High prevalence of thrombocytopenia in SLE patients with a high level of anticardiolipin antibodies combined with lupus anticoagulant

American Journal of Hematology

Volumn 58, Issue 1, 1998, Pages 55-60

  Nojima, Junzo ^a   Suehisa, Etsuji ^a   Kuratsune, Hirohiko ^b   Machii, Takashi ^b   Toku, Masayuki ^a   Tada, Hisato ^a   Yamaguti, Kouzi ^b   Koike, Takao ^c   Kanakura, Yuzuru ^b   Kitani, Teruo ^d   Amino, Nobuyuki ^b  

^a OSAKA UNIVERSITY HOSPITAL   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d SAKAI MUNICIPAL HOSPITAL   (Japan)

Author keywords

Anticardiolipin antibodies; Lupus anticoagulant; Systemic lupus erythematosus; Thrombocytopenia; Thrombosis

Indexed keywords

CARDIOLIPIN ANTIBODY; LUPUS ANTICOAGULANT;

ADOLESCENT; ADULT; AGED; ANTIBODY DETECTION; ARTICLE; DISEASE ASSOCIATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOSIS;

ADOLESCENT; ADULT; AGED; ANTIBODIES, ANTICARDIOLIPIN; ARTERIES; FEMALE; HUMANS; INCIDENCE; LUPUS COAGULATION INHIBITOR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; PREVALENCE; REFERENCE VALUES; THROMBOCYTOPENIA; THROMBOPHLEBITIS; THROMBOSIS;

EID: 0031899652     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8652(199805)58:1<55::AID-AJH10>3.0.CO;2-4     Document Type: Article

References (24)

1. Gladman DD, Urowitz MB, Tozman EC, Glynn MFX: Haemostatic abnormalities in systemic lupus erythematosus. Q J Med, New Series LII 207:424-433, 1983.
2. Harris EN, Gharavi AE, Boey ML, Patel BM, Mackworth-Young CG, Loizou S, Hughes GRV: Anticardiolipin antibodies: Detection by radioimmuno assay and association with thrombosis in systemic lupus erythematosus. Lancet 2:1211-1214, 1983.
3. Hughes GRV, Harris EN, Gharavi AE: The anticardiolipin syndrome. J Rheumatol 13:486-489, 1986.
4. Boey ML, Colaco CB, Gharavi AE, Elkon KB, Loizou S, Hughes GRV: Thrombosis in systemic lupus erythematosus: Striking association with the presence of circulating lupus anticoagulant. Br Med J 287:1021-1023, 1983.
5. Koike T, Sueishi M, Funaki H, Tomioka H, Yoshida S: Anticardiolipin antibodies and biological false positive serological test for syphilis in patients with systemic lupus erythematoses. Clin Exp Immunol 56: 193-199, 1984.
6. Harris EN, Asherson RA, Gharavi AE, Morgan SH, Derue G, Hughes GRV: Thrombocytopenia in SLE and related autoimmune disorders: Association with anticardiolipin antibody. Br J Haematol 59:227-230, 1985.
7. Harris EN, Chan JKH, Asherson RA, Aber VR, Gharavi AE, Hughes GRV: Thrombosis, recurrent fetal loss, and thrombocytopenia. Arch Intern Med 146:2153-2156, 1986.
8. Gharavi AE, Harris EN, Asherson RA, Hughes GRV: Anticardiolipin antibodies: Isotype distribution and phospholipid specificity. Ann Rheum Dis 46:1-6, 1987.
9. Lechner K: Lupus anticoagulants and thrombosis. International Society on Thrombosis and Leuven University Press 525-547, 1987.
10. Galli M, Comfurius P, Maassen C, Hemker HC, De Baets MH, van Breda-Vriesman PJC, Barbui T, Zwaal RFA, Bevers EM: Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 335:1544-1547, 1990.
11. McNeil HP, Chesterman CN, Krilis SA: Immunology and clinical importance of antiphospholipid antibodies. Adv Immunol 49:193-280, 1991.
12. Italian Registry of Antiphospholipid Antibodies (IR-APA): Thrombosis and thrombocytopenia in antiphospholipid syndrome (idiopathic and secondary to SLE): First report from the Italian Registry. Haematologica 78:313-318, 1993.
13. Nojima J, Suehisa E, Akita N, Toku M, Fushimi R, Tada H, Kuratsune H, Machii T, Kitani T, Amino N: Risk of arterial thrombosis in patients with anticardiolipin antibodies and lupus anticoagulant. Br J Haematol 96:447-450, 1997.
14. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA: Antiphospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation; b2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci USA 87:4120-4124, 1990.
15. Koike T, Matsuura E: What is the "true" antigen for anticardiolipin antibodies? Lancet 337:671, 1991.
16. Bevers EM, Galli M: b2-glycoprotein I for binding of anticardiolipin antibodies to cardiolipin. Lancet ii:952-953, 1990.
17. Keeling DM, Wilson ALG, Mackie IJ, Machin SJ, Isenberg DA: Some antiphospholipid antibodies bind to b2-glycoprotein I in the absence of phospholipid. Br J Haematol 82:571-574, 1992.
18. Matsuura E, Igarashi Y, Yasuda T, Koike T, Triplett DA: Anticardiolipin antibodies recognize b2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J Exp Med 179: 457-462, 1994.
19. Matsuura E, Igarashi Y, Fujimoto M, Ichikawa K, Suzuki T, Sumida T, Yasuda T, Koike T: Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. J Immunol 148:3885-3891, 1992.
20. Schleider MA, Nachman RL, Jaffe EA, Coleman M: A clinical study of the lupus anticoagulant. Blood 48:499-509, 1976.
21. Triplett DA, Barna LK, Unger GA: A hexagonol (II) phase phospholipid neutralization assay for lupus anticoagulant identification. Thromb Haemost 70:787-793, 1993.
22. Tsubakio T, Kurata Y, Yonezawa T, Kitani T: Quantification of platelets associated IgG with competitive solid-phase enzyme immunoassay. Acta Haematol 66:251-256, 1981.
23. Stasi R, Stipa E, Oliva F, Sciarra A, Perrotti A, Olivieri M, Zaccari G, Gandolfo MG, Galli M, Barbui T, Papa G: Prevalence and clinical significance of elevated antiphospholipid antibodies in patients with idiopathic thrombocytopenia purpura. Blood 84:4203-4207, 1994.
24. Galli M: Thrombocytopenia in the antiphospholipid syndrome. Br J Haematol 93:1-5, 1996.