S100B: Pathogenetic and pathophysiological implications in neurology;S100B: Pathogenetische und pathophysiologische bedeutung in der neurologie

Nervenarzt

Volumn 69, Issue 8, 1998, Pages 639-646

  Schmidt, S ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Dementia; Down syndrome; Multiple sclerosis; S100B

Indexed keywords

CALMODULIN; PROTEIN S 100; TROPONIN;

ALLERGIC ENCEPHALOMYELITIS; ALZHEIMER DISEASE; CELL DIFFERENTIATION; CELL GROWTH; CELL METABOLISM; CELL SHAPE; DOWN SYNDROME; ENERGY METABOLISM; HUMAN; MULTIPLE SCLEROSIS; NEUROLOGY; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; REVIEW;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMALS; AUTOANTIBODIES; CALCIUM-BINDING PROTEINS; CENTRAL NERVOUS SYSTEM; CHROMOSOME MAPPING; DOWN SYNDROME; HUMANS; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; NERVE GROWTH FACTORS; S100 PROTEINS;

EID: 0031904263     PISSN: 00282804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001150050323     Document Type: Review

References (94)

1. Allore R, OíHanlon D, Price R, Neilson K, Willard HF, Cox DR, Marks A, Dunn RJ (1988) Gene encoding the β subunit of S100 protein is on chromosome 21: implications for Down syndrome. Science 239:1311-1313
2. Allore RJ, Friend WC, OíHanlon D, Neilson KM, Baumal R, Dunn RJ, Marks A (1990) Cloning and expression of the human S100β gene. J Biol Chem 265:15537-15543
3. Azmitia EC, Dolan K, Whitaker-Azmitia PM (1990) S-100B but not NGF, EGF, insulin or calmodulin is a serotonergic growth factor. Brain Res 516:354-356
4. Azmitia EC, Griffin WS, Marshak DR, Van Eldik LJ, Whitaker-Azmitia PM (1992) S100 beta and serotonin: a possible astrocytic-neuronal link to neuropathology of Alzheimeris disease. Prog Brain Res 94:459-473
5. Bamford CR, Ganley JP, Sibley WA, Laguna JF (1978) Uveitis, perivenous sheathing and multiple sclerosis. Neurology 28:119-124
6. Barger SW, Van Eldik U (1992) S100β stimulates calcium fluxes in neuronal and glial cells. J Biol Chem 267:9689-9694
7. Barger SW, Van Eldik LJ, Mattson MP (1995) S100β protects hippocampal neurons from damage induced by glucose deprivation. Brain Res 677:167-170
8. Barger SW, Wolchok SR, Van Eldik LJ (1992) Disulfide-linked S100β-dimers and signal transduction. Biochim Biophys Acta 1160:105-112
9. Battacharyya A, Oppenheim RW, Prevette D, Moore BW, Brackenbury BW, Ratner N (1992) S100 is present in developing chicken neurons and Schwann cells and promotes motor neuron survival in vivo. J Neurobiol 23:451-456
10. 2+-calmodulin-dependent protein kinase II. J Biol Chem 263:5876-5883
11. Baudier J, Delphin C, Grunwald D, Khochbin S, Lawrence JJ (1992) Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b binding protein. Proc Natl Acad Sci 89:11627-11631
12. Becker LE, Mito T, Takashima S, Onodera K, Friend WC (1993) Association of phenotypic abnormalities of Down syndrome with an imbalance of genes on chromosome 21. APMIS [Suppl] 40:57-70
13. Burmeister M, Kim S, Price ER, de Lange T, Tantravahi U, Myers RM, Cox DR (1991) A map of the distal region of the long arm of human chromosome 21 constructed by radiation hybrid mapping and pulsed-field gel electrophoresis. Genomics 9:19-30
14. Donate R (1986) S-100 Proteins. Cell Calcium 7:123-145
15. Duncan AMV, Higgins J, Dunn RJ, Allore R, Marks A (1989) Redefined sublocalization of the gene encoding the β subunit of the S-100 protein (S-100B) and confirmation of a subtle t(9;21) translocation using in situ hybridization. Cytogenet Cell Genet 50:234-235
16. Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW (1993) Six S100 genes are clustered on human chromosome 1q21: identification of two previously unreported calcium-binding proteins S100D and S100E. Proc Natl Acad Sci 90:6547-6551
17. Epstein CJ (1987) The consequences of altered gene dosage in trisomy 21. In: Pueschel SM, Tingey C, Rynders JE, Crocker AC, Crutcher DM (eds) Brooks, Baltimore, pp 69-80
18. Frederickson RCA (1992) Astroglia in Alzheimeris disease. Neurobiol Aging 13:239-253
19. Friend WC, Clapoff S, Landry C, Becker LE, OíHanlon D, Allore RJ, Brown IR, Marks A, Roder J, Dunn RJ (1992) Cell-specific expression of high levels of human S100β in transgenic mouse brain in dependent on gene dosage. J Neurosci 12:4337-4346
20. Gaynor R, Irie R, Morton D, Herschman HR (1980) S100 protein is present in cultured human malignant melanomas. Nature 286:400-401
21. Gerlai R, Friend W, Becker L, OíHanlon D, Marks A, Roden J (1993) Female transgenic mice carrying multiple copies of the human gene for S100β are hyperactive. Behav Brain Res 55:51-59
22. Gerlai R, Roder J (1995) Abnormal exploratory behaviour in transgenic mice carrying multiple copies of the human gene for S100 beta. J Psychiatry Neurosci 20:105-112
23. Gerlai R, Roder J (1996) Spatial and nonspatial learning in mice: effects of S100 beta overexpression and age. Neurobiol Learn Mem 66:143-154
24. Gerlai R, Marks A, Roder J (1994) T-maze spontaneous alternation rate is decreased in S100 beta transgenic mice. Behav Neurosci 108:100-106
25. Gerlai R, Roder J (1993) Female specific hyperactivity in S100 beta transgenic mice does not habituate in open-field. Behav Brain Res 59:119-124
26. Goodison KL, Parhad IM, White CL, Sima AA, Clark AW (1993) Neuronal and glial gene expression in neocortex of Downis syndrome and Alzheimeris disease. J Neuropathol Exp Neurol 52:192-198
27. Griffin WST, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, Araoz C (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci 86:7611-7615
28. Guo HB, Stoffel-Wagner B, Bierwirth T, Mezger J, Klingmüller D (1995) Clinical significance of serum S100 in metastatic malignant melanoma. Eur J Cancer 31:924-928
29. Harder T, Kube E, Gerke V (1992) Cloning and characterization of the human gene encoding p11: structural similarity to other member of the S-100 gene family. Gene 113:269-274
30. Hassold TJ, Jacobs PS (1984) Trisomy in man. Annu Rev Genet 18:69-87
31. Hohlfeld R, Meinl E, Weber F, Zipp F, Schmidts, Sotgiu S, Goebels N, Voltz R, Spuler S, Iglesias A, Wekerle H (1995) The role of autoimmune T lymphocytes in the pathogenesis of multiple sclerosis. Neurology 45 [Suppl 6]:S33-S38
32. Howard A, Legon S, Spurr NK, Walters JRF (1992) Molecular cloning and chromosomal assignement of human calbindin-D9K. Biochem Biophys Res Commun 185:663-669
33. Ishikawa H, Nogami H, Shirasawa N (1983) Novel clonal strains from adult rat anterior pituitary producing S-100 protein. Nature 303:711-713
34. Isobe T, Okuyama T (1978) The amino-acid sequence of S-100 protein (PAP 1-b) and its relationship to calcium-binding proteins. Eur J Biochem 89:379-388
35. Isobe T, Okuyama T (1981) The amino-acid sequence of the a subunit in bovine brain S-100 protein. Eur J Biochem 116:79-86
36. Isobe T, Ishioka N, Okuyama T (1981) Structural relation of two S-100 proteins in bovine brain; subunit composition of S-100a protein. Eur J Biochem 115:469-474
37. Jensen R, Marshak DR, Anderson C, Lukas TJ, Watterson DM (1985) Characterization of human brain S100 protein fraction: amino acid sequence of S100β. J Neurochem 45:700-705
38. Jorgensen OS, Brooksbank BW, Balazs R (1990) Neuronal plasticity and astrocytic reaction in Down syndrome and Alzheimer disease. J Neurol Sci 98:63-79
39. Kato K, Kimura S (1985) S100 ao(αα) protein is mainly located in the heart and striated muscles. Biochim Biophys Acta 842:146-150
40. 2+ dependent phospholipid- (and membrane-) binding proteins. Biochem 27:6645-6653
41. Kligman D, Hsieh LS (1987) Neurite extension factor induces rapid morphological differentiation of mouse neuroblastoma cells in defined medium. Dev Brain Res 33:296-300
42. Kligman D, Marshak DR (1985) Purification and characterization of a neurite extension factor from bovine brain. Proc Natl Acad Sci 82:7136-7139
43. Kojima K, Berger T, Lassmann H, Hinze-Selch D, Zhang Y, Gehrmann J, Wekerle H, Linington C (1994) Experimental autoimmune panencephalitis and uveoretinitis in the Lewis rat transferred by T lymphocytes specific for the S100b molecule, a calcium binding protein of astroglia. J Exp Med 180:817-829
44. Kondo H, Takahashi H, Takahashi Y (1984) Immunohistochemical study of S-100 protein in the postnatal development of Müller cells and astrocytes in the rat retina. Cell Tissue Res 238:503-508
45. Kuwano R, Usui H, Maeda T, Fukiu T, Yamanari N, Ohtsuka E, Ikehara M, Takahashi Y (1984) Molecular cloning and the complete nucleotide sequence of cDNA for S-100 protein of rat brain. Nucl Acid Res 12:7455-7465
46. Kuwano R, Usui H, Maeda T, Araki K, Yamakuni T, Kurihara T, Takahashi Y (1987) Tissue distribution of rat S-100α and β subunit mRNAs. Mol Brain Res 2:79-82
47. Lakshmi MS, Parker C, Sherbet GV (1993) Metastasis associated MTS1 and NM23 genes affect tubulin polymerisation in B16 melanomas: a possible mechanism of their regulation of metastatic behavior of tumors. Anticancer Res 13:299-304
48. Lamers KJB, Van Engelen BGM, Gabreels FJM, Hommes OR, Borm GF, Wevers RA (1995) Cerebrospinal neuron-specific enolase, S-100 and myelin basic protein in neurological disorders. Acta Neurol Scand 92:247-251
49. Lassmann H (1983) Comparative neuropathology of chronic experimental allergic encephalomyelitis and multiple sclerosis. Springer, Berlin Heidelberg New York
50. Lassmann H, Vass K (1995) Are current immunological concepts of multiple sclerosis reflected by the immunopatholgy of its lesions? Springer Semin Immunopathol 17:77-87
51. Lee SW, Tomasetto C, Swisshelm K, Keyomarsi K, Sager R (1992) Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment. Proc Natl Acad Sci 89:2504-2508
52. Lightman S, McDonald WI, Bird AC, Francis DA, Hoskins A, Batchelor JR, Halliday AM (1987) Retinal nervous sheathing in optic neuritis. Its significance for the pathogenesis of multiple sclerosis. Brain 110:405-414
53. Maeda T, Usui H, Araki K, Kuwano R, Takahashi Y, Suzuki Y (1991) Structure and expression of rat-S100β subunit gene. Mol Brain Res 10:193-202
54. Markesbery WR (1992) Alzheimer's disease. In: Asbury AK, McKhann GM, McDonald WI (eds) Diseases of the nervous system, 2nd ed. Saunders, Philadelphia London Toronto pp 795-803
55. Marks A, Allore RJ (1990) S-100 protein and Down syndrome. Bioessays 12:381-383
56. Marks A, Law J, Mahony JB, Baumal R (1983) The structural conservation of S-100 protein during evolution: analysis by reactivity with a monoclonal antibody. J Neurochem 41: 107-112
57. Marks A, Petsche D, OíHanlon D, Kwong PC, Stead R Dunn R, Baumal R, Liao SK (1990) S-100 protein expression in human melanoma cells: comparison of levels of expression among different cell lines and individual cells in different phases of the cell cycle. Exp Cell Res 187:59-64
58. Marks A, OíHanlon D, Lei M, Percy ME, Becker LE (1996) Accumulation of S100 beta mRNA and protein in cerebellum during infancy in Down syndrome and control subjects. Brain Res Mol Brain Res 36:343-348
59. Marshak DR (1990) S100β as a neurotrophic factor. Prog Brain Res 86:169-181
60. Marshak DR, Peese SA, Stanley LC, Griffin WST (1991) Increased S100β neurotrophic activity in Alzheimeris disease temporal lobe. Neurobiol Aging 13:1-7
61. Martin R, McFarland F, McFarlin DE (1992) Immunological aspects of demyelinating diseases. Annu Rev Immunol 153-187
62. Mito T, Becker LE (1993) Developmental changes of S-100 protein and glial fibrillary acidic protein in the brain in Down syndrome. Exp Neurol 120:170-176
63. Mokuno K, Kato K, Kawai K, Matsuoka Y, Yanagi T, Sobuel (1983) Neuron-specificenolase and S-100 protein levels in cerebrospinal fluid of patients with various neurological diseases. J Neurol Sci 60:443-451
64. Mokuno K, Kiyosawa K, Sugimura K, Yasuda T, Riku S, Murayama T, Yanagi T, Takahashi A, Kato K (1994) Prognosticvalue of cerebrospinal fluid neuron-specific enolase and S-100b protein in Guillain-Barré syndrome. Acta Neurol Scand 89:27-30
65. Moore B (1965) A soluble protein characteristic of the nervous system. Biochem Biophys Res Commun 120:170-176
66. Morii K, Tanaka R, Takahashi Y, Minoshima S, Fukuyama R, Shimizu N, Kuwano R (1991) Structure and chromosome assignement of human S100α and β subunit genes. Biochem Biophys Res Commun 175:185-191
67. Nagamatsu M, Mokuno K, Sugimura K, Kiyosawa K, Aoki S, Takahashi A, Kato K (1995) Cerebrospinal fluid levels of S-100b protein and neuron-specific enolase in chronic inflammatory demyelinating polyneurolpathy. Acta Neurol Scand 91:483-487
68. Persson L, Hardemark HG, Gustafsson J, Rundström G, Mendel-Hartvig I, Esscher T, Pahlman S (1987) S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system. Stroke 18:911-918
69. Reeves RH, Yao J, Crowley MR, Buck S, Zhang X, Yarowsky P, Gearhart JD, Hilt DC (1994) Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice. Proc Natl Acad Sci 91:5359-5363
70. Rickmann M, Wolff JR (1995) S100 immunoreactivity in a subpopulation of oligodendrocytes and Ranvierís nodes of adult rat brain. Neurosci Lett 186:13-16
71. Schafer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (1995) Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Genomics 25:638-643
72. Schmidt S, Linington C, Zipp F, Sotgiu S, de Waal Malefyt R, Wekerle H, Hohlfeld R (1997) Multiple Sclerosis: Comparison of the human T cell response to S100b and MBP reveals parallels to rat experimental autoimmune panencephalitis (EAP). Brain 120:1437-1445
73. Schmidt S, Mundegar RR, Broich P, Haug K, Pels H, Ries F, Klingmüller D (1997) Serum and cerebospinal fluid concentrations of S100β and neuron-specific enolase in acute relapsing multiple sclerosis and other neurological diseases. Akt Neurol 24 [Suppl 1]:S50
74. Selinfreund RH, Barger SW, Pledger WJ, Van Eldik U (1991) Neurotrophic protein S-100β stimulates glial cell proliferation. Proc Natl Acad Sci 88:3554-3558
75. Selinfreund RH, Barger SW, Welch MJ, Van Eldik U (1990) Antisense inhibition of glial S100β production results in alterations in cell morphology, cytoskeletal organization, and cell proliferation. J Cell Biol 111:2021-2028
76. Sellman M, Ivert T, Ronquist G, Caesarini K, Persson L, Semb BKH (1991) Central nervous system damage during cardiac surgery assessed by 3 different biochemical markers in cerebrospinal fluid. Scand J Thoracic 26:39-45
77. Shashoua VE, Hesse GW, Moore BW (1984) Proteins of the brain extracellular fluid: evidence for release of S-100 protein. J Neuochem 42:1536-1541
78. Shaw PJ, Smith NM, Inca PG, Bates D (1987) Chonic periphlebitis retinae in multiple sclerosis. A histological study. J Neurol Sci 77:147-152
79. Sheng JG, Mrak RE, Griffin WST (1994) S100 beta protein expression in Alzheimer disease: potential role in the pathogenesis of neuritic plaques. J Neurosci Res 39:398-403
80. Sheng JG, Ito K, Skinner RD, Mrak RE, Rovnaghi CR, Van Eldik LJ, Griffin WS (1996) In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol Aging 17:761-766
81. Sheng JG, Mrak RE, Rovnaghi CR, Kozlowska E, Van Eldik LJ, Griffin WS (1996) Human brain S100 beta and S100 beta mRNA expression increases with age: pathogenic implications for Alzheimeris disease. Neurobiol Aging 17:359-363
82. Takahashi K, Isobe T, Ohtsuki Y, Akagi T, Sonobe H, Okuyama T (1984) Immunohistochemical study on the distribution of a and b subunits of S-100 protein in human neoplasm and normal tissues. Virchows Arch [B] 45:385-396
83. 0α, 28-kDa calbindin-D, S100b and CK-BB) in serum and cerebrospinal fluid after cardial arrest J Neurol Sci 123:134-139
84. Van Eldik LJ, Christie-Pope B, Bolin LM, Shooter EM, Whetsall WO (1991) Neurotrophic activity of S-100b in cultures of dorsal root ganglia from embryonic chick and fetal rat. Brain Res 542:280-285
85. Van Eldik LJ, Griffin WST (1994) S100β expression in Alzheimeris disease: relation to neuropathology in brain regions. Biochim Biophys Acta 1223:398-403
86. Van Eldik LJ, Hertzberg EL, Berdan RC, Gilula NB (1985) Interaction of calmodulin and other calcium-modulated proteins with mammalian and arthropod junctional membrane proteins. Biochem Biophys Res Commun 126:825-832
87. Van Eldik LJ, Staecker JL, Winnigham-Major F (1988) Synthesis and expression of a gene coding for the calcium-modulated protein S-100β and designed for cassette-based, site-directed mutagenesis. J Biol Chem 263:7830-7837
88. Van Eldik LJ, Zimmer DB (1987) Secretion of S-100 from rat C6 glioma cells. Brain Res 436: 367-370
89. Van Engelen BGM, Lamers KJB, Gabreels FJM, Wevers RA, van Geel WJA, Borm GF (1992) Age-related changes of neuron-specific enolase, S-100 protein, and myelin basic protein concentrations in cerebrospinal fluid. Clin Chem 38:813-816
90. Von Schoultz E, Hanssonl LO, Djureen E, Hansson J, Kärnell R, Nilsson B, Stigbrand T, Ringborg U (1996) Prognostic value of serum analyses of S-100b protein in malignant melanoma. Melanoma Res 6:133-137
91. Wekerle H, Kojima K, Lannes-Vieira J, Lassmann H, Linington C (1994) Animal models. Ann Neurol 36:S47-S53
92. Wekerle H, Linington C, Lassmann H, Meyermann R (1986) Cellular immune reactivity within the CNS. Trends Neurosci 9:271-277
93. Winnigham-Major F, Staecker JL, Barger S, Coats S, Van Eldik LJ (1989) Neurite extension and neuronal survival activities of recombinant S-100β proteins that differ in the content and position of cysteine residues. J Cell Biol 109:3063-3071
94. Zimmer DB, Cornwall EH, Landar A, Song W (1995) The S100 protein family: history, function, and expression. Brain Res Bull 37:417-429