Synergism between low-dose nicorandil and neuropeptides on adenosine-induced vasodepression in rats

European Journal of Pharmacology

Volumn 352, Issue 2-3, 1998, Pages 229-236

  Sakai, Kazushige ^a   Saito, Keiji ^a  

^a Central Research Laboratories   (Japan)

Author keywords

Adenosine induced vasodepression; CGRP (calcitonin gene related peptide); K(ATP) channel; Nicorandil; VIP (vasoactive intestinal polypeptide)

Indexed keywords

3,7 DIMETHYL 1 PROPARGYLXANTHINE; ACETYLCHOLINE; ADENOSINE; CALCITONIN GENE RELATED PEPTIDE; GLIBENCLAMIDE; NICORANDIL; POTASSIUM CHANNEL; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

EID: 0031903814     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00357-4     Document Type: Article

References (32)

1. Belloni, F.L., Hintze, T.H., 1991. Glibenclamide attenuates adenosine-induced bradycardia and coronary vasodilatation. Am. J. Physiol. 261, H720-H727.
2. 3H]NECA in rat strial membranes. Mol. Pharmacol. 29, 331-346.
3. Daut, J., Maier-Rudolph, W., von Beckerath, N., Mehrke, G., Gunter, K., Goedel-Meinen, L., 1990. Hypoxic dilation of coronary arteries is mediated by ATP-sensitive potassium channels. Science 247, 1341-1344.
4. Elhawary, A.M., Poon, J., Pang, C.C.Y., 1995. Effects of calcitonin gene-related peptide receptor antagonists on renal actions of adrenomedullin. Br. J. Pharmacol. 115, 1133-1140.
5. Franco-Cereceda, A., Saria, A., Lundberg, J.M., 1989. Differential release of calcitonin gene-related peptide and neuropeptide Y from the isolated heart by capsaicin, ischaemia, nicotine, bradykinin and ouabain. Acta. Physiol. Scand. 135, 173-187.
6. 2 receptor-mediated vasodepres- sion does not involve a pertussis toxin-sensitive G protein. Eur. J. Pharmacol. 236, 255-262.
7. Hamilton, T.C., Weston, A.H., 1989. Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle. Gen. Pharmacol. 20, 1-9.
8. Hori, M., Kitakaze, M., 1991. Adenosine, the heart, and coronary circulation. Hypertension 18, 565-574.
9. Ignarro, L.J., Byrns, R.E., Buga, G.M., Wood, K.S., 1987. Mechanisms of endothelium-dependent vascular smooth muscle relaxation elicited by bradykinin and VIP. Am. J. Physiol. 253, H1074-H1082.
10. Kinoshita, M., Sakai, K., 1990. Pharmacology and therapeutic effects of nicorandil. Cardiovasc. Drugs Ther. 4, 1075-1088.
11. 2 receptors and cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 92, 12441-12445.
12. + channels enhances both adenosine-induced coronary vasodilation and adenosine release in dogs. Circulation 92 (Suppl. I), I-637.
13. Krumenacker, M., Roland, E., 1992. Clinical profile of nicorandil: an overview of its haemodynamic properties and therapeutic efficacy. J. Cardiovasc. Pharmacol. 20, S93-S102.
14. Lefkowitz, R.J., Hoffman, B.B., Taylor, P., 1995. The autonomie and somatic motor nervous systems. In: Hardman, J.G., Limbird, L.E., Molinoff, P.B., Ruddon, P.W., Gilman, A.G. (Eds.), The Pharmacological Basis of Therapeutics. McGraw-Hill, New York, pp. 127-128.
15. Linden, J., Tucker, A.L., Robeva, A.S., Graber, S.G., Munshi, R., 1993. Properties of recombinant adenosine receptors. Drug Dev. Res. 28, 232-236.
16. Mair, J., Lechleiner, P., Langel, T., Wiedermann, C., Dienstl, F., Saria, A., 1990. Plasma CGRP in acute myocardial infarction. Lancet 335, 168-170.
17. Mubagwa, K., Mullane, K., Flaming, W., 1996. Role of adenosine in the heart and circulation. Cardiovasc. Res. 32, 797-813.
18. + Channels in Cardiovascular Medicine. Springer Verlag, France, pp. 95-106.
19. + channels. Nature 344, 770-773.
20. Rubino, A., Burnstock, G., 1996. Capsaicin-sensitive sensory-motor neurotransmission in the peripheral control of cardiovascular function. Cardiovasc. Res. 31, 469-479.
21. Saito, K., Sakai, K., 1998a. Enhancement of the vasodepressor response to adenosine by nicorandil in rats: comparison with cromakalim. Fundam. Clin. Pharmacol. 12, 37-43.
22. ATP channel activation in depressor responses to vasoactive neuropeptides in rats. Jpn. J. Pharmacol. 76, 227-231.
23. ATP channels. Fundam. Clin. Pharmacol. 12, 143-151.
24. Sakai, K., 1989. Nicorandil: animal pharmacology. Am. J. Cardiol. 63, 2J-10J.
25. ATP channels. Eur. J. Pharmacol. 345, 279-284.
26. Sakai, K., Akima, M., Saito, K., 1998a. Differential effects of nicorandil on the vasodepressor responses to vasoactive polypeptides administered intravenously to rats. J. Pharm. Pharmacol. 50, 211-214.
27. Sakai, K., Saito, K., Akima, M., 1998b. Synergistic effect of calcitonin gene-related peptide on adenosine-induced vasodepression in rats. Eur. J. Pharmacol. 344, 153-159.
28. Seale, T.W., Abla, K.A., Shamim, M.T., Carney, J.M., Daly, J.W., 1988. 3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs. Life Sci. 43, 1671-1684.
29. Sebastiao, A.M., Ribeiro, J.A., 1989. 1,3,8- and 1,3,7-substituted xanthines: relative potency as adenosine receptor antagonists at the frog neuromuscular junction. Br. J. Pharmacol. 96, 211-219.
30. Silver, P.J., Walus, K., DiSalvo, J., 1984. Adenosine-mediated relaxation and activation of cyclic AMP-dependent protein kinase in coronary arterial smooth muscle. J. Pharmacol. Exp. Ther. 228, 342-348.
31. + channels in arterial smooth muscle. Science 245, 177-180.
32. Taira, N., 1989. Nicorandil as a hybrid between nitrates and potassium channel activators. Am. J. Cardiol. 63, 18J-24J.