 27, 5-12.
9. Brown, G. L. Goodwin, F. K., Ballenger, J. C., Goyer, P. F. and Major, L. F. (1979) Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Research 1, 131-140.
10. Brown, G. L., Ebert, M. H., Goyer, P. F., Jimerson, D. C., Klein, W. J., Bunney, W. E. and Goodwin, F. K. (1982) Aggression, suicide, and serotonin: Relationships to CSF amine metabolites. American Journal of Psychiatry 139, 741-746.
11. Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H. and van Oost, B. A. (1993) Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262, 578-580.
12. Bushman, B. J. and Cooper, H. M. (1990) Effects of alcohol on human aggression: An integrative review. Psychological Bulletin 107, 341-354.
13. Chamberlain, B., Ervin, F., Pihl, R. O. and Young, S. N. (1987) The effect of raising or lowering tryptophan levels on aggression in vervet monkeys. Pharmacology, Biochemistry and Behavior, 27, 503-510.
14. Cherek, D. R., Spiga, R. and Creson, D. L. (1995) Acute effects of eltoprazine on aggressive and point-maintained responding of normal male participants. Phase I study. Experimental and Clinical Psychopharmacology 3, 287-293.
15. Cleare, A. J. and Bond, A. J. (1995) The effect of tryptophan depletion and enhancement on subjective and behavioural aggression in normal male subjects. Psychopharmacology 118, 72-81.
16. Cocarro, E. F. (1992) Impulsive aggression and central serotonergic system function in humans: An example of a dimensional brain-behavior relationship. International Clinical Psychopharmacology 7, 3-12.
17. Cocarro, E. F., Siever, L. J., Klar, H. M., Maurer, G., Cochrane, K., Cooper, T. B., Mohs, R. C. and Davis, K. L. (1989), Serotonergic studies in patients with affective and personality disorders: Correlates with suicidal and impulsive aggressive behavior. Archives of General Psychiatry 46, 587-599.
18. Cocarro, E. F., Silverman, J. M., Klar, H. M., Horvath, T. B. and Siever, L. J. (1994). Familial correlates of reduced central serotonergic system function in patients with personality disorders. Archives of General Psychiatry 51, 318-324.
19. Cocarro, E. F., Berman, M. E., Kavoussi, R. J. and Hauger, R. L. (1996a) Relationship of prolactin response to d-fenfluramine to behavioral and questionnaire assessments of aggression in personality-disordered men. Biological Psychiatry 40, 157-164.
20. Cocarro, E. F., Kavoussi, R. J., Sheline, Y. I., Lish, J. D. and Csernansky, J. G. (1996b) Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet. Archives of General Psychiatry 53, 531-536.
21. Doudet, D. J., Hommer, D., Higley, J. D., Andreason, P. J., Moneman, R., Suomi, S. J. and Linnoila, M. (1995) Cerebral glucose metabolism, CSF5-HIAA levels, and aggressive behavior in Rhesus monkeys. American Journal of Psychiatry 152, 1782-1787.
22. Fernstrom, J. D. and Wurtman, R. J. (1974) Brain serotonin content: Physiological dependence on plasma tryptophan levels. Science 173, 149-152.
23. Finn, P. R., Young, S. N., Pihl, R. O. and Ervin, F. R. (1997) The effects of acute plasma tryptophan manipulation on hostile mood: The influence of trait hostility. Aggressive Behavior, in press.
24. Fishbein, D. H., Lozovsky, D. and Jaffe, J. H. (1989) Impulsivity, aggression, and neuroendocrine responses to serotonergic stimulation in substance abusers. Biological Psychiatry 25, 1049-1066.
25. Gessa, G., Muntone, F., Collu, M., Vargiu, L. and Mereu, G. (1985) Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Research 348, 201-203.
26. Gessa, G. L., Biggio, G., Fadda, F., Corsini, G. V. and Tagliamonte, A. (1974) Effect of the oral administration of tryptophan-free amino acid mixtures on serum tryptophan, brain tryptophan and serotonin metabolism. Journal of Neurochemislry 22, 869-870.
27. Halperin, J. M., Sharma, V., Siever, L. J., Schwartz, S. T., Matier, K., Wornell, G. and Newcorn, J. H. (1994) Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. American Journal of Psychiatry 151, 243-248.
28. Higley, J. D., Mehlman, P. T., Taub, D. M., Higley, S. B., Suomi, S. J., Linnoila, M. and Vickers, J. H. (1992) Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. Archives of General Psychiatry 49, 436-441.
29. Higley, J. D., Suomi, S. J. and Linnoila, M. (1996a) A nonhuman primate model of type II excessive alcohol consumption? Part 2. Diminished social competence and excessive aggression correlates with low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations. Alcoholism: Clinical and Experimental Research 20, 643-650.
30. Higley, J. D., Mehlman, P. T., Higley, S. B., Fernald, B., Vickers, J., Lindell, S. G., Taub, D. M., Suomi, S. J. and Linnoila, M. (1996b) Excessive mortality in young free-ranging male nonhuman primates with low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations. Archives of General Psychiatry 53, 537-543.
31. Higley, J. D., King, S. T. Jr, Hasert, M. F., Champoux, M., Suomi, S. J. and Linnoila, M. (1996c) Stability of interindividual differences in serotonin function and its relationship to severe aggression and competent social behavior in rhesus Macaque females. Neuropsychopharmacology 7, 67-76.
32. 1b receptor in the pressure-induced behavioral and neurochemical disorders in rats. Pharmacology, Biochemistry and Behavior 53, 257-264.
33. Kruesi, M. J., Rapoport, J. L., Hamburger, S., Hibbs, E., Potter, W. Z., Lenane, M. and Brown, G. L. (1990) Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Archives of General Psychiatry 47, 419-426.
34. Kruesi, M. J. P., Hibbs, E. D., Zahn, T. P., Keysor, C. S., Hamburger, S. D., Bartko, J. J. and Rapoport, J. L. (1992) A 2-year prospective followup study of children and adolescents with disruptive behavior disorders. Archives of General Psychiatry 49, 429-435.
35. Lau, M., Pihl, R. and Peterson, J. (1995) Aggression, cognitive performances, acute alcohol intoxication and provocation. Journal of Abnormal Psychiatry 104, 150-155.
36. LeMarquand, D., Pihl, R. O. and Benkelfat, C. (1994a) Serotonin and alcohol intake, abuse and dependence: Clinical evidence. Biological Psychiatry 36, 326-337.
37. LeMarquand, D., Pihl, R. O. and Benkelfat, C. (1994b) Serotonin and alcohol intake, abuse and dependence: Findings of animal studies. Biological Psychiatry 36, 395-421.
38. LeMarquand, D., Pihl, R. O., Benkelfat, C., Young, S., Tremblay, R. and Palmour, R. (1998) Tryptophan depletion, aggression and behavioral disinhibition in individuals at risk for future psychopathology. In Unlocking Crime: The Biosocial Key, Raine, A., Farrington, D., Brennan, P. and Mednick, S., eds, Plenum Press, New York, in press.
39. Lidberg, L., Asberg, M. and Sunquist-Stensman, U. B. (1984) 5-Hydroxyindoleacetic acid levels in attempted suicides who have killed their children. Lancet ii, 928.
40. Lidberg, L., Tuck, J. R., Asberg, M., Scalia-Tomba, G. P. and Bertilsson, L. (1985) Homicide, suicide and CSF 5-HIAA. Acta Psychiatrica Scandinavica 71, 230-236.
41. Limson, R., Goldman, D., Roy, A., Lamparski, D., Ravitz, B., Adinoff, B. and Linnoila, M. (1991) Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls. Archives of General Psychiatry 48, 437-441.
42. Linnoila, M., Virkkunen, M., Scheinin, M., Nuutila, A., Rimon, R. and Goodwin, F. K. (1983) Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sciences 33, 2609-2614.
43. Linnoila, M., De Jong, J., and Virkkunen, M. (1989) Family history of alcoholism in violent offenders and impulsive fire starters. Archives of General Psychiatry 46, 613-616.
44. Lopez-Ibor, J. J., Jr, Lana, F. and Saiz, J. (1991) Serotonin, impulsiveness and aggression in humans. In Serotonin-related Psychiatric Syndromes: Clinical and Therapeutic Links, Cassano, G. B. and Akiskal, H. S. eds, pp. 35-40. Royal Society of Medicine Services, London.
45. MacAndrew, C. and Edgerton, R. (1969) Drunken Comportment: A Social Explanation. Aldine, Chicago.
46. Maes, M., Scharpé, S., Verkerk, R., D'Hondt, P., Peeters, D., Cosyns, P., Thompson, P., De Meyer, F., Wauters, A. and Neels, H. (1995) Seasonal variation in plasma L-tryptophan availability in healthy volunteers. Archives of General Psychiatry 52, 937-946.
47. Marazziti, D., Rotondo, A., Presta, S., Pancioli-Guadagnucci, M. L., Palego, L. and Conti, L. (1993) Role of serotonin in human aggressive behaviour. Aggressive Behaviour 19, 347-353.
48. Mehlman, P. T., Higley, J. D., Faucher, I., Lilly, A. A., Taub, D. M., Vickers, J., Suomi, S. J. and Linnoila, M. (1994) Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. American Journal of Psychiatry 151, 1485-1491.
49. Mehlman, P. T., Higley, J. D., Faucher, I., Lilly, A. A., Taub, D. M., Vickers, J., Suomi, S. J. and Linnoila, M. (1995) Correlation of CSF 5-HIAA concentration with sociality and the timing of emigration in free-ranging primates. American Journal of Psychiatry 152, 907-913.
50. Modai, I., Apter, A., Meltzer, H. et al. (1989) Serotonin uptake by platelets of suicidal and aggressive adolescent psychiatric inpatients. Neuropsychobiology 21, 9-13.
51. Moeller, F. G., Dougherty, D. M., Swann, A. C., Collins, D., Davis, C. M. and Cherek, D. R. (1996) Tryptophan depletion and aggressive responding in healthy males. Psychopharmacology 126, 97-103.
52. Moja, E. A., Cipolla, P., Castoldi, D. and Tofanetti, O. (1989) Dose-response decrease in plasma tryptophan and in brain tryptophan and serotonin after tryptophan-free amino acid mixtures. Life Sciences 44, 971-976.
53. Moss, H. B., Yao, J. K. and Panzak, G. L. (1990) Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse. Biological Psychiatry 28, 325-338.
54. Murdoch, D., Pihl, R. O. and Ross, D. (1990) Alcohol and crimes of violence: Present issues. International Journal of Addictions 25, 1059-1075.
55. Nielsen, D. A., Goldman, D., Virkkunen, M., Tokola, R., Rawlings, R. and Linnoila, M. (1994) Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Archives of General Psychiatry 51, 34-38.
56. Nielsen, D. A., Goldman, D., Virkkunen, M., Tokola, R., Rawlings, R. and Linnoila, M. (1996) TPH replication study: Not! Archives of General Psychiatry 53, 964-965.
57. Nishizawa, S., Benkelfat, C., Young, S., Leyton, M., Mzengeza, S., de Montigny, C., Blier, P. and Diksic, M. (1997) Differences between males and females in rate of serotonin synthesis in human brain. Proceedings of the National Academy of Sciences of the USA 94, 5308-5313.
58. O'Keane, V., Moloney, E., O'Neill, H., O'Conner, A., Smith, C. and Dinan, T. G. (1992) Blunted prolactin responses to D-fenfluramine in sociopathy: Evidence for subsensitivity of central serotonergic function. British Journal of Psychiatry 160, 643-646.
59. Park, S. B., Coull, J., McShane, R., Young, A., Sahakian, B., Robbins, T. and Cowen, P. (1994) Tryptophan depletion in normal volunteers produces selective impairments in learning and memory. Neuropharmacology 33, 575-588.
60. Peterson, J., Rothfleish, J., Zelazo, P. and Pihl, R. (1990) Acute alcohol intoxication and neuropsychological functioning. Journal of Studies in Alcohol 51, 114-122.
61. Pihl, R. and Peterson, J. (1995) Alcoholism: the role of different motivational systems. Journal of Psychiatry and Neuroscience 20, 372-376.
62. Pihl, R. O., Young, S. N., Harden, P., Plotnick, S., Chamberlain, B. and Ervin, F. R. (1995) Acute effect of altered tryptophan levels and alcohol on aggression in normal human males. Psychopharmacology 119, 353-360.
63. Pihl, R., Lau, M. and Assaad, J. M. (1997) Aggressive disposition, alcohol and asgression. Aggressive Behavior 23, 11-18.
64. 2A) receptor characteristics and parenting factors for boys at risk for delinquency: A preliminary report. American Journal of Psychiatry 153, 538-544.
65. Pohorecky, L. A. (1991) Stress and alcohol interaction: An update of human research. Alcoholism: Clinical and Experimental Research 15, 438-459.
66. Poulos, C. X., Parker, J. L. and Le, A. D. (1998) Serotonergic modulation of impulsivity in a delay-of-reward paradigm: Evidence for a linkage with alcohol consumption. Behavioral Pharmacology in press.
67. Pucilowski, O. and Kostowski, J. (1980) Aggressive behavior and the central serotonergic system. Behavioral Brain Research 9, 33-48.
68. Raleigh, M. J., McGuire, M. T., Brammer, G. L. and Yuwiler, A. (1984) Social and environmental influences on blood serotonin concentrations in monkeys. Archives of General Psychiatry 41, 405-410.
69. Roy, A., Adinoff, B. and Linnoila, M. (1988) Acting out hostility in normal volunteers: Negative correlation with levels of 5HIAA in cerebrospinal fluid. Psychiatry Research 24, 187-194.
70. Rydin, B., Schalling, D. and Asberg, M. (1982) Rorschach ratings in depressed and suicidal patients with low levels of 5-hydroxyindoleacetic acid in cerebrospinal fluid. Psychiatry Research 7, 229-243.
71. Salomon, R. M., Mazure, C. M. Delgado, P. L., Mendia, P. and Charney, D. S. (1994) Serotonin function in aggression: The effects of acute plasma tryptophan depletion in aggressive patients. Biological Psychiatry 35, 570-572.
72. 1B receptor. Science 265, 1875-1878.
73. Siever, L. J., Coccaro, E. J., Zemishlany, Z., Silverman, J., Klar, H., Losonczy, M. F., Davidson, M., Friedman, R., Mohs, R. C. and Davis, K. L. (1987) Psychobiology of personality disorders: Pharmacologic implications. Psychopharmacology Bulletin 23, 333-335.
74. Smith, S. E., Pihl, R. O., Young, S. N. and Ervin, F. R. (1987) Elevation and reduction of plasma tryptophan and their effects on aggression and perceptual sensitivity in normal males. Aggressive Behavior 12, 393-407.
75. Soubrié, P. (1986) Reconciling the role of central serotonin neurons in human and animal behavior. Behavioral Brain Science 9, 319-364.
76. Spoont, M. R. (1992) Modulatory role of serotonin in neural information processing: Implications for human psychopatholoay. Psychological Bulletin 112, 330-350.
77. Stoff, D. M. Pollock, L., Vetiello, B. et al. (1987) Reduction of [3H]-imipramine binding sites on platelets of conduct-disordered children. Neuropsychopharmacology 1, 55-62.
78. Stoff, D. M., Pasatiempo, A. P., Yeung, J., Cooper, T. B., Bridger, W. H, and Rabinovich, H. (1992) Neuroendocrine responses to challenge with dl-fenfluramine and aggression in disruptive behavior disorders of children and adolescents. Psychiatry Research 43, 263-276.
79. 1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH DPAT) increase in ethanol intake. Psychopharmacology 115, 173-179.
80. Traskman-Bendz, L., Asberg, M. and Schalling, D. (1986) Serotonergic function and suicidal behavior in personality disorders. Annals of the New York Academy of Sciences 487, 168-174.
81. Tuinier, S., Verhoeven, W. M. A. and van Praag, H. M. (1995) Cerebrospinal fluid 5-hydroxyindoleacetic acid and aggression: A critical reappraisal of the clinical data. International Clinical Psychopharmacology 10, 147-156.
82. van Praag, H. M. (1983) CSF 5-HIAA and suicide in non-depressed schizophrenics. Lancet ii, 977-978.
83. Virkkunen, M. and Linnoila, M. (1993) Brain serotonin, Type II alcoholism, and impulsive violence. Journal of Studies on Alcohol 54 (Suppl. 11), 163-169.
84. Virkkunen, M., Nuutila, A., Goodwin, F. K. and Linnoila, M. (1987) Cerebrospinal fluid monoamine metabolite levels in male arsonists. Archives of General Psychiatry 44, 241-247.
85. Virkkunen, M., De Jong, J., Bartko, J., Goodwin, F. K. and Linnoila, M. (1989a) Relationship of psychobiological variables to recidivism in violent offenders and impulsive fire setters. Archives of General Psychiatry 46, 600-603.
86. Virkkunen, M., De Jong, J., Bartko, J. and Linnoila, M. (1989b) Psychobiological concomitants of history of suicide attempts among violent offenders and impulsive fire setters. Archives of General Psychiatry 46, 604-606.
87. Virkkunen, M., Rawlings, R., Tokola, R., Poland, R. E., Guidotti, A., Nemeroff, C., Bissette, G., Kalogeras, K., Karonen, S.-L. and Linnoila, M. (1994a) CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic violent offenders, fire setters, and healthy volunteers. Archives of General Psychiatry 51, 20-27.
88. Virkkunen, M., Kallio, E., Rawlings, R., Tokola, R., Poland, R. E., Guidotti, A., Nemeroff, C., Bissette, G., Kalogeras, K., Karonen, S.-L. and Linnoila, M. (1994b) Personality profiles and state aggressiveness in Finnish alcoholic, violent offenders, fire setters, and healthy volunteers. Archives of General Psychiatry 51, 28-33.
89. Virkkunen, M., Eggert, M., Rawlings, R. and Linnoila, M. (1996) A prospective followup study of alcoholic violent offenders and fire setters. Archives of General Psychiatry 53, 523-529.
90. Weltzler, S., Kahn, R. S., Asnis, G. M., Korn, M. and van Praag, H. M. (1991), Serotonin receptor sensitivity and aggression. Psychiatry Research 37, 271-279.
91. White, H., Bruck, J., and Hansell, S. (1993) A longitudinal investigation of alcohol use and aggression in adolescence. Journal of Studies on Alcohol 11, 62-77.
92. Young, S. N., Pihl, R. O. and Ervin, F. R. (1988) The effect of altered tryptophan levels on mood and behaviour in normal human males. Clinical Neuropharmacology 11 (Suppl. 1), S207-S215.
93. Young, S. N., Ervin, F. R., Pihl, R. O. and Finn, P. (1989) Biochemical aspects of tryptophan deletion in primates. Psychopharmacology 98, 508-511.