Relation between gestational thrombocytopenia and the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome)

Gynecologic and Obstetric Investigation

Volumn 46, Issue 1, 1998, Pages 41-45

  Minakami, Hisanori ^a   Kohmura, Yasuhiro ^a   Izumi, Akio ^a   Watanabe, Takashi ^a   Matsubara, Shigeki ^a   Sato, Jkuo ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Hemolysis; Liver dysfunction; Preeclampsia; Thrombocytopenia

Indexed keywords

ANTITHROMBIN III; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASE;

ADULT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIRTH WEIGHT; CLINICAL ARTICLE; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; HELLP SYNDROME; HUMAN; LACTATE DEHYDROGENASE BLOOD LEVEL; NORMAL HUMAN; PREECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATION; PRIORITY JOURNAL; RECURRENT DISEASE; RETROSPECTIVE STUDY; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ASPARTATE AMINOTRANSFERASES; COHORT STUDIES; FEMALE; HELLP SYNDROME; HUMANS; PLATELET COUNT; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; RISK FACTORS; THROMBOCYTOPENIA;

EID: 0031903539     PISSN: 03787346     EISSN: None     Source Type: Journal    
DOI: 10.1159/000009995     Document Type: Article

References (24)

1. Redman CWG, Bonnar J, Beilin L: Early platelet consumption in pre-eclampsia. BMJ 1978;i:467-469.
2. Ahmed Y, van Iddekinge B, Paul C, Sullivan MHF, Eider MG: Retrospective analysis of platelet numbers and volumes in normal pregnancy and in pre-eclampsia, Br J Obstet Gynaecol 1993;100:216-220.
3. Tygart SG, McRoyan DK, Spinnato JA, McRoyan CJ, Kitay DZ: Longitudinal study of platelet indices during normal pregnancy. Am J Obstet Gynecol 1986;154:883-887.
4. Burrows RF, Kelton JG: Fetal thrombocytopenia and its relation to maternal thrombocytopenia. N Engl J Med 1993;329:1463-1466.
5. Freedman J, Musclow E, Garvey B, Abbott D: Unexplained periparturient thrombocytopenia. Am J Hematol 1986;21:397-407.
6. George JN, El-Harake MA, Raskob GE: Chronic idiopathic thrombocytopenic purpura. N Engl J Med 1994;331:1207-1211.
7. Minakami H, Kuwata T, Sato I: Gestational thrombocytopenia: Is it new? Am J Obstet Gynecol 1996;175:1676-1677.
8. Weinstein L: Syndrome of hemolysis, elevated liver enzymes, and low platelet count: A severe consequence of hypertension in pregnancy. Am J Obstet Gynecol 1982;142:159-167.
9. Goodlin RC, Holdt D: Impending gestosis. Obstet Gynecol 1981;58:743-745.
10. Schwartz ML, Brenner W: Toxemia in a patient with none of the standard signs and symptoms of preeclampsia. Obstet Gynecol 1985;66:19S-21S.
11. Aarnoudse G, Houthoff HJ, Weits J, Vellenga E, Huisjes HJ: A syndrome of liver damage and intravascular coagulation in the last trimester of normotensive pregnancy: A clinical and histopathological study. Br J Obstet Gynecol 1986;93:145-155.
12. Sibai BM: The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): Much ado about nothing? Am J Obstet Gynecol 1990;162:311-316.
13. Magann EF, Chauhan SP, Naef RW, Blake PG, Morrison JC, Martin JN: Standard parameters of preeclampsia: Can the clinician depend upon them to reliably identify the patient with the HELLP syndrome? Aust NZ J Obstet Gynecol 1993;33:122-126.
14. Miettinen OS: Estimability and estimation in case-referent studies. Am J Epidemiol 1976;103:226-235.
15. Paternoster DM, Stella A, Simioni P, Mussap M, Plebani M: Coagulation and plasma fibronectin parameters in HELLP syndrome. Int J Gynecol Obstet 1995;50:263-268.
16. Martin JN, Blake PG, Perry KG, McCaul JF, Hess LW, Martin RW: The natural history of HELLP syndrome: Patterns of disease progression and regression. Am J Obstet Gynecol 1991;164:1500-1513.
17. Schrocksnadel H, Sitte B, Steckel-Berger G, Dapunt O: Hemolysis in hypertensive disorders of pregnancy. Gynecol Obstet Invest 1992;34:211-216.
18. Minakami H, Oka N, Sato T, Tamada T, Yasuda Y, Hirota N: Preeclampsia: A micro vesicular fat disease of the liver? Am J Obstet Gynecol 1988;159:1043-1047.
19. Minakami H, Sato T, Takahashi T, Oka N, Tamada T: Clinical significance of serum GOT elevation and thrombocytopenia in preeclampsia patients. Nippon Sanka Fujinka Gakkai Zasshi, 1988;40:754-760.
20. Minakami H, Tamada T: Hepatic histopathologic characteristics in HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count). Am J Obstet Gynecol 1993;169:1357.
21. Minakami H, Sugimoto H, Manaka C, Takahashi T, Sato I, Tamada T: HELLP syndrome: CT evaluation. Gynecol Obstet Invest 1994;38: 28-30.
22. Sullivan CA, Magann EF, Perry KG Jr, Roberts WE, Blake PG, Martin JN Jr: The recurrence risk of the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP) in subsequent gestations. Am J Obstet Gynecol 1994;171:940-943.
23. Fay RA, Hughes AO, Farron NT: Platelets in pregnancy: Hyperdestruction in pregnancy. Obstet Gynecol 1983;61:238-240.
24. Jackson CW, Steward SA, Ashmun RA, McDonald TP: Megakaryocytopoiesis and platelet production are stimulated during late pregnancy and early postpartum in the rat. Blood 1992;79:1672-1678.