Multiple cocaine-induced seizures and corresponding cocaine and metabolite concentrations

American Journal of Emergency Medicine

Volumn 16, Issue 5, 1998, Pages 529-533

  Winbery, Stephen ^a   Blaho, Kari ^a   Logan, Barry ^c   Geraci, Stephen ^b  

^a UT Medical Group   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Benzoylecgonine; Cocaine; Crack; Ecgonine; Ingestions; Norcocaine; Seizures

Indexed keywords

COCAINE; LABETALOL; LORAZEPAM;

ADULT; ARTICLE; CASE REPORT; DRUG ABUSE; DRUG BLOOD LEVEL; DRUG METABOLISM; HUMAN; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; SEIZURE; SUBSTANCE ABUSE; TACHYCARDIA; TONIC CLONIC SEIZURE;

EID: 0031902188     PISSN: 07356757     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-6757(98)90012-2     Document Type: Article

References (31)

1. Alldredge BK, Lowenstein DH, Simon RP: Seizures associated with recreational drug abuse. Neurology 1989;39:1037-1039
2. Pascual-Leone A, Dhuana A, Altafulla I, Anderson DC: Cocaine-induced seizures. Neurology 1990;40:404-407
3. Bradberry CW, Nobiletti JB, Elsworth JD, et al: Cocaine and cocaethylene: Microdialysis comparison of brain drug levels and effects on dopamine and serotonin. J Neurochem 1993;60:1429-1435
4. van Rossum JM: Mode of action of psychomotor stimulants, Int Rev Neurobiol 1970;12:307-383
5. Pettit HO, Pan H, Parsons LH, Justice JB Jr: Extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration. J Neurochem 1990;55:798-804
6. Ritchie JM, Green NM: Local anesthetics. In Gilman AG, Goodman LS, Rail TW, Murad F (eds): The Pharmacological Basis of Therapeutics (ed 7). New York, NY, Macmillan, 1990, pp 309-310
7. Qian XB, Andy OJ, Dearman C, et al: Cocaine-induced brainstem seizures and behavior, Integ Physiol Behav Sci 1992;27:117-129
8. Ritz MC, George FR: Cocaine-induced seizures and lethality appear to be associated with distinct central nervous system binding sites. J Pharmacol Exp Ther 1993;264:1333-1343
9. Schechter MD, Meehan SM: Serotonergic mediation of cocaine seizures in mice. Pharmacol Biochem Behav 1995;51:313-316
10. Choy-Kwong M, Lipton RB: Seizures in hospitalized cocaine users. Neurology 1989;39:425-427
11. Casas PI, Gatto E, Fernandez PMM, et al: Neurologic complications by cocaine abuse. Medicina 1994;54:35-41
12. Jonsson S, O'Mera M, Young JB: Acute cocaine poisoning: Importance of treating seizures and acidosis. Am J Med 1983;75:1061-1064
13. Smirnow D, Logan BK: Analysis of cocaine and other cocaine biotransformation products in postmortem whole blood by protein precipitation/extractive alkalation and GCMS. J Anal Toxicol 1996;20: 463-467
14. Olson KR, Kearney TE, Dyer JE, et al: Seizures associated with poisoning and drug overdose. Am J Emerg Med 1994;12:392-395
15. Schwartz RH: Seizures associated with smoking "crack" - A survey of adolescent "crack" smokers. West J Med 1989;150:215
16. Kramer LD, Locke GE, Ogunyemi A, Nelson L: Cocaine-related seizures in adults. Am J Drug Alcohol Abuse 1990;16:307-317
17. Myers JA, Earnest MP: Generalized seizures and cocaine abuse. Neurology 1984;34:675-676
18. Lowenstein DH, Bassa SM, Rowbotham MC, et al: Acute neurologic and psychiatric complications associated with cocaine abuse. Am J Med 1987;83:841-846
19. Riggs D, Weibley RE: Acute toxicity from oral ingestion of crack cocaine: A report of four cases. Ped Emerg Care 1990;6:24-26
20. Holland RW 3rd, Marx JA, Earnest MP, Ranniger S: Grand mal seizures temporally related to cocaine use: Clinical and diagnostic features. Ann Emerg Med 1992;21:772-776
21. Drug Facts and Comparisons. St. Louis, MO, J.B. Lippincott, 1996, p 261 g
22. Van Dyke C, Barash PG, Jatlow P, Byck R: Cocaine: Plasma concentrations after intranasal application in man. Science 1976;191: 859-861
23. Hamilton HE, Wallace JF, Shimek EL Jr, et al: Cocaine and benzoylecgonine excretion in humans. J Forensic Sci 1977;22:697-707
24. Smart RG, Anglin L: Do we know the lethal dose of cocaine? J Forensic Sci 1987;32:303-312
25. Wetli CV, Wright RK: Death caused by recreational cocaine use. JAMA 1979;241:2519-2522
26. Logan BK, Smirnow D, Gullberg RG: Lack of predictable site-dependent differences and time-dependent changes in postmortem concentrations of cocaine, benzoylecgonine, and cocaethylene in humans. J Anal Toxicol 1997;20:23-31
27. Lora-Tamayo C, Tena T, Rodriguez A: Cocaine-related deaths. J Chromatography A 1994;674:217-224
28. Caughlin LJ, O'Halloran RL: Case report. An accidental death related to cocaine, cocaethylene and caffeine. J Forens Sci 1993;38: 1513-1515
29. Amon CA, Tate LG, Wright RK, Matusiak W: Sudden death due to ingestion of cocaine. J Anal Toxicol 1986;10:217-218
30. Brookoff D, Rotondo MF, Shaw LM, et al: Cocaethylene levels in patients who test positive for cocaine. Ann Emerg Med 1995;27:316-320
31. Wilkinson P, Van Dyke C, Jatlow P, et al: Intranasal and oral cocaine kinetics. Clin Pharm Ther 1980;27:386-394