Tissue distribution and metabolism of radioiodinated DTPA0, D-Tyr1 and Tyr3 derivatives of octreotide in rats

Anticancer Research

Volumn 18, Issue 1 A, 1998, Pages 83-89

  Breeman, Wout A P ^a   De Jong, Marion ^b   Bernard, Bert ^b   Hofland, Leo J ^b   Srinivasan, Ananth ^b   Van Der Pluijm, Marcel ^b   Bakker, Willem H ^b   Visser, Theo J ^b   Krenning, Eric P ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

Chelators; DTPA; Octreotide; Radioiodine; Receptor scintigraphy; Somatostatin analogs

Indexed keywords

OCTREOTIDE; PENTETIC ACID; SOMATOSTATIN RECEPTOR;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG TISSUE LEVEL; DRUG UPTAKE; HYPOPHYSIS TUMOR; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; RADIOIODINATION; RAT; TISSUE DISTRIBUTION; URINARY EXCRETION;

ANIMALS; BINDING, COMPETITIVE; CELL MEMBRANE; IODINE RADIOISOTOPES; MALE; MICE; OCTREOTIDE; PENTETIC ACID; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 0031899520     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Krenning EP, Bakker WH, Breeman WAP, Koper JW, Kooij PPM, Ausema L, Lameris JS, Lamberts SWJ: Localization of endocrine related tumours with radioiodinated analogue of somatostatin. Lancet 1: 242-245, 1989.
2. Bakker WH, Krenning EP, Breeman WAP, Koper JW, Kooij PPM, Reubi J-C, Klijn JG, Visser TJ, Docter R, Lamberts SWJ: Receptor scintigraphy with a radioiodinated somatostatin analogue: radiolabeling, purification, biologic activity, and in vivo application in animals. J Nucl Med 31: 1501-1509, 1990.
3. 1]octreotide, a potential radiopharmaceutical for imaging of somatostatin receptor-positive tumors: Synthesis radiolabeling and in vitro validation. Life Sci 49: 1583-1591, 1991.
4. 3]-octreotide: the Rotterdam experience with more than 1000 patients. Eur J Nucl Med 20: 716-731, 1993.
5. Duncan JR, Stephenson MT, Wu HP, Anderson CJ. Indium- 111 -Diethyletriaminepentaacetic acid-Octreotide is delivered in vivo to pancreatic, tumor cell, renal and hepatocyte Iysosomes: Cancer Res 57: 659-671, 1997.
6. 1]-octreotide. A case history. Ann New York Acad Sci 733: 496-506, 1994.
7. 1]octreotide. Eur J Nucl Med 21: 328-335, 1994.
8. 3]octreotide. Eur J Nucl Med 20: 1089-1094, 1993.
9. Schmidt MA, Wilhelm RR, Srinivasan A. Synthesis of peptide alcohols using Rink acid resin. American Peptide Symposium, Nashville, Tennessee, P159, 1997.
10. Srinivasan A, Schmidt MA. Tri-t-butyl-DTPA: a versatile synthon for the synthesis of DTPA containing peptides. American Peptide Symposium, Nashville, Tennessee, P110, 1997.
11. Hofland LJ, van Koetsveld PM, Verleun TM, Lamberts SWJ: Long-term culture of mammatrope and somatrope subpopulations separated on continous Percoll density gradients: Effect of dopamine, TRH, GHRH, and somatostatin. Acta Endocrinol 122: 127-136, 1990.
12. 3]octreotide by mouse and human pituitary tumor cells: increase by unlabeled octreotide. Endocrinology 136: 3698-3706, 1995.
13. Breeman WAP, Kwekkeboom DJ, Kooij PPM, Bakker WH, Hofland LJ, Visser TJ, Ensing GJ, Lamberts SWJ, Krenning EP: Effect of dose and specific activity on tissue distribution of indium-111-pentetreotide in rats. J Nucl Med 36: 623-627, 1995.
14. th edition. Ames, IA-Iowa State University Press; 1980, pp 233-236.
15. Reubi JC: New specific radioligand for one subpopulation of brain somatostatin receptors. Life Sci 36: 1829-1836, 1985.
16. Behr TM, Sharkey RM, Blumenthal RD, Sgouros G, Dunn RM, Alisauskus R, Griffiths G, Goldenberg DM: Overcoming nefrotoxicity in therapy with radiometal- conjugated antibody fragments and peptides: improvement of their therapeutic efficacy? J Nucl Med 37: 96P(ab), 1996.
17. 3]octreotide uptake. J Nucl Med 38: in press, 1997.
18. De Jong M, Rolleman EJ, Bernard BF, Visser TJ, Bakker WH, Breeman WAP, Krenning EP: Inhibition of renal uptake of Indium-111-DTPA-octreotide in vivo, J Nucl Med 37: 1388-1392, 1996.