Fibroblasts from post-burn hypertrophic scar tissue synthesize less decorin than normal dermal fibroblasts

Clinical Science

Volumn 94, Issue 5, 1998, Pages 541-547

  Scott, P G ^a   Dodd, C M ^a   Ghahary, A ^a   Shen, Y J ^a   Tredget, E E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Decorin; Hypertrophic scar; Proteoglycans

Indexed keywords

BIGLYCAN; DECORIN; DERMATAN SULFATE; GLYCOSAMINOGLYCAN; MESSENGER RNA; PROTEOGLYCAN; TRANSFORMING GROWTH FACTOR BETA1; VERSICAN;

ADOLESCENT; ADULT; ARTICLE; BURN; CELL STRAIN; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; FEMALE; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; HYPERTROPHIC SCAR; IMMUNOBLOTTING; MALE; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; SKIN BIOPSY; SKIN FIBROBLAST;

EID: 0031902585     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0940541     Document Type: Article

References (46)

1. Linares HA, Kischer CW, Dobrkovsky K, Larson DL. (1972) The histiotypic organization of the hypertrophic scar in humans. J Invest Dermatol 59: 323-31.
2. Bailey AJ, Bazin S, Sims TJ, LeLous M, Nicoletis C, DeLaunay A. (1975) Characterization of the collagen of human hypertrophic and normal scars. Biochim Biophys Acta 405: 412-21.
3. Shetlar MR, Dobrkovsky M, Linares HA, Villarante R, Shetlar CL, Larson DL. (1971). The hypertrophic scar. Glycoprotein and collagen components of burn scars. Proc Soc Exp Biol Med 138: 298-300.
4. Kischer CW, Hendrix MJC. (1983) Fibronectin (FN) in hypertrophic scars and keloids. Cell Tissue Res 231: 29-37.
5. Shetlar MR, Shetlar CL, Linares HA. (1977) The hypertrophic scar: location of glycosaminoglycans within scars. Burns 4: 14-19.
6. Alexander SA, Donoff RB. (1980) The histochemistry of glycosaminoglycans within hypertrophic scars. J Surg Res 28: 171-81.
7. Heinegard D, Sommarin Y. (1987) Proteoglycans: an overview. Methods Enzymol 144: 305-19.
8. Choi HU, Johnson TL, Pal S, Tang L-H, Rosenberg L, Neame PJ. (1989) Characterization of the dermatan sulphate proteoglycans, DS-PGI and DS-PGII, from bovine articular cartilage and skin isolated by octyl-Sepharose chromatography. J Biol Chem 264: 2876-84.
9. Vogel KG, Ordog A, Pogany G, Olah J. (1993) Proteoglycans in the compressed region of human tibialis posterior tendon and in ligaments. J Orthop Res 11: 68-77.
10. Roughley PJ, White RJ. (1992) The dermatan sulfate proteoglycans of the adult human meniscus. J Orthop Res 10: 631-7.
11. Scott PG, Nakano T, Dodd CM. (1995) Small proteoglycans from different regions of the fibrocartilaginous temporomandibular joint disc. Biochim Biophys Acta 1244: 121-8.
12. Zimmerman DR, Dours-Zimmerman MT, Schubert M, Bruckner-Tuderman L. (1994) Versican is expressed in the proliferating zone in the epidermis and in association with the elastic network of dermis. J Cell Biol 124: 817-25.
13. Scott PG, Dodd CM, Tredget EE, Ghahary A, Rahemtulla F. (1995) Immunohistochemical localization of the proteoglycans decorin, biglycan and versican and transforming growth factor-β in human post-burn hypertrophic and mature scars. Histopathology 26: 423-31.
14. Scott PG, Dodd CM, Tredget EE, Ghahary A, Rahemtulla F. (1996) Chemical characterization and quantification of proteoglycans in human post-burn hypertrophic and mature scars. Clin Sci 90: 417-25.
15. Scott PG, Ghahary A, Chambers MM, Tredget EE. (1994) Biological basis of hypertrophic scarring. In: Malhotra SK, ed. Advances in structural biology, vol. 3. Greenwich, Connecticut: JAI Press Inc, pp. 157-201.
16. Nakano T, Scott PG. (1986) Purification and characterization of a gelatinase produced by fibroblasts from human gingiva. Biochem Cell Biol 64: 387-93.
17. Mechanic G. (1979) Collagen biochemistry. In: Simmons DJ, Kumin AS, eds. Skeletal research: an experimental approach. New York: Academic Press, pp. 227-41.
18. Pearson CH, Winterbottom N, Fackre DS, Scott PG, Carpenter MR. (1983) The amino-terminal sequence of bovine skin proteodermatan sulphate. J Biol Chem 258: 15101-4.
19. Pringle GA, Dodd CM, Osborn JW, Pearson CH, Mossman TR. (1985) Production and characterization of monoclonal antibodies to bovine skin proteodermatan sulfate. Collagen Rel Res 5: 23-39.
20. Scott PG, Dodd CM, Pringle GA. (1993) Mapping the locations of the epitopes of five monoclonal antibodies to the core protein of dermatan sulfate proteoglycan II (decorin). J Biol Chem 268: 11558-64.
21. Krusius T, Ruoslahti E. (1986) Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA. Proc Natl Acad Sci USA 83: 7683-7.
22. Krusius T, Gehlsen KR, Ruoslahti E. (1987) A fibroblast chondroitin sulphate proteoglycan core protein contains lectin-like and growth factor-like sequences. J Biol Chem 262: 13120-5.
23. Fisher LW, Termine JD, Young MF. (1989) Deduced protein sequence of a bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. J Biol Chem 264: 4571-6.
24. Chirgwin JM, Pryzbala AE, MacDonald RJ, Rutter WJ. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonucleases. Biochemistry 18: 5294-9.
25. Ghahary A, Shen YJ, Scott PG, Gong Y, Tredget EE. (1993) Enhanced expression of mRNA for transforming growth factor β1, type I and type III procollagen in post-burn hypertrophic scar tissues. J Clin Lab Med 122: 465-73.
26. Tan EML, Hoffren J, Rouda S, et al. (1993) Decorin, versican and biglycan gene expression by keloid and normal dermal fibroblasts: differential regulation by basic fibroblast growth factor. Exp Cell Res 209: 200-7.
27. Ghahary A, Scott PG, Malhotra S, et al. (1992) Differential expression of type I and type III procollagen mRNA in human hypertrophic burn fibroblasts. Biomed Lett 47: 169-84.
28. Swann DA, Garg HG, Hendry CJ, et al. (1988) Isolation and partial characterization of dermatan sulfate proteoglycans from human post-burn scar tissues. Collagen Rel Res 8: 295-313.
29. Wang R, Ghahary A, Shen YJ, Scott PG, Tredget EE. (1997) Nitric oxide synthase expression and nitric oxide production are reduced in hypertrophic scar tissue and fibroblasts. J Invest Dermatol 106: 438-44.
30. Ghahary A, Shen YJ, Nedelec B, Wang R, Scott PG, Tredget EE. (1996) Collagenase production is lower in post-burn hypertrophic scar fibroblasts than in normal fibroblasts and is reduced by insulin-like growth factor-1. J Invest Dermatol 106: 476-81.
31. Kischer CW, Wagner HN, Pindur J, et al. (1989) Increased fibronectin production by cell lines from hypertrophic scar and keloid. Connect Tissue Res 23: 279-88.
32. Schonherr E, Beavan LA, Hausser H, Kresse H, Culp LA. (1993) Differences in decorin expression by papillary and reticular fibroblasts in vivo and in vitro. Biochem J 290, 893-9.
33. Ignotz RA, Massague J. (1986) Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 261: 4337-45.
34. Kahari V-M, Larjava H, Uitto J. (1991) Differential regulation of extracellular matrix proteoglycan (PG) gene expression. J Biol Chem 266: 10608-15.
35. Edwards DR, Murphy G, Reynolds JJ, et al. (1987) Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 6: 1899-904.
36. Ghahary A, Shen YJ, Scott PG, Tredget EE. (1995) Immunolocalization of TGF-β1 in human hypertrophic scar and normal dermal tissues. Cytokine 7: 184-90.
37. Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB. (1983) Transforming growth factor beta in human platelets. J Biol Chem 258: 7155-60.
38. Van Obberghen-Schilling, Roche NS, Flanders KC, Sporn MB, Roberts AB. (1988) Transforming growth factor β1 positively regulates its own expression in normal and transformed cells. J Biol Chem 263: 7741-6.
39. Bassols A, Massague J. (1988) Transforming growth factor β regulates the expression and structure of extracellular matrix chondroitin/dermatan sulfate proteoglycans. J Biol Chem 263: 3039-45.
40. Westergren-Thorsson G, Antonsson P, Malmstrom A, Heinegard D, Oldberg A. (1991) The synthesis of a family of structurally related proteoglycans in fibroblasts is differently regulated by TGF-β. Matrix 11: 177-83.
41. Santra M, Danielson KG, Iozzo RV. (1994) Structural and functional characterization of the human decorin gene promoter. J Biol Chem 269: 579-87.
42. Yeo TK, Brown L, Dvorak HF. (1991) Alterations in proteoglycan synthesis common to healing wounds and tumors. Am J Pathol 138: 1437-50.
43. Scott JE. (1993) Proteoglycan-fibrillar collagen interactions in tissues: dermatan sulphate proteoglycan as a tissue organizer. In: Scott JE, ed. Dermatan sulphate proteoglycans: chemistry, biology, chemical pathology. London: Portland Press, pp. 165-81.
44. Yamaguchi Y, Mann DM, Ruoslahti E. (1990) Negative regulation of transforming growth factor-β by the proteoglycan decorin. Nature (London) 346: 282-4.
45. Border WA, Noble NA, Yamamoto T, et al. (1992) Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease. Nature (London) 340: 361-4.
46. Isaka Y, Brees DK, Ikegaya K, et al. (1996) Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nature Med 2: 418-23.