Pathologic tumor response in the breast following neoadjuvant chemotherapy predicts axillary lymph node status

Cancer Journal from Scientific American

Volumn 4, Issue 4, 1998, Pages 230-236

  Kuerer, H M ^a   Newman, L A ^a   Buzdar, A U ^a   Dhingra, K ^a   Hunt, K K ^a   Buchholz, T A ^a   Binkley, S M ^a   Strom, E A ^a   Ames, F C ^a   Ross, M I ^a   Feig, B W ^a   McNeese, M D ^a   Hortobagyi, G N ^a   Singletary, S Eva ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Axillary lymph node dissection; Large primary breast cancer; Locally advanced breast cancer; Neoadjuvant chemotherapy

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUOROURACIL;

ADULT; ADVANCED CANCER; ARTICLE; AXILLARY LYMPH NODE; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CLINICAL TRIAL; CONTROLLED STUDY; DRUG RESPONSE; FEMALE; HUMAN; LYMPH NODE DISSECTION; MAJOR CLINICAL STUDY; MASTECTOMY; PRIORITY JOURNAL;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CHEMOTHERAPY, ADJUVANT; FEMALE; HUMANS; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; MASTECTOMY, SEGMENTAL; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 0031904704     PISSN: 10814442     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Delena M, Zucali R, Viganotti G, et al.Combined chemotherapy-radiotherapy approach in locally advanced (T3b-T4) breast cancer. Cancer Chemother Pharmacol 1978;1:53-59.
2. Hortobagyi GN, Blumenschein GR, Spanos W et al. Multimodal treatment of locoregionally advanced breast cancer. Cancer 1983;51:763-768.
3. Lippman ME, Sorace RA, Bagley CS et al. Treatment of locally advanced breast cancer using primary induction chemotherapy with hormonal synchronization followed by radiation therapy with or without debulking surgery. NCI Monogr 1986;1:156-159.
4. Perloff M, Lesnick GJ, Korzun A et al. Combination chemotherapy with mastectomy or radiotherapy for stage III breast carcinoma: a cancer and leukemia group B study. J Clin Oncol 1988;6:261-269.
5. Hortobagyi GN, Ames FC, Buzdar et al. Management of stage III breast cancer with primary chemotherapy, surgery, and radiation therapy. Cancer 1988;62:2507-2516.
6. Jacquillat CL, Baillet F, Weil M et al. Results of conservative treatment combining induction (neoadjuvant) and consolidation chemotherapy, hormonotherapy, and external and interstitial irradiation in 98 patients with locally advanced breast cancer (IIIA-IIIB). Cancer 1988;61:1977-1982.
7. Singletary SE, McNeese MD, Hortobagyi GN. Feasability of breast-conservation surgery after induction chemotherapy for locally advanced breast carcinoma. Cancer 1992;69:2849-2852.
8. Scholl SM, Fourquet A, Asselain B et al. Neoadjuvant versus adjuvant chemotherapy in premenopausal patients with tumours considered too large for breast conserving surgery: preliminary results of a randomised trial: S6. Eur J Cancer 1994;5:645-652.
9. Fisher B, Slack NH, Bross ID. Cancer of the breast: size of neoplasm and prognosis. Cancer 1969;5:1071-1080.
10. Fisher B, Wolmark N, Bauer M et al. The accuracy of clinical nodal staging and of limited axillary dissection as a determinant of histologic nodal status in carcinoma of the breast. Surg Gynecol Obstet 198;152:763-772.
11. McCready DR, Hortobagyi GN, Kau SW et al. The prognostic significance of lymph node metastases after preoperative chemotherapy for locally advanced breast cancer. Arch Surg 1989; 124:21-25.
12. Bruneton JN, Caramella E, Hery M et al. Axillary lymph node metastases in breast cancer preoperative detection with US. Radiology 1986;158:325-326.
13. Dhingra K, Singletary E, Strom E et al. Randomized trial of G-CSF (filgrastim)-supported dose-intensive neoadjuvant chemotherapy in locally advanced breast cancer. Proc Am Soc Clin Oncol 1995;14:94.
14. American Joint Committee on Cancer: Manual for Staging of Cancer, (4th ed.). Philadelphia: JB Lippincott, 1993:149.
15. Hunt KK, Ames FC, Singletary SE et al. Locally advanced noninflammatory breast cancer. Surg Clin North Am 1996;76:393-410.
16. Landis SH, Murray T, Bolden S et al. Cancer Statistics, 1998. CA Cancer J Clin 1998;48:6-29.
17. Delena M, Varini M, Zucali R et al. Multimodal treatment for locally advanced breast cancer. Cancer Clin Trials 1981;4:229-236.
18. Bonnadonna G, Valagussa P, Zambetti M et al. Primary chemotherapy to avoid mastectomy in tumors with diameters of three centimeters or more. J Natl Cancer Inst 1990;82:1539-1545.
19. Schwartz GF, Birchansky CA, Komarnicky LT et al. Induction chemotherapy followed by breast conservation for locally advanced carcinoma of the breast. Cancer 1994;73:362-369.
20. Brain E, Garrino C, Misset JL et al. Long-term prognostic and predictive factors in 107 stage II/III breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy. Br J Cancer 1997;1360-1367.
21. Powels TJ, Hickish TF, Makris A et al. Randomized trial of chemoendocrine therapy started before or after surgery for treatment of primary breast cancer. J Clin Oncol 1995;13:547-552.
22. Fisher B, Redmond, C, Fisher ER et al. Ten-year results of a randomized clinical trial comparing radical mastectomy and total mastectomy with or without radiation. N Engl J Med 1985;312:674-681.
23. Swain SM, Sorace RA, Bagley CS et al. Neoadjuvant chemotherapy in the combined modality approach of locally advanced nonmetastatic breast cancer. Cancer Res 1987;47:3889-3894.
24. Abraham DC, Jones RC, Jones SE et al. Evaluation of neoadjuvant chemotherapeutic response of locally advanced breast cancer by magnetic resonance imaging. Cancer 1996;78:91-100.
25. Giuliano AE, Dale PS, Turner RR et al. Improved axillary staging of breast cancer with sentinel lymphadenectomy. Ann Surg 1995;222:394-401.
26. Veronesi U, Paganelli G, Galimberti V et al. Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes. Lancet 1997;349:1864-1867.