Treatment of recurrent genital herpes with interferon alpha-2α

Gynecologic and Obstetric Investigation

Volumn 46, Issue 1, 1998, Pages 54-57

  Cardamakis, E ^a,b,c   Relakis, K ^a,b   Kotoulas, I G ^a,b   Michopoulos, J ^a,b   Metallinos, K ^a,b   Mantouvalos, H ^a,b   Tzingounis, F ^a,b  

^a UNIVERSITY OF PATRAS   (Greece)

^b HELENA VENIZELOU HOSPITAL   (Greece)

^c Aheon 24 ^*  (Greece)

Author keywords

Genital herpes; Interferon alpha 2 ; Prophylaxis, genital herpes

Indexed keywords

ALPHA2 INTERFERON; RECOMBINANT ALPHA2A INTERFERON;

ADULT; ARTICLE; BURN; CHILL; CLINICAL TRIAL; DISEASE DURATION; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; FEVER; FLU LIKE SYNDROME; GENITAL HERPES; HEALING; HUMAN; MAJOR CLINICAL STUDY; MALAISE; MALE; PAIN; PRIORITY JOURNAL; PRURITUS; RECURRENT DISEASE; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; CHI-SQUARE DISTRIBUTION; DRUG ADMINISTRATION SCHEDULE; FEMALE; HERPES GENITALIS; HUMANS; INJECTIONS, SUBCUTANEOUS; INTERFERON ALFA-2A; MALE; RECURRENCE;

EID: 0031903478     PISSN: 03787346     EISSN: None     Source Type: Journal    
DOI: 10.1159/000009998     Document Type: Article

References (28)

1. Corey L, Adams HG, Brown ZA, Holmes KK: Genital herpes simplex virus infections: Clinical manifestations, course and complications. Ann Intern Med 1983;98:958-972.
2. Reichman RC, Badjer CJ, Mertz GJ, et al: Treatment of recurrent genital herpes simplex infections with oral acyclovir. JAMA 1984;251:2103-2107.
3. Douglas JM, Gritchlow C, Benedetti J, et al: A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. N Engl J Med 1984;310:1551-1556.
4. Straus SE, Takitt NE, Seidlin M, et al: Suppression of frequently recurring genital herpes: A placebo-controlled double-blind trial of oral acyclovir. N Engl J Med 1984;310:1545-1550.
5. Chatterjee S, Hunter E, Whitley R: Effect of cloned human interferons on protein synthesis and morphogenesis of herpes simplex virus. J Virol 1985;56:419-425.
6. Overall JC, Tre-Jou Y, Kern ER: Sensitivity of herpes simplex virus 1 and 2 to three preparations of human Interferon. J Infect Dis 1980;142:943.
7. Kuhls TL, Sacher J, Pineda E, et al: Suppression of recurrent genital HSV infection by recombinant alpha 2 interferon in patients with frequent recurrences. J Infect Dis 1986;154:437-442.
8. Lebwohl M, Gordon M, Conant M, Connor J, Eron L: Recombinant α-2 interferon in the treatment of recurrent herpes genitalis. J Invest Dermatol 1987;88:505.
9. De Koning EWJ, Van Bijsterveld OP, Cantell K: Combination therapy of dendritic keratitis with human leukocyte interferon and trifluorothymidine. Br J Ophthalmol 1983;66:509-512.
10. Eron LJ, Toy C, Santomauro D: Interferon therapy of recurrences of genital herpes; in Kono R, Nakajima A (eds): Herpesviruses and Virus Chemotherapy. Amsterdam, Elsevier, 1985, pp 277-278.
11. Fish EN, Banerjee K. Stebbing N: Efficacy of consensus interferon alpha against HSV-2 infections. Antiviral Res 1985;5(suppl 1):191-197.
12. Lazar R, Breiwing MK, Armstrong JA, Ho M: Response of cloned progeny of clinical isolates of herpes simplex virus to human leukocyte interferon. Infect Immun 1980;27:708-712.
13. Lerner AM, Bailey EJ: Differential sensitivity of herpes simplex virus types 1 and 2 to human interferon: Antiviral effects of interferon plus 9-β-Δ-arabinofuranosyladenine. J Infect Dis 1976;134:400-404.
14. Rapp F, Wrzos H: Synergistic effect of human leukocyte Interferon and nonoxynol 9 against herpes simplex virus type 2. Antimicrob Agents Chemother 1985;28:449-451.
15. Parin GJ, Armstrong JA, Lam MT, Tarr GC, Janetta PJ, Ho M: Prevention of reactivated herpes simplex infection by human leukocyte Interferon after operation on the trigeminal root. N Engl J Med 1979;301:225-230.
16. Olsen CA, Trofatter KF, Gall SA: Human lymphoblastoid alpha-interferon in the treatment of refractory condyloma acuminata. J Invest Dermatol 1985;84:359.
17. Pazin GJ, Haryer JH, Armstrong JA, et al: Leukocyte interferon for treating first episodes of genital herpes in women. J Infect Dis 1987;156:891-898.
18. Mendelson J, Cleener B, Eiley S: Effect of recombinant interferon-α2 on clinical course of first episode genital herpes infection and subsequent recurrences. Genitourin Med 1986;62:97-101.
19. Lassur A, Beryelin I, Palorista A, Rinne E, Eskelinen A, Saila K: Efficacy of Interferon and placebo in the treatment of recurrent genital herpes: A double-blind trial. Sex Transm Dis 1987;14:185-190.
20. Levin MJ, Judson FN, Eron L, et al: Comparison of intramuscular recombinant alpha Interferon (rIFN-2A) with topical acyclovir for the treatment of first-episode herpes genitalis and prevention of recurrences. Antimicrob Agents Chemother 1989;33:649-652.
21. Eron LJ, Toy C, Salsitz B, Scheer RR, Wood DL, Nadler PI: Therapy of genital herpes with topically applied interferon. Antimicrob Agents Chemother 1987;31:1137-1139.
22. Lotrova E, Savary CA, Gutterman JU, Hersch EM: Modulation of natural killer cell-mediated cytotoxicity by partially purified and cloned interferon-alpha. Cancer Res 1982;42:2480-2488.
23. Masucci MG, Szigeti R, Klein E, et al: Effect of interferon-alpha 1 from E. coli on some cell functions. Science 1980;209:1431-1435.
24. Platsoucas CD, Fernandes G, Gupta SL, et al: Defective spontaneous and antibody dependent cytotoxicity mediated by E-rosette-positive and E-rosette-negative cells in untreated patients with chronic lymphocytic leukemia: Augmentation by in vitro treatment with interferon. J Immunol 1980;125:1216-1223.
25. Silva A, Bonavida B, Taryan S: Mode of action of inteferon-mediated modulation of natural killer cytotoxic activity: Recruitment of pre-NK cells and enhanced kinetics of lysis. J Immunol 1980;125:479-484.
26. Taryan S, Stebbin N: In vitro interactions of purified cloned interferons on NK cells enhanced activation. J Immunol 1982;129:934-935.
27. Trinchieri G, Santoli D: Antiviral activity induced by culturing lymhocytes with tumor-derived virus-transformed cells. J Exp Med 1978;147:1314-1333.
28. Friedman-Kien AE, Klein RJ, Glasser ERD, Czelusniak SM: Treatment of recurrent genital herpes with topical alpha interferon gel combined with nonoxynol 9. J Am Acad Dermatol 1986;15:989-994.