Functional and morphologic evidence of the presence of tissue- plasminogen activator in vascular nerves: Implications for a neurologic control of vessel wall fibrinolysis and rigidity

Journal of Neuroscience Research

Volumn 53, Issue 4, 1998, Pages 443-453

  Wang, Yafei ^a   Hand, Arthur R ^a   Wang, Yu Hsiung ^a   Mina, Mina ^a   Gillies, Concettina ^a   Peng, Tao ^a   Cone, Robert E ^a   O'Rourke, James ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Plasminogen activator; Vascular nerve tissue

Indexed keywords

MATRIX METALLOPROTEINASE; MESSENGER RNA; PLASMIN; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INNERVATION; BLOOD VESSEL WALL; CAROTID ARTERY; CHOROID VASCULARIZATION; CONTROLLED STUDY; EXPLANT; FEMALE; FIBRINOLYSIS; HYPERTENSION; IN SITU HYBRIDIZATION; IRIS BLOOD VESSEL; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESISTANCE BLOOD VESSEL; STROKE; SUPERIOR CERVICAL GANGLION;

AGING; ANIMALS; ARTERIOLES; AXONS; CAROTID ARTERIES; FEMALE; MUSCLE, SMOOTH, VASCULAR; NEURONS; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RETINAL VESSELS; SUPERIOR CERVICAL GANGLION; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0031902235     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19980815)53:4<443::AID-JNR6>3.0.CO;2-6     Document Type: Article

References (47)

1. Alexander CCM, Werb Z (1991): Extracellular matrix degradation. In Hay ED (ed): "Cell Biology of Extracellular Matrix." New York: Plenum Press, pp 255-302.
2. Alvarez-Buylla A, Valinsky JE (1985): Production of plasminogen activator in cultures of superior cervical ganglia and isolated Schwann cells. Neurobiology 82:3519-3523.
3. Bashkov GB, Sergeev II, Medvedeva N (1993): Role of the sympathetic cholinergic pathway in the neurogenic control of the release of tissue-type plasminogen activator into the blood. Blood Coagul Fibrinolysis 4:993-998.
4. Bevan JA, Bevan RD, Duckles S (1980): Adrenergic regulations of vascular smooth muscle. In Bohr DF, Somlyo AR, and Sparks HU (eds): "Handbook of Physiology." Vol. II. Section 2. Washington, DC: American Physiology Society, pp 515-566.
5. Burnstock G, Costa M (1975): Structure of adrenergic neurons and related cells. In "Adrenergic Neurons: Their Organization. Function and Development in the Peripheral Nervous System." London: Chapman and Hall, pp 19-37, plate 10.
6. Burnstock G, Cannon B, Iwayama T (1970): Sympathetic innervation of vascular smooth muscle in normal and hypertensive animals. Circ Res Suppl 27:II-5-II-22.
7. Burnstock G, Griffith SD, Sneddon P (1984): Autonomie nerves in the precapillary vessel wall. J Cardiovasc Pharmacol Suppl 6:344-351.
8. Cash JD (1975): Neurohumoral pathways associated with the release of plasminogen activator in man. In Davidson JF, Samama MM, Desnoyers PC (eds): "Progress in Chemical Fibrinolysis and Thrombolysis." Vol. 1. New York: Raven Press, pp 97-107.
9. Coccheri S, Astrup T (1961): Thromboplastic and fibrinolytic activities of large human vessels. Proc Soc Exp Biol Med 108:369-372.
10. Connolly ES, Huang J, Goldman JE, Hoetzman RNN (1996): Immunohistochemical detection of intramural vasa vasorum: A human autopsy study. Neurosurgery 39:789-793.
11. Dail WG, Barton S (1983): Structure and organization of mammalian sympathetic ganglia. In Elfin L-G (ed): "Autonomie Ganglia." New York: John Wiley & Sons, pp 3-25.
12. Emeis JJ (1988): Mechanisms involved in short-term changes in blood levels of t-PA. In Kluff C (ed): "Tissue Plasminogen Activator: Physiological and Clinical Aspects." Vol. II. Boca Raton: CRC Press, pp 22-35.
13. Emeis JJ, van den Ennden-Schrauwen, Kooistra T (1996): Tissue-type plasminogen activator and the vessel wall: Synthesis, storage and secretion. In van Hinsbergh VWM (ed): "Vascular Control of Haemostasis." Newark, NJ: Gordon and Breach, pp 187-206.
14. Emeis JJ, Verheijen JH, Ronday HK, deMaat MPM, Brakman P (1997): Progress in clinical fibrinolysis. Fibrinolysis Proteolysis 11: 67-84.
15. Gualandris A, Jones TE, Strickland S, Tsirka SE (1996): Membrane depolarization induces calcium-dependent secretion of tissue plasminogen activator. J Neurosci 16:2220-2225.
16. Hand AR (1995): Electron microscopy. In Glasel JA, Deutscher M (eds): "Introduction to Biophysical Methods for Protein and Nucleic Acid Research." New York: Academic Press, pp 205-260.
17. Hegt VN (1977): Relations between activation and inhibition of fibrinolysis in the walls of human arteries and veins. Thromb Haemost 38:407-419.
18. Hendry IA, Stockel K, Thoenen H, Iversen LL (1974): The retrograde axonal transport of nerve growth factor. Brain Res 68:102-121.
19. Kannel WB, Wolf PA, McGee DL, Dawber TR, McNamara P, Castelli WP (1981): Systolic blood pressure, arterial rigidity and stroke: The Framingham Study. JAMA 245:125-129.
20. Kelley RP, Gallahger DE, Lee LL, O'Rourke MF (1996): Arterial stiffness and vascular/ventricular interaction in humans. In Loscazlo J, Creager MA, Dzau VJ (eds): "Vascular Medicine: A Text Book of Vascular Biology and Medicine." 2nd ed. Boston: Little Brown and Co., pp 185-206.
21. Larsson A, Astedt B (1985): Immunohistochemical localization of tissue plasminogen activator and urokinase in the vessel wall. J Clin Patnol 38:140-145.
22. Levin G, del Zoppo GJ (1994): Localization of tissue plasminogen activator in the endothelium of a limited number of vessels. Am J Pathol 144:855-861.
23. Li H, Grimes P (1993): Adrenergic innervation of the choroid and iris in diabetic rats. Curr Eye Res 12:89-94.
24. Ljungner H, Holmbert L, Kjeldgaard A, Nilsson IM, Astedt B (1983): Immunological characterization of plasminogen activators in the human vessel wall. J Clin Pathol 36:1046-1049.
25. McFarlane RG, Biggs R (1946): Fibrinolysis: Its mechanism and significance. Blood 3:1167-1187.
26. Mina M, Kollar EV, Upholt WB (1991): Temporal and spatial expression of genes for cartilage extracellular matrix proteins during avian mandibular arch development. Differentiation 48:17-24.
27. Mizutani A, Tanaka T, Saito H, Matsuki N (1997): Postsynaptic blockade of inhibitory postsynaptic currents by plasmin in CAI pyramidal cells of rat hippocampus. Brain Res 761:93-96.
28. Murphy HC, Hand AR, Dowd FJ (1994): Localization of an ecto-ATPase cell-CAM 105 (C-CAM) in the rat parotid and submandibular glands. J Histochem Cytochem 425:561-568.
29. Owman CH, Sjoberg N-O, Sweden G (1971): Histochemical and chemical studies on pre and post-natal development of the different systems of short and long adrenergic neurons in peripheral organs of the rat. Z Zell Forsch Mikrosk Anat 116:319-341.
30. Parmer RJ, Mahata M, Mahata S, Sebald MT, O'Connor DT, Wiles LA (1997): Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway. J Biol Chem 272:1976-1982.
31. Phillips GD, Stone AM, Schultz JC, Whitehead RA, Jones BD, Goodkin ML, Reubel MW, Knighton DR (1995): Age-related alterations in the morphology of femoral artery vasa vasorum in the rat. J Mech Age Dev 82:149-154.
32. Pittman RN (1985): Release of plasminogen activator and a calcium-dependent metalloprotease from cultured sympathetic and sensory neurons. Dev Biol 110:91-101.
33. Pittman RN, Buettner HM (1982): Degradation of the extracellular matrix by neuronal proteases. Dev Neurosci 11:361-375.
34. Pittman RN, Ivins JK, Buettner HM (1989): Neuronal plasminogen activators: Cell surface binding sites and involvement in neurite outgrowth. J Neurosci 9:4269-4286.
35. Prowse CV, MacGregor IR (1988): Regulation of the plasminogen activation in blood. In Kluft C (ed): "Tissue-type Plasminogen Activator (t-PA). Physiological and Clinical Aspects." Vol. II. Boca Raton: CRC Press, pp 49-66.
36. Rijken DD, Wijngaards G, Welbergen J (1980): Relationship between tissue plasminogen activator and the activators in blood and vascular wall. Thromb Res 18:815-830.
37. Saksela O, Rifkin DB (1988): Cell-associated plasminogen activation: Regulation and physiological functions. Ann Rev Cell Biol 4:93-126.
38. Seyer JM, Kang AH (1996): Connective tissues of the subendothelium. In Loscazlo J, Crager MA, Dzau VJ (eds): "Vascular Medicine: A Text Book of Vascular Biology and Disease." 2nd ed. Boston: Little Brown and Co., pp 39-67.
39. Sheenan DC, Hrapchak BB (1980): Bodian's method. In "Theory and Practice of Histofechnology." St. Louis: CV Mosby, pp 256-258.
40. Sherry S, Lindenmeyer R, Fletcher AP, Alkjaersig N (1959): Studies on enhanced tibrinolytic activity in man. J Clin Invest 38:810-822.
41. Smokovitis A, Astrup A (1983): Plasminogen activator activity and plasmin inhibition in nerves. Haemostasis 13:136-144.
42. Stone RA, Laites AM, Emson PC (1986): Neuropeptide Y and the ocular innervation of rat, guinea pig, cat and monkey. Neuroscience 17:1207-1216.
43. Todd AS (1959): The histological localization of fibrinolysis activator. J Pathol Bacteriol 78:281-283.
44. Wang Y, Taylor DM, Smalley DM, Cone RE, O'Rourke J (1994): Increased basal levels of free plasminogen activator activity found in human aqueous humor. Invest Ophthalmol Vis Sci 35:3561-3566.
45. Wang Y, Gillies CG, Cone RE, O'Rourke J (1995): Extravascular secretion of t-PA by the intact superfused choroid. Invest Ophthalmol Vis Sci 36:1625-1632.
46. Wang Y, Hand AR, Gillies C, Grunnet ML, Cone RE, O'Rourke J (1997a): Morphologic evidence tor a preferential storage of tissue plasminogen activator (t-PA) in perivascular axons of the rat uvea. Exp Eye Res 65:105-116.
47. Wang Y, Hand AR, Cone RE, Gillies C, Grunnet ML, O'Rourke J (1997b): Ultrastructural and pharmacologic evidence for t-PA storage in perivascular nerve endings. Microcirc 4:163. (Abst. 254, Vascular Biology '97, New Orleans).