Structural and dynamic effects of point mutations in the recognition helix of the glucocorticoid receptor DNA-binding domain

Protein Engineering

Volumn 11, Issue 7, 1998, Pages 589-600

  Eriksson, Mats A L ^a,b   Nilsson, Lennart ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DNA binding domain; Estrogen receptor; Glucocorticoid receptor; Molecular dynamics; Protein DNA complex

Indexed keywords

DNA BINDING PROTEIN; ESTROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR;

ARTICLE; COMPUTER SIMULATION; CONFORMATIONAL TRANSITION; HYDROGEN BOND; MOLECULAR DYNAMICS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN DOMAIN;

EGA;

EID: 0031903790     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/11.7.589     Document Type: Article

References (36)

1. Baumann, H., Paulsen, K., Kovács, H., Berglund, H., Wright, A.P.H., Gustafsson, J.-Å. and Härd, T. (1993) Biochemistry, 32, 13463-13471.
2. Beato, M. (1989) Cell, 56, 335-344.
3. Berglund, H., Kovács, K., Dahlman-Wright, K., Gustafsson, J.-Å. and Härd, T. (1992) Biochemistry, 31, 12001-12011.
4. Berglund, H., Wolf-Watz, M., Lundbäck, T., van den Berg, S. and Härd, T. (1997). Biochemistry, 36, 11188-11197.
5. Besler, B.H., Merz, J.K.M. and Kollman, P.A. (1990) J. Comp. Chem., 11, 431-439.
6. Brooks, B.R., Bruccoleri, R.E., Olafsson, B.D., States, D. J., Swaminathan, S. and Karplus, M. (1983) J. Comp. Chem., 4, 187-217.
7. Brooks, C.L., III. and Karplus, M. (1983) J. Chem. Phys., 79, 6312-6325.
8. Danielsen, M., Hinck, M.L. and Ringold, G.M. (1989) Cell, 57, 1131-1138.
9. Dewar, M.J.S. and Merz, J.K.M. (1986) Organometallics, 5, 1494-1496.
10. Dewar, M.J.S. and Thiel, W.J. (1977) J. Am. Chem. Soc., 99, 4899-4906.
11. Eriksson, M.A.L. and Nilsson, L. (1995) J. Mol. Biol. 253, 453-472.
12. Eriksson, M.A.L., Berglund, H., Härd, T. and Nilsson, L. (1993) Proteins Struct. Fund. Genet., 17, 375-390.
13. Eriksson, M.A.L., Härd, T. and Nilsson, L. (1995) Biophys. J., 68, 1-25.
14. Gewirth, D.T. and Sigler, P. (1995) Nature Struct. Biol., 2, 386-394.
15. Jorgensen, W.L., Chandraseklar, J., Madura, J.D., Impey, R.W. and Klein, M.L. (1983) J. Chem. Phys., 79, 926-935.
16. Kraulis, P.J. (1991) J. Appl. Chrystallogr., 24, 946-950.
17. Laudet, V., Hänni, C., Coll, J., Catzeflis, F. and Stehelin, D. (1992) EMBO J., 11, 1003-1013.
18. Luisi, B.F., Xu, W.X., Otwinowski, Z., Freedman, L.R. Yamamoto, K.R. and Sigler, P.B. (1991) Nature, 352, 497-505.
19. Lundbäck, T., Zilliacus, J., Gustafsson, J.-Å., Carlstedt-Duke, J. and Härd, T. (1994) Biochemistry, 33, 5955-5965.
20. MacKerell, A.D., Wiorkeiewicz, J.K. and Karplus, M. (1995) J. Am. Chem. Soc., 117, 11946-11975.
21. Mader, S., Kumar, V., de Verneuil, H. and Chambon, P. (1989) Nature, 338, 271-274.
22. Ravishanker, G., Swaminathan, S., Beveridge, D.L., Lavery, R. and Sklenar, H. (1989) J. Biomol. Struct. Dyn., 6, 669-699.
23. Record, M.T., Jr., Ha, J.-H. and Fisher, M.A. (1991) Methods Enzymol., 208, 291-343.
24. Ryckaert, J.P., Ciccotti, G. and Berendsen, H. J.C. (1977) J. Comp. Phys., 23, 327-341.
25. Schwabe, J.W.R., Chapman, L., Finch, J.T. and Rhodes, D. (1993) Cell, 75, 567-578.
26. Schwabe, J.W.R., Neuhaus, D. and Rhodes, D. (1990) Nature, 348, 458-461.
27. Steward, J.J.P. (1990) J. Comput. Aided Mol. Des., 4, 1-45.
28. Truss, M. and Beato, M. (1993) Endocr. Rev., 14, 459-479.
29. Tsai, M.-J. and O'Malley, B.W. (1994) Annu. Rev. Biochem., 63, 451-486.
30. Umesono, K. and Evans, R.M. (1989) Cell, 57, 1139-1146.
31. Xu, W., Alroy, I., Freedman, L.F. and Sigler, P.B. (1993) Cold Spring Harbor Symp. Quant. Biol., 58, 133-139.
32. Zilliacus, J., Dahlman-Wright, K., Wright, A., Gustafsson, J.-Å. and Carlstedt-Duke, J. (1991) J. Biol. Chem., 266, 3101-3106.
33. Zilliacus, J., Wright, A.P.H., Norinder, U., Gustafsson, J.-Å. and Carlstedt-Duke, J. (1992) J. Biol. Chem., 267, 24941-24947.
34. Zilliacus, J., Carlstedt-Duke, J., Gustafsson, J.-Å. and Wright, A.P.H. (1994) Proc. Natl Acad. Sci. USA, 91, 4175-4179.
35. Zilliacus, J., Wright, A.P.H., Carlstedt-Duke, J. and Gustafsson, J.-Å. (1995a) Mol. Endocrinol., 9, 389-400.
36. Zilliacus, J., Wright, A.P.H., Carlstedt-Duke, J., Nilsson, L. and Gustafsson, J.-Å. (1995b) Proteins Struct. Funct. Genet., 21, 57-67.