Clinical significance of intrahepatic hepatitis C virus levels in patients with chronic HCV infection

Gut

Volumn 42, Issue 4, 1998, Pages 570-575

  Haydon, G H ^a   Jarvis, L M ^a   Blair, C S ^a   Simmonds, P ^a   Harrison, D J ^a   Simpson, K J ^a   Hayes, P C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Chronic hepatitis C virus infection; Intrahepatic hepatitis C virus

Indexed keywords

ALPHA INTERFERON; VIRUS RNA;

ADULT; AGE; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; FEMALE; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HISTOLOGY; HUMAN; HUMAN TISSUE; LAPAROSCOPY; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0031902847     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.42.4.570     Document Type: Article

References (47)

1. Choo QL, Kuo G, Weiner AJ, et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis. Science 1989;244:359.
2. Kuo G, Choo Q-L, Alter HJ, et al. An assay for circulating antibodies to a major etiological virus of human non-A, non-B hepatitis. Science 1989;244:362.
3. Kato N, Hijikata M, Ootsuyama Y, et al. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc Natl Acad Sci 1990;87:9524-8.
4. Alter HJ, Purcell RH, Shih JW. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic liver disease. N Engl J Med 1989;2:1494 500.
5. Esteban JI, Esteban R, Viladomiu I, et al. Hepatitis C antibodies amongst risk groups in Spain. Lancet 1989,ii: 294 8.
6. Courouce AM, Bouchardeau F, Girault A. Significance of NS3 and Ns5 antigens in screening for HCV antibody. Lancet 1994;343:853 4.
7. Bousch MP, Tobler LH, Francis BS, Re-instatement of blood donors who test false-positive in second generation hepatitis C virus enzyme immunoassay should await availability of licensed third-generation tests. Transfusion 1994; 34:130 4.
8. Alberti A, Morsica G, Chemello L, et al. Hepatitis C viraemia and liver disease in symptom free individuals with antiHCV. Lancet 1992;340:697 8.
9. Booth JCL, Brown JL, Thomas HC. The management of chronic hepatitis C infection. Gut 1995;37:444 54.
10. Kato N, Yokosuka O, Hosoda K, et al. Quantification of hepatitis C virus by competitive reverse transcription polymerase chain reaction: increase of the virus in advanced liver disease. Hepatology 1993;18:16 20.
11. Yuki N, Hayashi N, Kamada T. HCV viraemia and liver injury in symptom tree blood donors [letter], Lancet 1993; 342:444.
12. Hu KQ, Yu CH, Vierling JM. Direct detection of circulating hepatitis C virus RNA using probes from the 5′ untranslated region. J Clin Invest 1992;89:2040 5.
13. Lau JY, Davis GL, Kniffen J, et al. Significance of serum hepatitis C virus RNA levels in chronic hepatitis C. Lancet 1993;341:1501 4.
14. Gunji T, Kato N, Mori S, et al. Correlation between the serum level of hepatitis C. virus RNA and disease activities in acute and chronic hepatitis C. Int J Cancer 1992;52:726 30.
15. Kaneko S, Murakami S, Unoura M, et al. Quantification of hepatitis C virus RNA by competitive polymerase chain reaction. J Med Virol 1992;37:278 82.
16. Kobayashi Y, Watanabe S, Konishi M, et al. Quantification and typing of serum hepatitis C virus RNA in patients with chronic hepatitis C treated with interferon-beta. Hepatology 1993;18:1319 25.
17. Chayama K, Tsubota A, Arase Y, et al. Quantitative analysis of hepatitis C virus RNA by competitive nested polymerase chian reaction. J Gastroenterol Hepatol 1993;8:S40-4.
18. Jeffers L, Dailey P, Coelholittle E, et al. Correlation of HCV RNA quantitation in sera and liver tissue of patients with chronic C hepatitis [abstract] Gastroenterology 1993;104: A923.
19. Sakamoto N, Enomoto N, Kurosaki M, et al. Dectection and quantification of hepatitis C virus RNA replication in the liver. J Hepatol 1994;20:593 7.
20. Nakagawa H, Shimomura H, Hasui T, et al. Quantitative detection of hepatitis C, virus genome in liver tissue and circulation by competitive reverse transcription polymerase chain reaction. Dig Dis Sci 1994;39:225-33.
21. Fong TL, Shindo M, Feinstone SM, et al. Dectection of replicative intermediates of hepatitis C viral RNA in liver and serum of patients with chronic hepatitis C. J Clin Invest 1991;88:1058-60.
22. Lau G, Fang J, Davis G, Gish R, et al. Detection of hepatitis C (HCV) genome in liver by in-situ reverse transcription (IS-RT-PCR) (abstract). Gastroenterology 1994;106:A295.
23. Noun-Aria KT, Sallie R, Sanger D, et al. Detection of genomic and intermediate replicative strands of hepatitis C virus in liver by in-situ hybridization. J Clin Invest 1993;91: 2226-34.
24. Haruna Y, Hayashi N, Hiramatsu N, et al. Detection of hepatitis C virus RNA in liver tissues by an in-situ hybridization technique. J Hepatol 1993;18:96-100.
25. Marrone A, Kleiner D, Mahaney K, et al. The significance of hepatic HCV RNA: analysis by semi-quantitative in-situ hybridisation. Hepatology 1994;20:236A.
26. Di-Bisceglie AM, Hoofnagle JH, Krawczynski K. Changes in hepatitis C virus antigen in liver with antiviral therapy. Gastroenterology 1993;105:858-62.
27. Hiramatsu N, Hayashi N, Haruna Y, et al. Immunohistochemical detection of hepatitis C virus-infected hepatocytes in chronic liver disease with monoclonal antibodies to core, envelope and NS3 regions of the hepatitis C virus genome. Hepatology 1992;16:306-11.
28. Blight K, Rowland R, Hall PD, et al. Immunohistochemical detection of the NS4 antigen of hepatitis C virus and its relationship to histopathology. Am J Pathol 1993;143:1568-73.
29. McGuiness PH, Bishop GA, Painter DM, et al. Intrahepatic hepatitis C RNA levels do not correlate with degree of liver injury in patients with chronic hepatitis C. Hepatology 1996;23:676-87.
30. Lau JY, Mizokami M, Kolberg KA, et al. Application of six hepatitis C genotyping systems to sera from chronic hepatitis C patients in the United States. J Infect Dis 1995;171: 281-9.
31. Vamada M, Kakumu S, Yohioka K, et al. Hepatitis C virus genotypes are not responsible for development of serious liver disease. Dig Dis Sci 1994;39:234-9.
32. Hayashi J, Kihihara Y, Yoshimura E, et al. Relationship of genotype to level of hepatitis C viraemia determined by competitive polymerase chain reaction. J Infect 1995;30: 235-9.
33. Jarvis LM, Watson HG, McOmish F, et al. Frequent reinfection and reactivation of hepatitis C virus genotypes in multitransfused haemophiliacs. J Infect Dis 1994;170:1018.
34. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
35. Chan SW, McOmish F, Holmes EC, et al. Analysis of a new hepatitis C virus type and its phylogenetic relationship to existing variants. J Gen Virol 1992;73:1131.
36. Nakao T, Enomoto N, Takada N, et al. Typinf of hepatitis C virus (HCV) genomes by restriction fragment polymorphisms. J Gen Virol 1991;72:2105-12.
37. McOmish F, Chan S-W, Dow BC, et al. Detection of three types of hepatitis C virus in blood donors: investigation of type-specific differences in serological reactivity and rate of alanine aminotransferase abnormalities. Transfusion 1993; 33:7-13.
38. McOmish F, Yap PL, Dow BC, et al. Geographical distribution of hepatitis C virus genotypes in blood donors - an international collaborative survey. J Clin Microbiol 1994;31: 884-92.
39. Simmonds P, Smith DB, McOmish F, et al. Identification of genotypes of hepatitis C virus by sequence analysis comparisons in the core, E1 and NS-5 regions. J Gen Virol 1994;75:1053-61.
40. Simmonds P, Balfe P, Peutherer JF, et al. Human immnuo-deficiency virus-infected individuals contain provirus in small numbers of peripheral mononuclear cells and at low copy numbers. J Virol 1990;64:864-72.
41. Simmonds P, Zhang LQ, Watson HG, et al. Hepatitis C quantification and sequencing in blood products, haemophiliacs, and drug users. Lancet 1990;336:1469-72.
42. Hawkins A, Davidson F, Simmonds P. Comparison of plasma virus loads among individuals infected with hepatitis C virus (HCV) genotypes 1,2 and 3 by quantiplax HCV RNA assay versions 1 and 2, Roche Monitor assay, and an in-house dilution method. J Clin Microbiol 1997;35:187 92.
43. Knodell RG, Ishak KG, Black WC, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981;1:431-5.
44. Irving WL, Neal KR, Underwood JCE, et al. Chronic hepatitis in United Kingdom blood donors infected with hepatitis C virus. Lancet 1994;308:695-6.
45. Alberti A, Morsica G, Chemello L, et al. Hepatitis C viraemia and liver disease in symptom free individuals with anti-HCV. Lancet 1992;340:697-8.
46. Gunji T, Kato N, Hijikata M, et al. Specitic detection of positive and negative stranded hepatitis C viral RNA using chemical RNA modification. Arch Virol 1994;134:293 302.
47. Lanford RE, Sureau C, Jacob JR, et al. Demonstration of in vitro infection of chimpanzee hepatocytes with hepatitis C virus using strand specific RT/PCR. Virology 1994;202: 606-14.