Viral determinants of rotavirus pathogenicity in pigs: Evidence that the fourth gene of a porcine rotavirus confers diarrhea in the homologous host

Journal of Virology

Volumn 72, Issue 8, 1998, Pages 6929-6931

  Bridger, Janice C ^a   Tauscher, Gabriele I ^b   Desselberger, Ulrich ^b  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIARRHEA; ELECTROPHORETIC MOBILITY; GENETIC VARIABILITY; GNOTOBIOTICS; NONHUMAN; PRIORITY JOURNAL; ROTAVIRUS; SEQUENCE ANALYSIS; SWINE; VIRUS EXCRETION; VIRUS LOAD; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS TITRATION; VIRUS VIRULENCE;

EID: 0031903187     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.8.6929-6931.1998     Document Type: Article

References (23)

1. Ball, J. M., P. Tian, C. Q. Y. Zeng, A. P. Morris, and M. K. Estes. 1996. Age dependent diarrhea induced by a rotavirus nonstructural glycoprotein. Science 272:101-104.
2. Bridger, J. C. 1980. Rotaviruses: the present situation in farm animals. Vet. Annu. 20:172-179.
3. Bridger, J. C. 1994. A definition of bovine rotavirus virulence. J. Gen. Virol. 75:2807-2812.
4. Bridger, J. C., and J. F. Brown. 1984. Antigenic and pathogenic relationship of three bovine rotaviruses and a porcine rotavirus. J. Gen. Virol. 65:1151-1158.
5. 3a. Bridger, J. C., and D. H. Pocock. 1986. Variation in virulence of bovine rotaviruses. J. Hyg. 96:257-264.
6. Bridger, J. C., B. Burke, G. M. Beards, and U. Desselberger. 1992. The pathogenicity of two porcine rotaviruses differing in their in vitro growth characteristics and gene 4. J. Gen. Virol. 73:3011-3015.
7. Broome, R. L., P. T. Vo, R. L. Ward, H. F. Clark, and H. B. Greenberg. 1993. Murine rotavirus genes encoding outer capsid proteins VP4 and VP7 are not major determinants of host range restriction and virulence. J. Virol. 67:2448-2455.
8. Burke, B., and U. Desselberger. 1996. Rotavirus pathogenicity. Virology 218: 299-305.
9. Burke, B., M. A. McCrae, and U. Desselberger. 1994. Sequence analysis of two porcine rotaviruses differing in growth in vitro and in pathogenicity: distinct VP4 sequences and conservation of NS53, VP6 and VP7 genes. J. Gen. Virol. 75:2205-2212.
10. de Zoysa, I., and R. G. Feachem. 1985. Interventions for the control of diarrhoeal diseases among young children: rotavirus and cholera immunization. Bull. W. H. O. 63:569-583.
11. Estes, M. K. 1996. Rotaviruses and their replication, p. 1625-1655. In B. N. Fields, D. N. Knipe, P. M. Howley, R. M. Chanock, J. L. Melnick, T. P. Monath, B. Roizman, and S. E. Straus (ed.), Fields virology, 3rd ed. Lippincott-Raven, Philadelphia, Pa.
12. Gorziglia, M., K. Green, K. Nishikawa, K. Taniguchi, R. Jones, A. Z. Kapikian, and R. M. Chanock. 1988. Sequence of the fourth gene of human rotaviruses recovered from asymptomatic or symptomatic infections. J. Virol. 62:2978-2984.
13. Haddow, J., B. Clark, Y. M. Ni, and U. Desselberger. 1989. Biological function of the rotavirus protein VP4: observations on porcine rotaviruses from China. Med. Microbiol. Immunol. 178:163-176.
14. Hall, G. A., J. C. Bridger, K. R. Parsons, and R. Cook. 1993. Variation in rotavirus virulence: a comparison of pathogenesis in calves between two rotaviruses of different virulence. Vet. Pathol. 30:223-233.
15. Hoshino, Y., L. J. Saif, S. Y. Kang, M. M. Sereno, W. K. Chen, and A. Z. Kapikian. 1995. Identification of group A rotavirus genes associated with virulence of a porcine rotavirus and host range restriction of a human rotavirus in the gnotobiotic piglet model. Virology 209:274-280.
16. Kapikian, A. Z., and R. M. Chanock. 1996. Rotaviruses, p. 1657-1708. In B. N. Fields, D. N. Knipe, P. M. Howley, R. M. Chanock, J. L. Melnick, T. P. Monath, B. Roizman, and S. E. Straus (ed.), Fields virology, 3rd ed. Lippincott-Raven, Philadelphia, Pa.
17. Offit, P. A. 1994. Rotaviruses: immunological determinants of protection against infection and disease. Adv. Virus. Res. 44:161-202.
18. Offit, P. A., G. Blavat, H. B. Greenberg, and H. F. Clark. 1986. Molecular basis of rotavirus virulence: role of gene segment 4. J. Virol. 57:46-49.
19. Reynolds, D. J., J. H. Morgan, N. Chanter, P. W. Jones, J. C. Bridger, T. G. Debney, and K. J. Bunch. 1986. Microbiology of calf diarrhoea in Southern Britain. Vet. Rec. 119:34-39.
20. Snodgrass, D. R., H. R. Terzolo, D. Sherwood, I. Campbell, J. D. Menzies, and B. A. Synge. 1986. Aetiology of diarrhoea in young calves. Vet. Rec. 119:31-34.
21. Tauscher, G. I., and U. Desselberger. 1997. Viral determinants of rotavirus pathogenicity in pigs: production of reassortants by asynchronous coinfection. J. Virol. 71:853-857.
22. Torres-Medina, A., R. G. Wyatt, C. A. Mebus, N. R. Underdahl, and A. Z. Kapikian. 1976. Diarrhea caused in gnotobiotic piglets by the reovirus-like agent of human infantile gastroenteritis. J. Infect. Dis. 133:22-27.
23. Ward, L. A., B. I. Rosen, L. Yuan, and L. J. Saif. 1996. Pathogenesis of an attenuated and a virulent strain of a group A human rotavirus in neonatal gnotobiotic pigs. J. Gen. Virol. 77:1431-1441.