Role of antigen-induced cytokine release in atopic pruritus

International Archives of Allergy and Immunology

Volumn 116, Issue 1, 1998, Pages 36-39

  Lippert, U ^a   Hoer, A ^b   Moller A ^a   Ramboer, I ^c   Cremer, B ^a   Henz, B M ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UCB PHARMA   (Belgium)

Author keywords

Antihistamines; Atopic eczema; Cytokines; Pruritus

Indexed keywords

CETIRIZINE; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HOUSE DUST ALLERGEN; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; POLLEN ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; ATOPIC DERMATITIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; CYTOKINE RELEASE; DOUBLE BLIND PROCEDURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MALE; PRICK TEST; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; ALLERGENS; ANIMALS; ANTI-ALLERGIC AGENTS; ANTIGENS; CETIRIZINE; CROSS-OVER STUDIES; CULTURE MEDIA, CONDITIONED; CYTOKINES; DERMATITIS, ATOPIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INTERLEUKIN-2; INTERLEUKIN-8; MALE; MIDDLE AGED; MITES; POLLEN; PRURITUS; SEVERITY OF ILLNESS INDEX; SKIN DISEASES; SKIN TESTS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031900010     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000023922     Document Type: Article

References (13)

1. Berth-Jones J, Graham-Brown RAC: Failure of terfenadine in relieving the pruritus of atopic dermatitis. Br J Dermatol 1989;121:635-637.
2. Wallengren J: The pathophysiology of itch. Clin Rep 1993;3:643-647.
3. Asnis LA, Gaspari AA: Cutaneous reactions to recombinant cytokine therapy. Dermatology 1995;33:393-410.
4. Wahlgren CF: Pathophysiology of itching in urticaria and atopic dermatitis. Allergy 1992;47: 65-75.
5. Wahlgren CF, Rengvall Linder M, Hägermark Ö, Scheynius A: Itch and inflammation induced by intradermally injected interleukin-2 in atopic dermatitis patients and healthy subjects. Arch Dermatol Res 1995;287:572-580.
6. Cremer B, Heimann A, Dippel E, Czarnetzki BM: Pruritogenic effects of mitogen-stimulated peripheral blood mononuclear cells in atopic eczema. Acta Derm Venereol (Stockh) 1995; 75:426-428.
7. Hanifin JM, Rajka G: Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 1980;92:44-47.
8. Fadel R, Herpin-Richard N, Dufresne F, Rihoux JP: Pharmacological modulation by cetirizine and loratadine of antigen and histamine-induced wheals and flare, and late accumulation of cosinophils. J Int Med Res 1990;18:366-371.
9. Krüger-Krasagakes S, Möller A, Kolde G, Lippert U, Weber S, Henz BM: Production of interleukin-6 by human mast cells and basophilic cells. J Invest Dermatol 1996;106:75-79.
10. Flick DA, Gifford GE: Comparison of in vitro cell cytotoxic assays for tumor necrosis factor. J Immunol Methods 1984;68:167-175.
11. Heyer G, Hornstein OP, Handwerker HO: Skin reactions and itch sensation induced by epicutaneous histamine application in atopic dermatitis and control. J Invest Dermatol 1989;93:492-496.
12. Heyer G, Homstein OP, Handwerker HO: Reactions of intradermally injected substance P and topically applied mustard oil in atopic dermatitis patients. Acta Derm Venereol (Stockh) 1991;71:291-295.
13. McHugh SM, Wilson AB, Deighton J, Lachmann PJ, Ewan PW: The profiles of interleukin (IL)-2, IL-6, and interferon-gamma production by peripheral blood mononuclear cells from house-dust-mite-allergic patients: A role for IL-6 in allergic disease. Allergy 1994;49:751-759.